Herbicidal sulfonamides

ABSTRACT

The invention relates to sulfonylurea compounds with a substituted or unsubstituted bicyclic nine-membered ring having one to five heteroatoms which are preemergent and/or postemergent herbicides or plant growth regulants.

RELATED APPLICATION

This application is a continuation-in-part of application U.S. Ser. No. 080,471 filed July 31, 1987, now abandoned.

BACKGROUND OF THE INVENTION

This invention relates to novel sulfonylurea compounds, agriculturally suitable compositions thereof and a method of using them to control the growth of undesired vegetation.

New compounds effective for controlling the growth of undesired vegetation are in constant demand. In the most common situation, such compounds are sought to selectively control the growth of weeds in useful crops such as cotton, rice, corn, wheat and soybeans, to name a few. Unchecked weed growth in such crops can cause significant losses, reducing profit to the farmer and increasing costs to the consumer. In other situations, herbicides are desired which will control all plant growth. Examples of areas in which complete control of all vegetation is desired are areas around railroad tracks, and industrial storage areas. There are many products commercially available for these purposes, but the search continues for products which are more effective, less costly and environmentally safe.

The "sulfonylurea" herbicides are an extremely potent class of herbicides discovered within the last few years. A multitude of structural variations exist within this class of herbicides, but they generally consist of a sulfonylurea bridge, --SO₂ NHCONH--,

U.S. No. 4,369,320 and U.S. No. 4,453,970 disclose herbicidal quinolinylsulfonylureas.

U.S. No. 4,391,627 discloses herbicidal benzothiophenesulfonylureas.

EP-A-70,698 published 1/26/83 discloses herbicidal indolesulfonylureas.

EP-A-146,263, published 6/26/85 discloses herbicidal sulfonylureas of the formula ##STR1## wherein J is ##STR2## E is a bridge of 3 or 4 atoms, which may be substituted or unsubstituted, containing 0 to 2 heteroatoms selected from the group consisting of oxygen, sulfur and nitrogen and also containing 1-4 atoms of carbon, said bridge together with two carbon attachment sites forming a partially saturated 5- to 6-membered carbocyclic or heterocyclic ring; or E is a bridge of 3 or 4 atoms which may be substituted or unsubstituted containing at least 1 heteroatom selected from 0-1 oxygen or sulfur or 0-2 nitrogen and 1-3 atoms of carbon, said bridge together with two carbon attachment sites forming an unsaturated 5- to 6-membered heterocyclic ring, with the proviso that when E contains two atoms of oxygen or sulfur, then they must be separated by at least one atom of carbon and that oxygen and sulfur are only linked to each other if the sulfur is in the form of SO or SO₂ ; in the bridging group E, nitrogen may take the form of N or N--O, sulfur may take the form of S, SO or SO₂, and one of the atoms of carbon may be a carbonyl, thiocarbonyl or the cyclic 5- and 6-membered ketals thereof; and

G is O, S, NH or NCH₃.

U.S. No. 4,622,062 disclosed herbicidal sulfonylureas of the formula ##STR3## wherein L, in part, is ##STR4## Q₁ is O, S or SO₂.

U.S. No. 4,643,759 discloses herbicidal compounds of the formula ##STR5## wherein Q is ##STR6## W is O, S or NR₃

U.S. No. 4,678,499 discloses herbicidal compounds of the formula ##STR7## wherein Q is ##STR8## G is CH₂, CH₂ CH₂, O, S, NH, NCH₃ or CH═CH; G₁ is CH₂, CH₂ CH₂ or CH═CH;

J, in part, is CH₂, C(O), S(O)_(m), O, NH or NCH₃ ;

n and n₁ are independently 0 or 1; and

E is a bridge of 3 or 4 atoms containing 0-2 heteroatoms selected from the group consisting of oxygen, sulfur and nitrogen, wherein 1 atom of sulfur may take the form of SO or SO₂, said bridge also containing 1 to 4 atoms of carbon wherein 1 atom of carbon may take the form of C═O, said bridge together with two attachment sites forming a non-aromatic heterocyclic or carbocyclic ring optionally substituted by 1 to 3 substituent groups selected from the group L, or E is a bridge of 3 or 4 atoms containing 0-1 heteroatoms of oxygen or sulfur and 0-3 heteroatoms of nitrogen, said bridge also containing 0-4 atoms of carbon, said bridge together with two attachment sites forming an aromatic heterocyclic or carbocyclic ring optionally substituted by 1 to 3 substituents selected from the group L, with the proviso that when E contains two oxygen atoms or two sulfur atoms said atoms must be separated by at least one atom of carbon and that oxygen and sulfur are only linked to each other if the sulfur is in the form of SO or SO₂ ;

U.S. No. 4,671,817 discloses herbicidal compounds of the formula ##STR9## wherein L is ##STR10##

U.S. No. 4,723,987 discloses herbicidal compounds of the formula ##STR11## wherein J is ##STR12## E is a bridge of 3 or 4 atoms, which may be substituted or unsubstituted, containing 0-2 heteroatoms selected from the group consisting of oxygen, sulfur and nitrogen, and also containing 1-4 atoms of carbon, said bridge together with two carbon attachment sites forming a partially saturated 5- or 6-membered carbocyclic or heterocyclic ring; or E is a bridge of 3 or 4 atoms, which may be substituted or unsubstituted, containing 0-1 heteroatoms selected from oxygen or sulfur, 0-2 heteroatoms of nitrogen and 1-4 atoms of carbon said bridge together with two carbon attachment sites forming a fully unsaturated 5- or 6-membered carbocyclic or heterocyclic ring, with the proviso that when E contains two atoms of oxygen or sulfur, they must be separated by at least one atom of carbon, and the oxygen and sulfur are only linked to each other if the sulfur is in the form of SO or SO₂ ; in the bridging group E, sulfur may take the form of S, SO or SO₂, and one of the atoms of carbon may be a carbonyl, thiocarbonyl or the cyclic 5- and 6-membered ketals thereof.

South African Patent Application 84/8844 and its equivalent U.S. No. 4,605,433, discloses substituted 1,2,4-triazolo-[1,5-a]pyrimidine-sulfonamides of the following formula as herbicides and plant growth regulants. ##STR13##

U.S. No. 4,685,958, discloses substituted 2-amino-1,2,4-triazolo[1,5-A]-1,3,5-triazines of the following formula as herbicides. ##STR14##

EP-A-244,097, published on Nov. 4, 1987, discloses herbicidal pyrazolopyrimidine derivatives of the formula ##STR15## wherein X is --NR--SO₂ --, --SO₂ --O--, --SO₂ --NR-- or --S(O)_(n) CR'R"--.

EP-A-244,098, published on Nov. 4, 1987, discloses herbicidal thiazolotriazolesulfonamides of the formula ##STR16##

U.S. Ser. No. 07/039492 which was allowed discloses herbicidal benzotriazole sulfonylureas.

EP-A-244,166, published Nov. 4, 1987, discloses herbicidal compounds of the formula ##STR17## wherein L, in part, is a benzene, naphthalene, pyrazole, thiophene, pyridine, benzothiophene or an indole moiety;

A, in part is ##STR18## Z is CH, N, CCH₃, CEt, CCl or CBr; Z₁ is C--U, N or N--O;

Z₂ and Z₃ are independently N or C--U;

Z₄ is NCH₃, O, S or CH₂ ; and

U is H, F, Cl, Br, C₁ -C₂ alkyl optionally substituted by F, Cl, Br or OCH₃, CN, NO₂, NMe₂, OR₂₂, or SR₂₂, or CO₂ CH₃.

EP-A-238,070, published Sept. 23, 1987, discloses compounds of the formula ##STR19## wherein Q is a condensed heterocyclic group having N atoms in the bridgehead which may be substituted;

W is O or S;

R₁ and R₂ are independently alkyl, alkoxy or halogen; and

Z is CH or N.

SUMMARY OF THE INVENTION

This invention relates to novel compounds of Formula I, their agriculturally suitable compositions and their method-of-use as preemergent and/or postemergent herbicides or plant growth regulants ##STR20## wherein L is ##STR21## R¹ is H, halogen, C₁ -C₃ alkyl, C₁ -C₃ haloalkyl, OR⁶, SR⁶, S(O)R⁶, S(O)₂ R⁶, CO₂ R⁷, C(O)NR⁸ R⁹, S(O)₂ NR¹⁰ R¹¹, C₂ -C₃ alkenyl, C₂ -C₃ haloalkenyl, C₂ -C₃ alkynyl, NO₂, CN, C(O)R¹², C(R¹³)═NOR¹⁴ or C₁ -C₂ alkyl substituted by C₁ -C₂ alkoxy, C₁ -C₂ alkylthio or CN;

R² is H, C₁ -C₃ alkyl, C₁ -C₃ alkoxy, C₁ -C₂ haloalkoxy or C₁ -C₂ alkyl substituted with OCH₃, SCH₃ or CN;

R³ is H, CH₃ or OCH₃ ;

R⁴ is H or CH₃ ;

R⁵ is H, halogen, C₁ -C₃ alkyl, C₁ -C₃ haloalkyl, OR⁶, SR⁶, S(O)₂ R⁶, CO₂ R⁷, C(O)NR⁸ R⁹, S(O)₂ NR¹⁰ R¹¹, C₂ -C₃ alkenyl, C₂ -C₃ haloalkenyl, C₂ -C₃ alkynyl, NO₂, CN, C(O)R¹², or C₁ -C₂ alkyl substituted by C₁ -C₂ alkoxy, C₁ -C₂ alkylthio or CN;

R⁶ is C₁ -C₃ alkyl, C₁ -C₃ haloalkyl, C₃ alkenyl, C₂ -C₃ haloalkenyl, propargyl, cyclopropyl, cyclopropylmethyl or --CH₂ CH₂ -- substituted by OH, C₁ -C₂ alkoxy, SH, C₁ -C₂ thioalkyl or CN;

R⁷ is C₁ -C₄ alkyl, C₂ -C₃ haloalkyl, allyl, propargyl, cyclopropyl, cyclopropylmethyl, or --CH₂ CH₂ -- substituted by OH, OCH₃, SCH₃ or CN;

R⁸ is H or C₁ -C₂ alkyl;

R⁹ is C₁ -C₃ alkyl, C₁ -C₃ alkoxy, allyl, propargyl, cyclopropyl, CH₂ CN, CH₂ CH₂ CN Or CH₂ CH₂ OCH₃ ;

R¹⁰ is H or C₁ -C₃ alkyl;

R¹¹ is C₁ -C₃ alkyl, C₁ -C₃ alkoxy, allyl, propargyl, cyclopropyl, cyclopropylmethyl, CH₂ CN, CH₂ CN, CH₂ CH₂ CN or CH₂ CH₂ OCH₃ ;

R¹⁰ and R¹¹ can be taken together to form a ring consisting of (--CH₂ --)₄, (--CH₂ --)₅ or (--CH₂ CH₂ --)₂ O;

R¹² is H, C₁ -C₃ alkyl or cyclopropyl;

R¹³ is H, C₁ -C₃ alkyl, cyclopropyl, Cl, CN, OCH₃, SCH₃ or N(CH₃)₂ ;

R¹⁴ is H or C₁ -C₃ alkyl;

Z is N or CH;

Z¹ is N, CH or CCH₃ ;

Z² is O, S or NCH₃ ;

Z³ is O, S or N--R¹⁵ ;

R¹⁵ is H, C₁ -C₂ alkyl, C₁ -C₂ haloalkyl, CH₂ CH₂ OCH₃, CH₂ CH₂ SCH₃, CH₂ CN or CO₂ CH₃ ;

W is O or S;

R is H or CH₃ ;

A is ##STR22## X is H, C₁ -C₄ alkyl, C₁ -C₄ alkoxy, C₁ -C₄ haloalkoxy, C₁ -C₄ haloalkyl, C₁ -C₄ haloalkylthio, C₁ -C₄ alkylthio, halogen, C₂ -C₅ alkoxyalkyl, C₂ -C₅ alkoxyalkoxy, amino, C₁ -C₃ alkylamino or di(C₁ -C₃ alkyl)amino;

Y is H, C₁ -C₄ alkyl, C₁ -C₄ alkoxy, C₁ -C₄ haloalkoxy, C₁ -C₄ haloalkylthio, C₁ -C₄ alkylthio, C₂ -C₅ alkoxyalkyl, C₂ -C₅ alkoxyalkoxy, amino, C₁ -C₃ alkylamino, di(C₁ -C₃ alkyl)amino, C₃ -C₄ alkenyloxy, C₃ -C₄ alkynyloxy, C₂ -C₅ alkyl thioalkyl, C₂ -C₅ alkylsulfinylalkyl, C₂ -C₅ alkylsulfonylalkyl, C₁ -C₄ haloalkyl, C₂ -C₄ alkynyl, C₃ -C₅ cycloalkyl, azido, cyano, ##STR23## or N(OCH₃)CH₃ ; m is 2 or 3;

Q₁ and Q₂ are independently O or S;

R_(a) is H or C₁ -C₃ alkyl;

R_(b) and R_(c) are independently C₁ -C₃ alkyl;

Z⁴ is CH, N, CCH₃, CC₂ H₅, CCl or CBr;

Z⁵ is CH or N;

Y₁ is O or CH₂ ;

X₁ is CH₃, OCH₃, OC₂ H₅ or OCF₂ H;

X₂ is CH₃, C₂ H₅ or CH₂ CF₃ ;

Y₂ is OCH₃, OC₂ H₅, SCH₃, SC₂ H₅, CH₃ or CH₂ CH₃ ;

X₃ is CH₃ or OCH₃ ;

Y₃ is H or CH₃ ;

X₄ is CH₃, OCH₃, OC₂ H₅, CH₂ OCH₃ or Cl;

Y₄ is CH₃, OCH₃, OC₂ H₅ or Cl;

and their agriculturally suitable salts; provided that

(l) when X is halogen, then Z⁴ is CH and Y is OCH₃, OC₂ H₅, NH₂, NHCH₃, N(CH₃)₂, OCF₂ H, OCF₂ Br or N(OCH₃)CH₃ ;

(2) when X or Y is C₁ haloalkoxy, then Z⁴ is CH;

(3) when W is S, then R is H, A is A-1, Z⁴ is CH or N, and Y is CH₃, OCH₃, OC₂ H₅, CH₂ OCH₃, C₂ H₅, CF₃, SCH₃, OCH₂ CH═CH₂, OCH₂ C.tbd.CH, OCH₂ CH₂ OCH₃, CH(OCH₃)₂ or ##STR24## (4) when the total number of carbon atoms of X and Y is greater than four, then the greatest combined number of carbons of any two substituents on an L, selected from R¹, R², R³, R⁴, R⁵ and R¹⁵ is less than or equal to six;

(5) X₄ and Y₄ are not simultaneously Cl;

(6) the total number of carbon atoms of R¹⁰ and R¹¹ is less than or equal to five.

In the above definitions, the term "alkyl", used either alone or in compound words such as "alkylthio" or "haloalkyl", denotes straight chain or branched alkyl, e.g. methyl, ethyl, n-propyl, isopropyl or the different butyl isomers.

Alkoxy denotes methoxy, ethoxy, n-propyloxy, isopropyloxy and the different butyloxy isomers.

Alkenyl denotes straight chain or branched alkenes, e.g. 1-propenyl, 2-propenyl, 3-propenyl and the different butenyl isomers.

Alkynyl denotes straight chain or branched alkynes, e.g. ethynyl, 1-propynyl, 2-propynyl and the different butynyl isomers.

Alkylsulfonyl denotes methylsulfonyl, ethylsulfonyl and the different propylsulfonyl isomers.

Alkylthio, alkylsulfinyl, alkylamino, etc. are defined analogously to the above examples.

Cycloalkyl denotes cyclopropyl, cyclobutyl and cyclopentyl.

The term "halogen," either alone or in compound words such as "haloalkyl," denotes fluorine, chlorine, bromine or iodine. Further, when used in compound words such as "haloalkyl" said alkyl may be partially halogenated or fully substituted with halogen atoms and said halogen atoms may be the same or different. Examples of haloalkyl include CH₂ CH₂ F, CF₂ CF₃ and CH₂ CHFCl.

The total number of carbon atoms in a substituent group is indicated by the C_(i) -C_(j) prefix where i and j are numbers from 1 to 5. For example, C₁ -C₃ alkylsulfonyl would designate methylsulfonyl through propylsulfonyl, C₂ alkoxyalkoxy would designate OCH₂ OCH₃, C₂ cyanoalkyl would designate CH₂ CN and C₃ cyanoalkyl would designate CH₂ CH₂ CN and CH(CN)CH₃.

Compounds of the invention preferred for reasons of increased ease of synthesis and/or greater herbicidal efficacy are:

1. Compounds of Formula I where L is L-1, , L-3, L-4a, L-4b, L-5, L-6, L-7, L-10, L-11, L-14, L-16, L-19 or L-20.

2. Compounds of Preferred 1 where W is O and Z⁴ is CH or N.

3. Compounds of Preferred 2 where

X is C₁ -C₂ alkyl, C₁ -C₂ alkoxy, Cl, F, Br, I, OCF₂ H, CH₂ F, CF₃, OCH₂ CH₂ F, OCH₂ CHF₂, OCH₂ CF₃, CH₂ Cl or CH₂ Br;

Y is H, C₁ -C₂ alkyl, C₁ -C₂ alkoxy, CH₂ OCH₃, CH₂ OCH₂ CH₃, NHCH₃, N(OCH₃)CH₃, N(CH₃)₂, CF₃, SCH₃, OCH₂ CH═CH₂, OCH₂ C.tbd.CH, OCH₂ CH₂ OCH₃, CH₂ SCH₃, ##STR25## OCF₂ H, OCF₂ Br, SCF₂ H, cyclopropyl, C.tbd.CH or C.tbd.CCH₃ ;

R_(a) is H or CH₃ ; and

R_(b) and R_(c) are independently CH₃ or CH₂ CH₃.

4. Compounds of Preferred 3 where

R¹ is H, halogen, C₁ -C₂ alkyl, C₁ -C₂ haloalkyl, OR⁶, SR⁶, S(O)R⁶, S(O)₂ R⁶, CO₂ R⁷, C(O)NR⁸ R⁹, S(O)₂ NR¹⁰ R¹¹, C₂ -C₃ alkenyl, C₂ -C₃ haloalkenyl, NO₂, CN, C(O)R¹², C(R¹³)═NOR¹⁴ or C₁ -C₂ alkyl substituted by C₁ -C₂ alkoxy, C₁ -C₂ alkylthio or CN;

R² is H, CH₃ or OCH₃ ;

R⁵ is H, halogen, C₁ -C₂ alkyl,

C₁ -C₂ haloalkyl, OR⁶, SR⁶, S(O)R⁶, S(O)₂ R⁶, CO₂ R⁷, C(O)NR⁸ R⁹, S(O)₂ NR¹⁰ R¹¹, C₂ -C₃ alkenyl, C₂ -C₃ haloalkenyl, NO₂, CN, C(O)R¹², or C₁ -C₂ alkyl substituted by C₁ -C₂ alkoxy, C₁ -C₂ alkylthio or CN;

R⁶ is C₁ -C₃ alkyl, C₁ -C₃ haloalkyl, C₃ alkenyl, C₂ -C₃ haloalkenyl, propargyl, cycloproyl or cyclopropylmethyl.

5. Compounds of Preferred 4 where

A is A-1;

X is CH₃, OCH₃, OCH₂ CH₃, Cl or OCF₂ H;

Y is CH₃, OCH₃, C₂ H₅, CH₂ OCH₃, NHCH₃, CH(OCH₃)₂ or cyclopropyl; and

R is H.

6. Compounds of Preferred 5 where L is L-1.

7. Compounds of Preferred 5 where L is L-3.

8. Compounds of Preferred 5 where L is L-4a.

9. Compounds of Preferred 5 where L is L-4b.

10. Compounds of Preferred 5 where L is L-5.

11. Compounds of Preferred 5 where L is L-6.

12. Compounds of Preferred 5 where L is L-7.

13. Compounds of Preferred 5 where L is L-10.

14. Compounds of Preferred 5 where L is L-11.

15. Compounds of Preferred 5 where L is L-14.

16. Compounds of Preferred 5 where L is L-19.

17. Compounds of Preferred 5 where L is L-20.

The compounds of this invention are active are active preemergent and postemergent herbicides and plant growth regulants.

DETAILED DESCRIPTION OF THE INVENTION Synthesis

Compounds of Formula I can be prepared by one or more of the procedures shown in Equations 1, 4, and 5 wherein L, R, and A are as previously defined. The requisite intermediates for these reactions can be prepared by one or more of the methods described in this section. In some cases, substituents on the starting materials may be incompatible with the reaction conditions described. It will be readily apparent to one skilled in the art to use either standard protecting groups (e.g., ketal as a protecting group for ketone) or one of the alternative methods described. ##STR26##

The reaction of Equation 1 is best carried out in an inert aprotic organic solvent such as dichloromethane, 1,2-dichloroethane, tetrahydrofuran, or acetonitrile, at a temperature between 20° and 85° C. The order of addition is not critical; however, it is often convenient to add the sulfonyl isocyanate or a solution of it in the reaction solvent, to a stirred suspension of the amine.

In some cases, the desired product is insoluble in the reaction solvent at ambient temperature and crystallizes from it in pure form. Products soluble in the reaction solvent are isolated by evaporation of the solvent. Compounds of Formula I then may be purified by trituration of the evaporation residue with solvents such as 1-chlorobutane or ethyl ether and filtration, by recrystallization from mixtures of solvents such as 1,2-dichloroethane, 1-chlorobutane and heptane or by chromatography on silica gel.

Sulfonyl isocyanates (II, W is O) can be prepared from the corresponding sulfonamides (IV) by one of the following two general methods. ##STR27##

The sulfonamide IV is reacted with an alkyl isocyanate (e.g., n-butyl isocyanate) in a solvent whose boiling point is above 135° C., such as xylene. The reaction can optionally be carried out in the presence of a catalytic amount of 1,4-diaza[2.2.2]bicyclooctane (DABCO). The reaction mixture is heated to 135°-140° C. and held at that temperature for 5-60 minutes, after which phosgene is slowly added at such a rate that the temperature remains between 133° and 135° C. When the consumption of phosgene has ceased, the mixture is cooled and filtered to remove insoluble material. Finally, the solvent, alkyl isocyanate, and excess phosgene are evaporated, leaving the sulfonyl isocyanate (II).

If desired, the alkyl isocyanate-sulfonamide adduct can be made and isolated before reaction with the phosgene. In this case the sulfonamide (IV), alkyl isocyanate, and anhydrous base (e.g. K₂ CO₃) or acetonitrile) are mixed and heated under reflux for 1 to 6 hours. The reaction mixture is then diluted with water, and the pH is adjusted to about 3 with acid (e.g. HCl, H₂ SO₄). The adduct is filtered out and dried, and then reacted with phosgene as described above. This procedure modification is especially useful with sulfonamide (IV) is high melting and has low solubility in the phosgenation solvent.

Sulfonyl isocyanates (II, W is O) can also be prepared by the following method. ##STR28##

The sulfonamide (IV) is heated at reflux in an excess of thionyl chloride. The reaction is continued until the sulfonamide protons are no longer detectable in the proton magnetic resonance spectrum. From 16 hours to 5 days is typically sufficient for complete conversion to the thionylamide (V) (Equation 3a).

The thionyl chloride is evaporated and the residue is treated with an inert solvent (e.g. toluene) containing at least one equivalent (typically 2-3 equivalents) of phosgene. A catalytic amount of pyridine (typically 0.1 equivalent) is added, and the mixture is heated to about 60°-140° C., with 80°-100° C. preferred. Conversion to the isocyanate (II, W is O) is usually substantially complete within 15 minutes to 3 hours (Equation 3b). The mixture is then cooled and filtered, and the solvent is evaporated, leaving the sulfonyl isocyanate (II, W is O).

Sulfonyl isothiocyanates (II, W is S) can be prepared from the corresponding sulfonamides (IV) by reaction with carbon disulfide and potassium hydroxide followed by treatment of the resulting dipotassium salt VI with phosgene. Such a procedure is described in Arch. Pharm., 299, 174 (1966).

Many of the compounds of Formula I can be prepared by the procedure shown in Equation 4. ##STR29##

The reaction of Equation 4 can be carried out by contacting phenylcarbamates or phenylthiocarbamates of Formula VI with aminoheterocycles of Formula III in an inert organic solvent such as dioxane or tetrahydrofuran at temperatures of about 20°-100° C. for a period of about one-half to twenty-four hours. The product can be isolated by evaporation of the reaction solvent and purified by methods previously described.

Phenylcarbamates and phenylthiocarbamates of Formula VI can be prepared by the methods described, or modifications thereof known to those skilled in the art, in U.S. Pat. No. 4,443,243.

Alternatively, many of the compounds of Formula I can be prepared by the method described in Equation 5. ##STR30##

The reaction of Equation 5 can be carried out by contacting equimolar amounts of a sulfonamide of Formula IV with a heterocyclic phenylcarbamate or phenylthiocarbamate of Formula VII in the presence of a base such as 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU), by methods analogous to those described in South African Patent Application 83/0441. The phenylcarbamates and phenylthiocarbamates of Formula VII can be prepared by methods, or modifications thereof known to those skilled in the art, described in South African Patent Application 82/5671 and South African Patent Application 82/5045.

The sulfonamides IV of this invention may be prepared in a variety of ways some of which are described in Equations 6 through 15.

The sulfonamides IV of this invention can be prepared from the corresponding sulfonyl chloride of Formula VIII. The preparation of sulfonamides from sulfonyl chlorides is widely reported in the literature; for reviews see: F. Hawking and J. S. Lawrence. "The Sulfonamides". H. K. Lewis and Co., London, 1950, and E. H. Northey, "The Sulfonamides and Allied Compound", Reinhold Publishing Corp., New York, 1984.

    L--SO.sub.2 Cl                                             VIII

The requisite sulfonyl chloride of Formula VIII may be synthesized from IX, X, or XI by known methods or with slight modification thereof, by one skilled in the art. ##STR31## wherein L is as previously defined. U is Cl, Br or I

L' is L-1, L-2, L-3, L-4a, L-4b, L-5, L-6, L-7, L-10, L-11, L-12, L-13, L-19 or L-20.

Several representative teaching are listed below.

Aromatic nitro group may be transformed into sulfonyl chloride by reduction, diazotization and coupling with sulfur dioxide/cupric chloride as taught in U.S. Pat. No. 4,310,346.

European Publication No. 94,821 (published 11/23/83) describes the displacement of aromatic halide with thiolate anions and subsequent oxidative chlorination to yield sulfonyl chlorides.

Halogen metal exchange of aromatic halides or proton-metal exchange of aromatic followed by quenching with sulfur dioxide give sulfinate salts.

These salts yield sulfonyl chlorides upon reaction with N-chlorosuccinimide as taught in U.S. Pat. No. 4,481,029 (issued 11/6/84).

Directed proton-metal exchange of aromatic compounds has been reviewed by Gschweard and Rodriquez, Org. Reactions, 26, (1979). Also aryllithiums may be converted directly to arylsulfonyl chloride with sulfonyl chloride as described by S. N. Bhattacharya, et. al, in J. Chem. Soc. C., 1265 (1968).

Electrophilic chlorosulfonation of an aromatic ring to give a sulfonyl chloride is well known in the literature. Its application is described by E. H. Huntress, et al., in J. Am. Chem. Soc., 62, 511-14 and 603-4 (1940), and W. E. Kirkpatrick, et al., in J. Med. Chem., 20, 386 (1977).

The compounds of Formula XI, where L' is L-1, L-2, L-3, L-4a, L-4b, L-5, L-6, L-7, L-10, L-11, L-12, L-13 L-19 or L-20, may be synthesized from compounds of Formula IX by nitration as taught by B. M. Lynch, et al., in Can. J. Chem., 53, 119 (1975), W. E. Kirkpatrick, et al., in J. Med. Chem., 20, 386 (1977) and B. Stanovnik in Lect. Heterocyclic. Chem., 2, 27.

The compounds of Formula IX₁, can be synthesized by the methods shown below in Equation 6 through 10. ##STR32## wherein R¹, R², R³ and Z are as previously defined.

Equation 6 illustrates the reaction of β-dicarbonyl compounds of Formula XII (or their equivalent) with an aminopyrazole of Formula XIII₁ to give the desired heterocycles of Formula IX₁ Z is CH, ##STR33## wherein R¹ is as previously defined, R^(2') is H, C₁ -C₃ alkyl or C₁ -C₂ alkyl substituted with OCH₃, SCH₃ or CN; R^(3') is H or CH₃.

The reaction of Equation 6 is best carried out under the conditions taught by W. E. Kirkpatrick, et al., in J. Med. Chem., 20, 386 (1977), J. S. Bajwa, et al., in J. Chem. Soc. Perkin I., 3085 (1979) and B. M. Lynch, et al., in Can. J. Chem., 53, 119 (1975).

Equation 7 illustrates the reaction of aminopyrazole of Formula XIII₁ with compounds of Formula XIV to give the desired heterocycles of Formula IX₁, Z is N. ##STR34## wherein R¹, R^(2'), and R^(3') are as previously defined; and

R₃₆ is C₁ -C₄ alkyl.

The reaction of Equation 7 is best carried out in an inert solvent such as toluene in the presence of an acid such as p-toluenesulfonic acid at a temperature between about 0° C. to 111° C. The products may be isolated by washing the reaction solution with an aqueous sodium carbonate solution, drying (MgSO₄) and concentrating the reaction solution. Crystallization and chromatography may be used for further purification of the products.

Equation 8 illustrates the reaction of aminopyrazole of Formula XIII₁, with an imidate of Formula XV to give the amidines of Formula XVI and the reaction of the amidines of Formula XVI with ortho esters of Formula XVII to give the desired heterocycles of Formula IX, Z is N. ##STR35## wherein R¹, R^(2'), and R^(3') and R₃₆ are as previously defined and

R₃₇ is C₁ -C₄ alkyl.

The reaction of Equation 8 is best carried out under the conditions taught by Keitara Senga, et al., in J. Med. Chem., 25, 243 (1982).

Compounds of Formula IX₁ (R³ is OCH₃) can be prepared as shown below in Equation 9 by reaction of chlorosubstituted heterocycles of Formula XVIII with methoxides of Formula XIX. ##STR36## wherein R¹ and R² are as previously defined; M is Na or K.

The reaction of Equation 9 is best carried out in an inert solvent such as dimethylformamide or an alcohol. The products may be isolated by evaporating the reaction solution and washing the residue with water. Chromatography may be used for further purification of the products.

Compounds of Formula IX₁, (R² is R^(2")), can be prepared as shown below in Equation 10 by reacting chlorosubstituted heterocycles of Formula XX with nucleophiles of Formula ⁻ R^(2"). ##STR37## wherein R¹, R³, and Z are as previously defined; R^(2") is C₁ -C₃ alkoxy, or C₁ -C₂ haloalkoxy.

The reaction of Equation 10 is best carried out in an inert solvent such as dimethylformamide or an alcohol. The products can be isolated by evaporating the reaction solvent and washing the residue with water. Chromatography may be used for further purification of the products.

Compounds XVIII and XX can be prepared from dichloroheterocycles of Formula XXI by nucleophilic displacement reactions with an appropriate nucleophile by methods in the art or by obvious modifications of these known methods. ##STR38## wherein

Z and R¹ are as previously defined.

Alternatively, they can be prepared by reacting the corresponding hydroxy compounds of Formula XXII or XXIII with POCl₃ or by other well-known methods or by obvious modification of these known methods. ##STR39## wherein Z, R¹, R² and R³ are as previously defined.

Compounds XXI can be prepared by reacting the corresponding dihydroxy compounds of Formula XXIV with POCl₃ by methods well known in the art. ##STR40## wherein R¹ and Z are as previously defined.

The compounds XXII (Z is C--H). XXIII (Z is C--H) or XXIV (Z is C--H) can be prepared by condensation of a β-keto ester, a malonatediester or one of their equivalents with 3-amino-pyrazoles of Formula XIII, as taught by:

1. Yasuo Makisumi in Chem. Pharm. Bull., 10, 612 (1962);

2. Keitara Senga et al. in J. Med. Chem., 24 (5), 61a (1971);

3. Alfred Dornow and Klaus Dehmer in Chem. Ber., 100 (8), 2577 (1967);

4. Mohamed Elnagdi in Arch. Pharm., 316 (8), 713 (1983);

5. B. B. Gavrilenko in Zh. Org. Khim., 18 (5), 1079 (1982);

or by modifications of these methods (e.g., reaction of 3-amino-pyrazoles of Formula XIII, with diketene).

The compounds XXII (Z is N), XXIII (Z is N) or XXIV (Z is N) can be similarly prepared by condensation of carbonylisocyanates of Formula XXV or the compounds of Formula XXVI with aminopyrazoles of Formula XIII₁. ##STR41## wherein J is H, Cl, CH₃, C₁ -C₄ alkoxy,

R², R₃₆ and R₃₇ are as previously defined.

The haloheterocycles of Formula X₁ can be synthesized by the same methods as those for the preparation of the heterocycles of Formula IX₁ using the aminohalopyrazoles of Formula XXVII₁ instead of the aminopyrazoles of Formula XIII₁ as starting material. ##STR42## wherein R¹, R², R³, U and Z are as previously defined.

Alternatively, the haloheterocycles of Formula X₁ can be synthesized by halogenation of the heterocycles of Formula IX₁ with a halogenating agent such as bromine, N-bromosuccinimide, chlorine, N-chlorosuccinimide or iodine as shown in Equation 11. ##STR43## wherein R¹, R², R³, Z and U are as previously defined.

The reaction of Equation 11 is best carried out in an inert solvent such as chloroform or carbon tetrachloride at a temperature between 0° C. to 77° C. The products can then be isolated by filtration, concentration of the filtrate and washing the residue with water. Crystallization or chromatography may be used for further purification if desired.

By similar methods as discussed for the preparation of the heterocycles of Formula IX₁ and the haloheterocycles of Formula X₁ from the aminopyrazoles of Formula XIII₁ and the aminohalopyrazoles of Formula XXVII₁, following compounds can be prepared:

The heterocycles of Formula IX₂ and the haloheterocycles of Formula X₂ can be prepared from the amino triazoles of Formula XIII₂ and the aminohalotriazoles of Formula XXVII₂ ;

The heterocycles of Formula IX₃ and the haloheterocycles of Formula X₃ can be prepared from the aminoimidazoles of Formula XIII₃ and the aminohaloimidazoles of Formula XXVII₃ ;

The heterocycles of Formula IX₄ and the haloheterocycles of Formula X₄ can be prepared from the N-aminoazoles of Formula XIII₄ and the N-aminohaloazoles of Formula XXVII₄ ;

The heterocycles of Formula IX₅ (where Z¹ is CH or CCH₃) and the haloheterocycles of Formula X₅ can be prepared from the N-aminoazoles of Formula XIII₅ (where Z¹ is CH or CCH₃) and the N-aminohaloazoles of Formula XXVII₅. ##STR44## wherein R¹, R², R³, R⁴, Z and N are as previously defined.

The haloheterocycles of Formula X₂, X₃, X₄, and X₅, can also be prepared by halogenation of the heterocycles of Formula IX₂, IX₃, IX₄ and IX₅.

The heterocycles of Formula IX₄ (Z¹ is N,) can also be prepared by the reaction of compounds of Formula XXXXIII with orthoformate as shown below in Equation 12. ##STR45## wherein R², R³ and Z are as previously defined and

R is lower alkyl.

The reaction of Equation 12 is best carried out in an inert solvent such as toluene at a temperature between about 0° C. to 120° C. The product can be isolated by evaporation of the reaction solvent and orthoformate. Crystallization of chromatography may be used for further purification of the products.

The heterocycles of Formula IX₅ (Z₁ is N,) can be prepared by the reaction of compounds of Formula XXXXIV with an α-halocarbonyl compound of Formula XXXXV as shown in Equation 13. ##STR46## wherein R¹, R², R³, Z and V are as previously defined.

The reaction of Equation 13 is best carried out in an inert solvent such as N,N-dimethylformamide at a temperature between about 0° C. to 160° C. The products can be isolated by evaporation of the reaction solvent and washing the residue with other solvent such as hexane or ether. Crystallization or chromatography may be used for further purification, if desired.

The heterocycles of Formula IX₆ can be prepared from compounds of Formula XXVIII. For example, reaction of some of the compounds of Formula XXVIII with 2,3-butadione gives the desired products of Formula IX₆ (R₂ is CH₃, R₃ is CH₃) as shown below in Equation 14. ##STR47## wherein R², R³, and R⁴ are as previously defined. ##STR48## wherein R⁴ is as previously defined.

The reaction of Equation 14 is best carried out in an inert solvent such as toluene in the presence of an acid catalyst such as p-toluenesulfonic acid, if necessary, at a temperature between 0° C. and 120° C. The products may be isolated by evaporation of solvent, followed by chromatography or recrystallization of the residue.

The haloheterocycles of Formula X₆ can be synthesized by the same method as those for the preparation of the heterocycles of Formula IX₆ using the halocompounds of Formula XXIX instead of the compounds of Formula XXVIII as starting material. ##STR49## wherein R², R³, R⁴ and U are as previously defined.

Alternatively the haloheterocycles of Formula X₆ can be prepared by halogenation of the heterocycles of Formula IX₆ with a halogenating agent such as bromine, N-bromosuccinimide, chlorine, N-chlorosuccinimide or iodine.

The heterocycles of Formula IX₇ and the haloheterocycles of Formula X₇ can be synthesized from compounds of Formula XXX and Formula XXXI by the same methods as those for the preparation of compounds of Formula IX₆ and X₆ from compounds of Formula XXVIII and Formula XXIX. ##STR50## wherein R¹, R², R³, R⁴ and U are as previously defined.

The heterocycles of Formula IX₁₉ can be synthesized from the aminoheterocycles of Formula XXXII by similar methods as discussed for the preparation of the heterocycles of Formula IX₁ from aminopyrazole of Formula XIII₁. For example, reaction of the aminoheterocycles of Formula XXXII with a β-dicarbonyl compound of Formula XXII should give the desired heterocycles of Formula IX₁₉ (R² is R^(2'), R³ is R^(3') and Z is C-H) as shown below in Equation 15. ##STR51## wherein R^(2'), R^(3'), and Z² are as previously defined.

The reaction of Equation 15 is best carried out under the conditions taught by A. Z. Britten, et al. in Chem. Ind., 6, 278 (1973).

Reaction of compounds of Formula XXXIII with HCO₂ NH₄ gives the desired heterocycles of Formula IX₁₉ (Z is N, R² is CH₃, R³ is CH₃) as shown in Equation 16. ##STR52##

The reaction of Equation 14 is best carried out under the conditions taught by Guy Ah-Kon, et al., in C. R. Acad. Sci., Ser. C., 278 (26), 1513 (1974).

The haloheterocycles of Formula X₁₉ can be synthesized from starting materials such as compounds of Formula XXXIV and XXXV in the same way as for the preparation of the heterocycles of Formula IX₁₉ from compounds of Formula XXXII and Formula XXXIII. Alternatively, compounds of Formula IX₁₉ can be converted to the haloheterocycles of Formula X₁₉ by halogenation.

The haloheterocycles of Formula X₂₀ can be prepared from starting materials such as compounds of Formula XXXVI and formula XXXVII by similar chemistry as taught previously for the preparation of heterocycles of Formula IX₁₉.

The heterocycles of Formula IX₂₀ can be synthesized by dehalogenating the haloheterocycles of Formula X₂₀. ##STR53## wherein R², R³, Z, Z³ and U are as previously defined.

The haloheterocycles of Formula X₁₄ can be prepared from compounds of Formula XXXVIII. For example, reaction of compounds of Formula XXXVIII with triethylorthoacetate gives the desired haloheterocycles of Formula X₁₄ (R² is CH₃) as shown in Equation 17. ##STR54## wherein R¹, R⁴, and U are as previously defined.

The reaction of Equation 17 is best carried out in an inert solvent such as acetic acid at a temperature between 20° C. to 118° C. The products may be isolated by evaporation of the solvent, followed by chromatography or crystallization of the residue.

By similar methods as those described for the preparation of haloheterocycles of Formula X₁₄ from compounds of Formula XXXVIII, the following haloheterocycles can be prepared:

The haloheterocycles of Formula X₁₅ can be prepared from compounds of Formula XXXIX.

The haloheterocycles of Formula X₁₆ can be prepared from compounds of Formula XXXX.

The haloheterocycles of Formula X₁₇ can be prepared from compounds of Formula XXXXI.

The haloheterocycles of Formula X₁₈ can be prepared from the compounds of Formula XXXXII. ##STR55## wherein R¹, R², R⁴, Z¹ and U are as previously defined.

Heterocycles of Formula IX₁₀ can be synthesized by literature methods (or by modification of these methods) such as those taught by:

T. Tsuchiya, et al., in Chem. Pharm. Bull., 31, 4568 (1983).

A. Kakehi, et al., in J. Org. Chem., 42, 443 (1977).

T. Tsuchiya, et al., in J. Chem. Soc., Chem. Commun., 1109 (1980).

A. Ohsawa, et al., in J. Org. Chem., 47, 3497 (1982).

D. E. Kuhla, et al., in "Adv. Heterocycle Chem.", 21, 1-63 (1977).

U. Burger, et al., in Helv. Chim. Acta., 62, 540 (1975).

A. Kakehi, et al., in J. Org. Chem., 43, 4837 (1978).

G. Maury, et al., in Chem. Heterocycl. Compd., 30, 179 (1977).

H. L. Blewitt in Chem. Heterocycl. Compd., 30, 117 (1977).

T. Uchida, et al., in Synthesis, 209 (1976)

E. Kranz, et al., in Ger. Offen. 2220186 (published Nov. 8, 1973), Ger. Offen. 2058500 (published May 31, 1972) and in Chem. Ber., 105 (1972)

The haloheterocycles of Formula X₁₀ can be synthesized by halogenating the heterocycles of Formula IX₁₀ with halogenating agents. ##STR56## wherein R¹, R², R³, R⁵, Z, Z¹ and U are as previously defined.

The heterocycles of Formula IX₁₁ can be synthesized by literature methods (or by modification of these methods) such as those taught by K. Kasuga, et al., in Yakugaka Zasshi., 94, 952 (1974), M. Muehlstaedt, et al., in J. Prakt. Chem., 311, 363 (1969), and D. E. Kuhla, et al., in Adv. Heterocycl. Chem., 21, (1977).

Jpn. Kokai 84/2053801 also describes the synthesis of some heterocycles of Formula IX₁₁. The haloheterocycles of Formula X₁₁ can be prepared by halogenating the heterocycles of Formula IX₁₁ ##STR57## wherein R¹, R³, Rhu 5, Z¹ and U are as previously defined.

The heterocycles of Formula IX₁₂ can be synthesized by literature methods (or by modification of these methods) such as those taught by G. Maury, et al., in J. Heterocycl. Chem., 15, 1041 (1978), C. Wentrup in Helv. Chim. Acta., 61, 1755 (1978), S. Mineo, et al., in Synth. Commun., 6, 69 (1976) and Y. Tamura, et al., in J. Heterocycl. Chem., 12, 481 (1975).

X₁₂ can be prepared by halogenation of the heterocycles of Formula IX₁₂ with halogenating agents. ##STR58##

Heterocycles of Formula IX₁₃ can be synthesized by literature methods (or by modification of these methods) such as those taught by G. Maury, et al., in Bull. Soc., Chim. Belg., 91, 153 (1982) and C. Wentrup in Helv. Chim. Acta., 61, 1755 (1978). The haloheterocycles of Formula X₁₃ can be prepared by halogenation of the heterocycles of Formula IX₁₃. ##STR59##

The intermediates of Formula XII, XIII₁, XIV, XV, XXV, XXVI, XXVII₁, XIII₂, XIII₃, XXVII₃, XIII₄, XXVII₄, XIII₅, XXVII₅, XXVIII, XXIX, XXX, XXXI, XXXII, XXXIII, XXXIV, XXXV, XXXVI, XXXVII, XXXVIII, XXXIX, XXXX, XXXXI, XXXXII, XXXXIII, XXXXIV and XXXXV can be prepared by methods known in the art or by obvious modification of these known methods.

The synthesis of heterocyclic amines such as those represented by Formula III has been reviewed in "The Chemistry of Heterocyclic Compounds," a series published by Interscience Publ., New York and London. Aminopyrimidines are described by D. J. Brown in "The Pyrimidines," Vol. XVI of the series mentioned above which is herein incorporated by reference. The 2-amino-1,3,5-triazines of Formula III, where A is A-1 and Z⁴ is N, can be prepared according to methods described by E. M. Smolin and L. Rappaport in "s-Triazines and Derivatives," Vol. XIII.

Pyrimidines of Formula III, where A is A-1 and Y is an acetal or thioacetal substituent, can be prepared by methods taught in European Patent Application No. 84,224 (published July 27, 1983).

Pyrimidines of Formula III, where A is A-1 and Y is cyclopropyl or OCF₂ H can be synthesized according to the methods taught in U.S. Pat. No. 4,515,626 and U.S. Pat. No. 4,540,782, respectively.

Compounds of Formula III, where A is A-2 or A-3, can be prepared by procedures disclosed in U.S. Pat. No. 4,339,267.

Compounds of Formula III, where A is A-4, can be prepared by methods taught in U.S. Pat. No. 4,487,626.

Additional references dealing with the synthesis ob bicyclic pyrimidines of Formula III, where A is A-2, A-3, or A-4 are Braker, Sheehan, Spitzmiller and Lott, J. Am. Chem. Soc., 69, 3072 (1947); Mitler and Bhattacharya, Quart. J. Indian Chem. Soc., 4, 152 (1927); Shrage and Hitchings, J. Org. Chem., 16, 1153 (1951); Caldwell, Kornfeld annd Donnell, J. Am. Chem. Soc., 63, 2188 (1941); and Fissekis, Myles and Brown, J. Org. Chem., 29, 2670 (1964).

Compounds of Formula III, where A is A-5, can be prepared by methods taught in the U.S. Pat. No. 4,421,550.

Compounds of Formula III, where A is A-6, can be prepared by methods taught in the U.S. Pat. No. 4,496,392. ##STR60##

                  TABLE 1                                                          ______________________________________                                         General Formula 1                                                              R.sup.1   R.sup.2                                                                               R.sup.3                                                                               R     X     Y      Z.sup.4                             ______________________________________                                         H         CH.sub.3                                                                              CH.sub.3                                                                              H     OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                  H         CH.sub.3                                                                              CH.sub.3                                                                              H     OCH.sub.3                                                                            CH.sub.3                                                                              CH                                  H         CH.sub.3                                                                              CH.sub.3                                                                              H     Cl    OCH.sub.3                                                                             CH                                  H         CH.sub.3                                                                              CH.sub.3                                                                              H     CH.sub.3                                                                             CH.sub.3                                                                              CH                                  H         CH.sub.3                                                                              CH.sub.3                                                                              H     OCH.sub.3                                                                            OCH.sub.3                                                                             N                                   H         CH.sub.3                                                                              CH.sub.3                                                                              H     OCH.sub.3                                                                            CH.sub.3                                                                              N                                   H         CH.sub.3                                                                              CH.sub.3                                                                              H     OC.sub.2 H.sub.5                                                                     NHCH.sub.3                                                                            N                                   H         CH.sub.3                                                                              CH.sub.3                                                                              CH    OCH.sub.3                                                                            CH.sub.3                                                                              N                                   Cl        CH.sub.3                                                                              CH.sub.3                                                                              H     OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                  Cl        CH.sub.3                                                                              CH.sub.3                                                                              H     OCH.sub.3                                                                            CH.sub.3                                                                              CH                                  Cl        CH.sub.3                                                                              CH.sub.3                                                                              H     Cl    OCH.sub.3                                                                             CH                                  Cl        CH.sub.3                                                                              CH.sub.3                                                                              H     CH.sub.3                                                                             CH.sub.3                                                                              CH                                  Cl        CH.sub.3                                                                              CH.sub.3                                                                              H     OCH.sub.3                                                                            OCH.sub.3                                                                             N                                   Cl        CH.sub.3                                                                              CH.sub.3                                                                              H     OCH.sub.3                                                                            CH.sub.3                                                                              N                                   Cl        CH.sub.3                                                                              CH.sub.3                                                                              H     OC.sub.2 H.sub.5                                                                     NHCH.sub.3                                                                            N                                   Cl        CH.sub.3                                                                              CH.sub.3                                                                              CH.sub.3                                                                             OCH.sub.3                                                                            CH.sub.3                                                                              N                                   SO.sub.2 CH.sub.3                                                                        CH.sub.3                                                                              CH.sub.3                                                                              H     OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                  SO.sub.2 CH.sub.3                                                                        CH.sub.3                                                                              CH.sub.3                                                                              H     OCH.sub.3                                                                            CH.sub.3                                                                              CH                                  SO.sub.2 CH.sub.3                                                                        CH.sub.3                                                                              CH.sub.3                                                                              H     Cl    OCH.sub.3                                                                             CH                                  SO.sub.2 CH.sub.3                                                                        CH.sub.3                                                                              CH.sub.3                                                                              H     CH.sub.3                                                                             CH.sub.3                                                                              CH                                  SO.sub.2 CH.sub.3                                                                        CH.sub.3                                                                              CH.sub.3                                                                              H     OCH.sub.3                                                                            OCH.sub.3                                                                             N                                   SO.sub.2 CH.sub.3                                                                        CH.sub.3                                                                              CH.sub.3                                                                              H     OCH.sub.3                                                                            CH.sub.3                                                                              N                                   SO.sub.2 CH.sub.3                                                                        CH.sub.3                                                                              CH.sub.3                                                                              H     OC.sub.2 H.sub.5                                                                     NHCH.sub.3                                                                            N                                   SO.sub.2 CH.sub.3                                                                        CH.sub.3                                                                              CH.sub.3                                                                              CH.sub.3                                                                             OCH.sub.3                                                                            CH.sub.3                                                                              N                                   SO.sub.2 N(CH.sub.3).sub.2                                                               CH.sub.3                                                                              CH.sub.3                                                                              H     OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                  SO.sub.2 N(CH.sub.3).sub.2                                                               CH.sub.3                                                                              CH.sub.3                                                                              H     OCH.sub.3                                                                            CH.sub.3                                                                              CH                                  SO.sub.2 N(CH.sub.3).sub.2                                                               CH.sub.3                                                                              CH.sub.3                                                                              H     Cl    OCH.sub.3                                                                             CH                                  SO.sub.2 N(CH.sub.3).sub.2                                                               CH.sub.3                                                                              CH.sub.3                                                                              H     OCH.sub.3                                                                            OCH.sub.3                                                                             N                                   SO.sub.2 N(CH.sub.3).sub.2                                                               CH.sub.3                                                                              CH.sub.3                                                                              H     OCH.sub.3                                                                            CH.sub.3                                                                              N                                   H         H      H      H     OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                  H         H      H      H     OCH.sub.3                                                                            CH.sub.3                                                                              CH                                  H         H      H      H     Cl    OCH.sub.3                                                                             CH                                  H         H      H      H     CH.sub.3                                                                             CH.sub.3                                                                              CH                                  H         H      H      H     OCH.sub.3                                                                            OCH.sub.3                                                                             N                                   H         H      H      H     OCH.sub.3                                                                            CH.sub.3                                                                              N                                   H         H      H      H     OC.sub.2 H.sub.5                                                                     NHCH.sub.3                                                                            N                                   H         H      H      CH.sub.3                                                                             OCH.sub.3                                                                            CH.sub.3                                                                              N                                   Cl        H      H      H     OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                  Cl        H      H      H     OCH.sub.3                                                                            CH.sub.3                                                                              CH                                  Cl        H      H      H     Cl    OCH.sub.3                                                                             CH                                  Cl        H      H      H     CH.sub.3                                                                             CH.sub.3                                                                              CH                                  Cl        H      H      H     OCH.sub.3                                                                            OCH.sub.3                                                                             N                                   Cl        H      H      H     OCH.sub.3                                                                            CH.sub.3                                                                              N                                   Cl        H      H      H     OC.sub.2 H.sub.5                                                                     NHCH.sub.3                                                                            N                                   Cl        H      H      CH.sub.3                                                                             OCH.sub.3                                                                            CH.sub.3                                                                              N                                   SO.sub.2 CH.sub.3                                                                        H      H      H     OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                  SO.sub.2 CH.sub.3                                                                        H      H      H     OCH.sub.3                                                                            CH.sub.3                                                                              CH                                  SO.sub.2 CH.sub.3                                                                        H      H      H     Cl    OCH.sub.3                                                                             CH                                  SO.sub.2 CH.sub.3                                                                        H      H      H     CH.sub.3                                                                             CH.sub.3                                                                              CH                                  SO.sub.2 CH.sub.3                                                                        H      H      H     OCH.sub.3                                                                            OCH.sub.3                                                                             N                                   SO.sub.2 CH.sub.3                                                                        H      H      H     OCH.sub.3                                                                            CH.sub.3                                                                              N                                   SO.sub.2 CH.sub.3                                                                        H      H      H     OC.sub.2 H.sub.5                                                                     NHCH.sub.3                                                                            N                                   SO.sub.2 CH.sub.3                                                                        H      H      CH.sub.3                                                                             OCH.sub.3                                                                            CH.sub.3                                                                              N                                   SO.sub.2 N(CH.sub.3).sub.2                                                               H      H      H     OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                  SO.sub.2 N(CH.sub.3).sub.2                                                               H      H      H     OCH.sub.3                                                                            CH.sub.3                                                                              CH                                  SO.sub.2 N(CH.sub.3).sub.2                                                               H      H      H     Cl    OCH.sub.3                                                                             CH                                  SO.sub.2 N(CH.sub.3).sub.2                                                               H      H      H     OCH.sub.3                                                                            OCH.sub.3                                                                             N                                   SO.sub.2 N(CH.sub.3).sub.2                                                               H      H      H     OCH.sub.3                                                                            CH.sub.3                                                                              N                                   H         H      CH.sub.3                                                                              H     OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                  H         H      CH.sub.3                                                                              H     OCH.sub.3                                                                            CH.sub.3                                                                              CH                                  H         H      CH.sub.3                                                                              H     Cl    OCH.sub.3                                                                             CH                                  H         H      CH.sub.3                                                                              H     CH.sub.3                                                                             CH.sub.3                                                                              CH                                  H         H      CH.sub.3                                                                              H     OCH.sub.3                                                                            OCH.sub.3                                                                             N                                   H         H      CH.sub.3                                                                              H     OCH.sub.3                                                                            CH.sub.3                                                                              N                                   H         H      CH.sub.3                                                                              H     OC.sub.2 H.sub.5                                                                     NHCH.sub.3                                                                            N                                   H         H      CH.sub.3                                                                              H     OCH.sub.3                                                                            CH.sub. 3                                                                             N                                   Cl        H      CH.sub.3                                                                              H     OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                  Cl        H      CH.sub.3                                                                              H     OCH.sub.3                                                                            CH.sub.3                                                                              CH                                  Cl        H      CH.sub.3                                                                              H     Cl    OCH.sub.3                                                                             CH                                  Cl        H      CH.sub.3                                                                              H     CH.sub.3                                                                             CH.sub.3                                                                              CH                                  Cl        H      CH.sub.3                                                                              H     OCH.sub.3                                                                            OCH.sub.3                                                                             N                                   Cl        H      CH.sub.3                                                                              H     OCH.sub.3                                                                            CH.sub.3                                                                              N                                   Cl        H      CH.sub.3                                                                              H     OC.sub.2 H.sub.5                                                                     NHCH.sub.3                                                                            N                                   Cl        H      CH.sub.3                                                                              CH.sub.3                                                                             OCH.sub.3                                                                            CH.sub.3                                                                              N                                   CO.sub.2 CH.sub.3                                                                        H      CH.sub.3                                                                              H     OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                  CO.sub.2 CH.sub.3                                                                        H      CH.sub.3                                                                              H     OCH.sub.3                                                                            CH.sub.3                                                                              CH                                  CO.sub.2 CH.sub.3                                                                        H      CH.sub.3                                                                              H     Cl    OCH.sub.3                                                                             CH                                  CO.sub.2 CH.sub.3                                                                        H      CH.sub.3                                                                              H     CH.sub.3                                                                             CH.sub.3                                                                              CH                                  CO.sub.2 CH.sub.3                                                                        H      CH.sub.3                                                                              H     OCH.sub.3                                                                            OCH.sub.3                                                                             N                                   CO.sub.2 CH.sub.3                                                                        H      CH.sub.3                                                                              H     OCH.sub.3                                                                            CH.sub.3                                                                              N                                   CO.sub.2 CH.sub.3                                                                        H      CH.sub.3                                                                              H     OC.sub.2 H.sub.5                                                                     NHCH.sub.3                                                                            N                                   CO.sub.2 CH.sub.3                                                                        H      CH.sub.3                                                                              CH.sub.3                                                                             OCH.sub.3                                                                            CH.sub.3                                                                              N                                   SO.sub.2 N(CH.sub.3).sub.2                                                               H      CH.sub.3                                                                              H     OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                  SO.sub.2 N(CH.sub.3).sub.2                                                               H      CH.sub.3                                                                              H     OCH.sub.3                                                                            CH.sub.3                                                                              CH                                  SO.sub.2 N(CH.sub.3).sub.2                                                               H      CH.sub.3                                                                              H     Cl    OCH.sub.3                                                                             CH                                  SO.sub.2 N(CH.sub.3).sub.2                                                               H      CH.sub.3                                                                              H     OCH.sub.3                                                                            OCH.sub.3                                                                             N                                   SO.sub.2 N(CH.sub.3).sub.2                                                               H      CH.sub.3                                                                              H     OCH.sub.3                                                                            CH.sub.3                                                                              N                                   H         CH.sub.3                                                                              H      H     OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                  H         CH.sub.3                                                                              H      H     OCH.sub.3                                                                            CH.sub.3                                                                              CH                                  H         CH.sub.3                                                                              H      H     Cl    OCH.sub.3                                                                             CH                                  H         CH.sub.3                                                                              H      H     CH.sub.3                                                                             CH.sub.3                                                                              CH                                  H         CH.sub.3                                                                              H      H     OCH.sub.3                                                                            OCH.sub.3                                                                             N                                   H         CH.sub.3                                                                              H      H     OCH.sub.3                                                                            CH.sub.3                                                                              N                                   H         CH.sub.3                                                                              H      H     OC.sub.2 H.sub.5                                                                     NHCH.sub.3                                                                            N                                   H         CH.sub.3                                                                              H      CH.sub.3                                                                             OCH.sub.3                                                                            CH.sub.3                                                                              N                                   Cl        CH.sub.3                                                                              H      H     OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                  Cl        CH.sub.3                                                                              H      H     OCH.sub.3                                                                            CH.sub.3                                                                              CH                                  Cl        CH.sub.3                                                                              H      H     Cl    OCH.sub.3                                                                             CH                                  Cl        CH.sub.3                                                                              H      H     CH.sub.3                                                                             CH.sub.3                                                                              CH                                  Cl        CH.sub.3                                                                              H      H     OCH.sub.3                                                                            OCH.sub.3                                                                             N                                   Cl        CH.sub.3                                                                              H      H     OCH.sub.3                                                                            CH.sub.3                                                                              N                                   Cl        CH.sub.3                                                                              H      H     OC.sub.2 H.sub.5                                                                     NHCH.sub.3                                                                            N                                   Cl        CH.sub.3                                                                              H      CH.sub.3                                                                             OCH.sub.3                                                                            CH.sub.3                                                                              N                                   SO.sub.2 CH.sub.3                                                                        CH.sub.3                                                                              H      H     OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                  SO.sub.2 CH.sub.3                                                                        CH.sub.3                                                                              H      H     OCH.sub.3                                                                            CH.sub.3                                                                              CH                                  SO.sub.2 CH.sub.3                                                                        CH.sub.3                                                                              H      H     Cl    OCH.sub.3                                                                             CH                                  SO.sub.2 CH.sub.3                                                                        CH.sub.3                                                                              H      H     CH.sub.3                                                                             CH.sub.3                                                                              CH                                  SO.sub.2 CH.sub.3                                                                        CH.sub.3                                                                              H      H     OCH.sub.3                                                                            OCH.sub.3                                                                             N                                   SO.sub.2 CH.sub.3                                                                        CH.sub.3                                                                              H      H     OCH.sub.3                                                                            CH.sub.3                                                                              N                                   SO.sub.2 CH.sub.3                                                                        CH.sub.3                                                                              H      H     OC.sub.2 H.sub.5                                                                     NHCH.sub.3                                                                            N                                   SO.sub.2 CH.sub.3                                                                        CH.sub.3                                                                              H      CH.sub.3                                                                             OCH.sub.3                                                                            CH.sub.3                                                                              N                                   SO.sub.2 N(CH.sub.3).sub.2                                                               CH.sub.3                                                                              H      H     OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                  SO.sub.2 N(CH.sub.3).sub.2                                                               CH.sub.3                                                                              H      H     OCH.sub.3                                                                            CH.sub.3                                                                              CH                                  SO.sub.2 N(CH.sub.3).sub.2                                                               CH.sub.3                                                                              H      H     Cl    OCH.sub.3                                                                             CH                                  SO.sub.2 N(CH.sub.3).sub.2                                                               CH.sub.3                                                                              H      H     OCH.sub.3                                                                            OCH.sub.3                                                                             N                                   SO.sub.2 N(CH.sub.3).sub.2                                                               CH.sub. 3                                                                             H      H     OCH.sub.3                                                                            CH.sub.3                                                                              N                                   CO.sub.2 CH.sub.3                                                                        CH.sub.3                                                                              CH.sub.3                                                                              H     OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                  CO.sub.2 CH.sub.3                                                                        CH.sub.3                                                                              CH.sub.3                                                                              H     OCH.sub.3                                                                            CH.sub.3                                                                              CH                                  CO.sub.2 CH.sub.3                                                                        CH.sub.3                                                                              CH.sub.3                                                                              H     Cl    OCH.sub.3                                                                             CH                                  CO.sub.2 CH.sub.3                                                                        CH.sub.3                                                                              CH.sub.3                                                                              H     CH.sub.3                                                                             CH.sub.3                                                                              CH                                  CO.sub.2 CH.sub.3                                                                        CH.sub.3                                                                              CH.sub.3                                                                              H     OCH.sub.3                                                                            OCH.sub.3                                                                             N                                   CO.sub.2 CH.sub.3                                                                        CH.sub.3                                                                              CH.sub.3                                                                              H     OCH.sub.3                                                                            CH.sub.3                                                                              N                                   CO.sub.2 CH.sub.3                                                                        CH.sub.3                                                                              CH.sub.3                                                                              H     OC.sub.2 H.sub.5                                                                     NHCH.sub.3                                                                            N                                   CO.sub.2 CH.sub.3                                                                        CH.sub.3                                                                              CH.sub.3                                                                              CH.sub.3                                                                             OCH.sub.3                                                                            CH.sub.3                                                                              N                                   CO.sub.2 CH.sub.3                                                                        CH.sub.3                                                                              H      H     OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                  CO.sub.2 CH.sub.3                                                                        CH.sub.3                                                                              H      H     OCH.sub.3                                                                            CH.sub.3                                                                              CH                                  CO.sub.2 CH.sub.3                                                                        CH.sub.3                                                                              H      H     Cl    OCH.sub.3                                                                             CH                                  CO.sub.2 CH.sub.3                                                                        CH.sub.3                                                                              H      H     CH.sub.3                                                                             CH.sub.3                                                                              CH                                  CO.sub.2 CH.sub.3                                                                        CH.sub.3                                                                              H      H     OCH.sub.3                                                                            OCH.sub.3                                                                             N                                   CO.sub.2 CH.sub.3                                                                        CH.sub.3                                                                              H      H     OCH.sub.3                                                                            CH.sub.3                                                                              N                                   CO.sub. 2 CH.sub.3                                                                       CH.sub.3                                                                              H      H     OC.sub.2 H.sub.5                                                                     NHCH.sub.3                                                                            N                                   CO.sub.2 CH.sub.3                                                                        CH.sub.3                                                                              H      CH.sub.3                                                                             OCH.sub.3                                                                            CH.sub.3                                                                              N                                   CO.sub.2 CH.sub.3                                                                        H      CH.sub.3                                                                              H     OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                  CO.sub.2 CH.sub.3                                                                        H      CH.sub.3                                                                              H     OCH.sub.3                                                                            CH.sub.3                                                                              CH                                  CO.sub.2 CH.sub.3                                                                        H      CH.sub.3                                                                              H     Cl    OCH.sub.3                                                                             CH                                  CO.sub.2 CH.sub.3                                                                        H      CH.sub.3                                                                              H     CH.sub.3                                                                             CH.sub.3                                                                              CH                                  CO.sub.2 CH.sub.3                                                                        H      CH.sub.3                                                                              H     OCH.sub.3                                                                            OCH.sub.3                                                                             N                                   CO.sub.2 CH.sub.3                                                                        H      CH.sub.3                                                                              H     OCH.sub.3                                                                            CH.sub.3                                                                              N                                   CO.sub.2 CH.sub.3                                                                        H      CH.sub.3                                                                              H     OC.sub.2 H.sub.5                                                                     NHCH.sub.3                                                                            N                                   CO.sub.2 CH.sub.3                                                                        H      CH.sub.3                                                                              CH.sub.3                                                                             OCH.sub.3                                                                            CH.sub.3                                                                              N                                   ______________________________________                                    

                  TABLE 2                                                          ______________________________________                                         General Formula 2                                                              Z     R.sup.2 R.sup.3 R     X      Y       Z.sup.4                             ______________________________________                                         CH    CH.sub.3                                                                               CH.sub.3                                                                               H     OCH.sub.3                                                                             OCH.sub.3                                                                              CH                                  CH    CH.sub.3                                                                               CH.sub.3                                                                               H     OCH.sub.3                                                                             CH.sub.3                                                                               CH                                  CH    CH.sub.3                                                                               CH.sub.3                                                                               H     Cl     OCH.sub.3                                                                              CH                                  CH    CH.sub.3                                                                               CH.sub.3                                                                               H     CH.sub.3                                                                              CH.sub.3                                                                               CH                                  CH    CH.sub.3                                                                               CH.sub.3                                                                               H     OCH.sub.3                                                                             OCH.sub.3                                                                              N                                   CH    CH.sub.3                                                                               CH.sub.3                                                                               H     OCH.sub.3                                                                             CH.sub.3                                                                               N                                   CH    CH.sub.3                                                                               CH.sub.3                                                                               H     OC.sub.2 H.sub.5                                                                      NHCH.sub.3                                                                             N                                   CH    CH.sub.3                                                                               CH.sub.3                                                                               CH.sub.3                                                                             OCH.sub.3                                                                             CH.sub.3                                                                               N                                   N     CH.sub.3                                                                               CH.sub.3                                                                               H     OCH.sub.3                                                                             OCH.sub.3                                                                              CH                                  N     CH.sub.3                                                                               CH.sub.3                                                                               H     OCH.sub.3                                                                             CH.sub.3                                                                               CH                                  N     CH.sub.3                                                                               CH.sub.3                                                                               H     Cl     OCH.sub.3                                                                              CH                                  N     CH.sub.3                                                                               CH.sub.3                                                                               H     CH.sub.3                                                                              CH.sub.3                                                                               CH                                  N     CH.sub.3                                                                               CH.sub.3                                                                               H     OCH.sub.3                                                                             OCH.sub.3                                                                              N                                   N     CH.sub.3                                                                               CH.sub.3                                                                               H     OCH.sub.3                                                                             CH.sub.3                                                                               N                                   N     CH.sub.3                                                                               CH.sub.3                                                                               H     OC.sub.2 H.sub.5                                                                      NHCH.sub.3                                                                             N                                   N     CH.sub.3                                                                               CH.sub.3                                                                               CH.sub.3                                                                             OCH.sub.3                                                                             CH.sub.3                                                                               N                                   CH    CH.sub.3                                                                               H       H     OCH.sub.3                                                                             OCH.sub.3                                                                              CH                                  CH    CH.sub.3                                                                               H       H     OCH.sub.3                                                                             CH.sub.3                                                                               CH                                  CH    CH.sub.3                                                                               H       H     Cl     OCH.sub.3                                                                              CH                                  CH    CH.sub.3                                                                               H       H     CH.sub.3                                                                              CH.sub.3                                                                               CH                                  CH    CH.sub.3                                                                               H       H     OCH.sub.3                                                                             OCH.sub.3                                                                              N                                   CH    CH.sub.3                                                                               H       H     OCH.sub.3                                                                             CH.sub.3                                                                               N                                   CH    CH.sub.3                                                                               H       H     OC.sub.2 H.sub.5                                                                      NHCH.sub.3                                                                             N                                   CH    CH.sub.3                                                                               H       CH.sub.3                                                                             OCH.sub.3                                                                             CH.sub.3                                                                               N                                   N     CH.sub.3                                                                               H       H     OCH.sub.3                                                                             OCH.sub.3                                                                              CH                                  N     CH.sub.3                                                                               H       H     OCH.sub.3                                                                             CH.sub.3                                                                               CH                                  N     CH.sub.3                                                                               H       H     Cl     OCH.sub.3                                                                              CH                                  N     CH.sub.3                                                                               H       H     CH.sub.3                                                                              CH.sub.3                                                                               CH                                  N     CH.sub.3                                                                               H       H     OCH.sub.3                                                                             OCH.sub.3                                                                              N                                   N     CH.sub.3                                                                               H       H     OCH.sub.3                                                                             CH.sub.3                                                                               N                                   N     CH.sub.3                                                                               H       H     OC.sub.2 H.sub.5                                                                      NHCH.sub.3                                                                             N                                   N     CH.sub.3                                                                               H       CH.sub.3                                                                             OCH.sub.3                                                                             CH.sub.3                                                                               N                                   CH    H       CH.sub.3                                                                               H     OCH.sub.3                                                                             OCH.sub.3                                                                              CH                                  CH    H       CH.sub.3                                                                               H     OCH.sub.3                                                                             CH.sub.3                                                                               CH                                  CH    H       CH.sub. 3                                                                              H     Cl     OCH.sub.3                                                                              CH                                  CH    H       CH.sub.3                                                                               H     CH.sub.3                                                                              CH.sub.3                                                                               CH                                  CH    H       CH.sub.3                                                                               H     OCH.sub.3                                                                             OCH.sub.3                                                                              N                                   CH    H       CH.sub.3                                                                               H     OCH.sub.3                                                                             CH.sub.3                                                                               N                                   CH    H       CH.sub.3                                                                               H     OC.sub.2 H.sub.5                                                                      NHCH.sub.3                                                                             N                                   CH    H       CH.sub.3                                                                               CH.sub.3                                                                             OCH.sub.3                                                                             CH.sub.3                                                                               N                                   N     H       CH.sub.3                                                                               H     OCH.sub.3                                                                             OCH.sub.3                                                                              CH                                  N     H       CH.sub.3                                                                               H     OCH.sub.3                                                                             CH.sub.3                                                                               CH                                  N     H       CH.sub.3                                                                               H     Cl     OCH.sub.3                                                                              CH                                  N     H       CH.sub.3                                                                               H     CH.sub.3                                                                              CH.sub.3                                                                               CH                                  N     H       CH.sub.3                                                                               H     OCH.sub.3                                                                             OCH.sub.3                                                                              N                                   N     H       CH.sub.3                                                                               H     OCH.sub.3                                                                             CH.sub.3                                                                               N                                   N     H       CH.sub.3                                                                               H     OC.sub.2 H.sub.5                                                                      NHCH.sub.3                                                                             N                                   N     H       CH.sub.3                                                                               CH.sub.3                                                                             OCH.sub.3                                                                             CH.sub.3                                                                               N                                   CH    H       H       H     OCH.sub.3                                                                             OCH.sub.3                                                                              CH                                  CH    H       H       H     OCH.sub.3                                                                             CH.sub.3                                                                               CH                                  CH    H       H       H     Cl     OCH.sub.3                                                                              CH                                  CH    H       H       H     CH.sub.3                                                                              CH.sub.3                                                                               CH                                  CH    H       H       H     OCH.sub.3                                                                             OCH.sub.3                                                                              N                                   CH    H       H       H     OCH.sub.3                                                                             CH.sub.3                                                                               N                                   CH    H       H       H     OC.sub.2 H.sub.5                                                                      NHCH.sub.3                                                                             N                                   CH    H       H       CH.sub.3                                                                             OCH.sub.3                                                                             CH.sub.3                                                                               N                                   N     H       H       H     OCH.sub.3                                                                             OCH.sub.3                                                                              CH                                  N     H       H       H     OCH.sub.3                                                                             CH.sub.3                                                                               CH                                  N     H       H       H     Cl     OCH.sub.3                                                                              CH                                  N     H       H       H     CH.sub.3                                                                              CH.sub.3                                                                               CH                                  N     H       H       H     OCH.sub.3                                                                             OCH.sub.3                                                                              N                                   N     H       H       H     OCH.sub.3                                                                             CH.sub.3                                                                               N                                   N     H       H       H     OC.sub.2 H.sub.5                                                                      NHCH.sub.3                                                                             N                                   N     H       H       CH.sub.3                                                                             OCH.sub.3                                                                             CH.sub.3                                                                               N                                   ______________________________________                                    

                  TABLE 3                                                          ______________________________________                                         General Formula 3                                                              R.sup.2 R.sup.3 R.sup.4                                                                               R     X     Y        Z.sup.4                            ______________________________________                                         CH.sub.3                                                                               CH.sub.3                                                                               H      H     OCH.sub.3                                                                            OCH.sub.3                                                                               CH                                 CH.sub.3                                                                               CH.sub.3                                                                               H      H     OCH.sub.3                                                                            CH.sub.3 CH                                 CH.sub.3                                                                               CH.sub.3                                                                               H      H     Cl    OCH.sub.3                                                                               CH                                 CH.sub.3                                                                               CH.sub.3                                                                               H      H     CH.sub.3                                                                             CH.sub.3 CH                                 CH.sub.3                                                                               CH.sub.3                                                                               H      H     OCH.sub.3                                                                            OCH.sub.3                                                                               N                                  CH.sub.3                                                                               CH.sub.3                                                                               H      H     OC.sub.2 H.sub.5                                                                     NHCH.sub.3                                                                              N                                  CH.sub.3                                                                               CH.sub.3                                                                               H      CH.sub.3                                                                             OCH.sub.3                                                                            CH.sub.3 N                                  CH.sub.3                                                                               H       H      H     OCH.sub.3                                                                            OCH.sub.3                                                                               CH                                 CH.sub.3                                                                               H       H      H     OCH.sub.3                                                                            CH.sub.3 CH                                 CH.sub.3                                                                               H       H      H     Cl    OCH.sub.3                                                                               CH                                 CH.sub.3                                                                               H       H      H     CH.sub.3                                                                             CH.sub.3 CH                                 CH.sub.3                                                                               H       H      H     OCH.sub.3                                                                            OCH.sub.3                                                                               N                                  CH.sub.3                                                                               H       H      H     OCH.sub.3                                                                            CH.sub.3 N                                  CH.sub.3                                                                               H       H      H     OC.sub.2 H.sub.5                                                                     NHCH.sub.3                                                                              N                                  CH.sub.3                                                                               H       H      CH.sub.3                                                                             OCH.sub.3                                                                            CH.sub.3 N                                  H       CH.sub.3                                                                               H      H     OCH.sub.3                                                                            OCH.sub.3                                                                               CH                                 H       CH.sub.3                                                                               H      H     OCH.sub.3                                                                            CH.sub.3 CH                                 H       CH.sub.3                                                                               H      H     Cl    OCH.sub.3                                                                               CH                                 H       CH.sub.3                                                                               H      H     CH.sub.3                                                                             CH.sub.3 CH                                 H       CH.sub.3                                                                               H      H     OCH.sub.3                                                                            OCH.sub.3                                                                               N                                  H       CH.sub.3                                                                               H      H     OCH.sub.3                                                                            CH.sub.3 N                                  H       CH.sub.3                                                                               H      H     OC.sub.2 H.sub.5                                                                     NHCH.sub.3                                                                              N                                  H       CH.sub.3                                                                               H      CH.sub.3                                                                             OCH.sub.3                                                                            CH.sub.3 N                                  H       H       H      H     OCH.sub.3                                                                            OCH.sub.3                                                                               CH                                 H       H       H      H     OCH.sub.3                                                                            CH.sub.3 CH                                 H       H       H      H     Cl    OCH.sub.3                                                                               CH                                 H       H       H      H     CH.sub.3                                                                             CH.sub.3 CH                                 H       H       H      H     OCH.sub.3                                                                            OCH.sub.3                                                                               N                                  H       H       H      H     OCH.sub.3                                                                            CH.sub.3 N                                  H       H       H      H     OC.sub.2 H.sub.5                                                                     NHCH.sub.3                                                                              N                                  H       H       H      CH.sub.3                                                                             OCH.sub.3                                                                            CH.sub.3 N                                  ______________________________________                                    

                  TABLE 4a                                                         ______________________________________                                         General Formula 4a                                                             Z.sup.1                                                                              R.sup.2 R.sup.3 R     X     Y        Z.sup.4                             ______________________________________                                         CH    CH.sub.3                                                                               CH.sub.3                                                                               H     OCH.sub.3                                                                            OCH.sub.3                                                                               CH                                  CH    CH.sub.3                                                                               CH.sub.3                                                                               H     OCH.sub.3                                                                            CH.sub.3 CH                                  CH    CH.sub.3                                                                               CH.sub.3                                                                               H     Cl    OCH.sub.3                                                                               CH                                  CH    CH.sub.3                                                                               CH.sub.3                                                                               H     CH.sub.3                                                                             CH.sub.3 CH                                  CH    CH.sub.3                                                                               CH.sub.3                                                                               H     OCH.sub.3                                                                            OCH.sub.3                                                                               N                                   CH    CH.sub.3                                                                               CH.sub.3                                                                               H     OCH.sub.3                                                                            CH.sub.3 N                                   CH    CH.sub.3                                                                               CH.sub.3                                                                               H     OC.sub.2 H.sub.5                                                                     NHCH.sub.3                                                                              N                                   CH    CH.sub.3                                                                               CH.sub.3                                                                               CH.sub.3                                                                             OCH.sub.3                                                                            CH.sub.3 N                                   N     CH.sub.3                                                                               CH.sub.3                                                                               H     OCH.sub.3                                                                            OCH.sub.3                                                                               CH                                  N     CH.sub.3                                                                               CH.sub.3                                                                               H     OCH.sub.3                                                                            CH.sub.3 CH                                  N     CH.sub.3                                                                               CH.sub.3                                                                               H     Cl    OCH.sub.3                                                                               CH                                  N     CH.sub.3                                                                               CH.sub.3                                                                               H     CH.sub.3                                                                             CH.sub.3 CH                                  N     CH.sub.3                                                                               CH.sub.3                                                                               H     OCH.sub.3                                                                            OCH.sub.3                                                                               N                                   N     CH.sub.3                                                                               CH.sub.3                                                                               H     OCH.sub.3                                                                            CH.sub.3 N                                   N     CH.sub.3                                                                               CH.sub.3                                                                               H     OC.sub.2 H.sub.5                                                                     NHCH.sub. 3                                                                             N                                   N     CH.sub.3                                                                               CH.sub.3                                                                               CH.sub.3                                                                             OCH.sub.3                                                                            CH.sub.3 N                                   CH    H       H       H     OCH.sub.3                                                                            OCH.sub.3                                                                               CH                                  CH    H       H       H     OCH.sub.3                                                                            CH.sub.3 CH                                  CH    H       H       H     Cl    OCH.sub.3                                                                               CH                                  CH    H       H       H     CH.sub.3                                                                             CH.sub.3 CH                                  CH    H       H       H     OCH.sub.3                                                                            OCH.sub.3                                                                               N                                   CH    H       H       H     OCH.sub.3                                                                            CH.sub.3 N                                   CH    H       H       H     OC.sub.2 H.sub.5                                                                     NHCH.sub.3                                                                              N                                   CH    H       H       CH.sub.3                                                                             OCH.sub.3                                                                            CH.sub.3 N                                   N     H       H       H     OCH.sub.3                                                                            OCH.sub.3                                                                               CH                                  N     H       H       H     OCH.sub.3                                                                            CH.sub.3 CH                                  N     H       H       H     Cl    OCH.sub.3                                                                               CH                                  N     H       H       H     CH.sub.3                                                                             CH.sub.3 CH                                  N     H       H       H     OCH.sub.3                                                                            OCH.sub.3                                                                               N                                   N     H       H       H     OCH.sub.3                                                                            CH.sub.3 N                                   N     H       H       H     OC.sub.2 H.sub.5                                                                     NHCH.sub.3                                                                              N                                   N     H       H       CH.sub.3                                                                             OCH.sub.3                                                                            CH.sub.3 N                                   ______________________________________                                    

                  TABLE 4b                                                         ______________________________________                                         General Formula 4b                                                             R.sup.2 R.sup.3 R        X     Y        Z.sup.4                                ______________________________________                                         CH.sub.3                                                                               CH.sub.3                                                                               H        OCH.sub.3                                                                            OCH.sub.3                                                                               CH                                     CH.sub.3                                                                               CH.sub.3                                                                               H        OCH.sub.3                                                                            CH.sub.3 CH                                     CH.sub.3                                                                               CH.sub.3                                                                               H        Cl    OCH.sub.3                                                                               CH                                     CH.sub.3                                                                               CH.sub.3                                                                               H        CH.sub.3                                                                             CH.sub.3 CH                                     CH.sub.3                                                                               CH.sub.3                                                                               H        OCH.sub.3                                                                            OCH.sub.3                                                                               N                                      CH.sub.3                                                                               CH.sub.3                                                                               H        OCH.sub.3                                                                            CH.sub.3 N                                      CH.sub.3                                                                               CH.sub.3                                                                               H        OC.sub.2 H.sub.5                                                                     NHCH.sub.3                                                                              N                                      CH.sub.3                                                                               CH.sub.3                                                                               CH.sub.3 OCH.sub.3                                                                            CH.sub.3 N                                      CH.sub.3                                                                               H       H        OCH.sub.3                                                                            OCH.sub.3                                                                               CH                                     CH.sub.3                                                                               H       H        OCH.sub.3                                                                            CH.sub.3 CH                                     CH.sub.3                                                                               H       H        Cl    OCH.sub.3                                                                               CH                                     CH.sub.3                                                                               H       H        CH.sub.3                                                                             CH.sub.3 CH                                     CH.sub.3                                                                               H       H        OCH.sub.3                                                                            OCH.sub.3                                                                               N                                      CH.sub.3                                                                               H       H        OCH.sub.3                                                                            CH.sub.3 N                                      CH.sub.3                                                                               H       H        OC.sub.2 H.sub.5                                                                     NHCH.sub.3                                                                              N                                      CH.sub.3                                                                               H       CH.sub.3 OCH.sub.3                                                                            CH.sub.3 N                                      H       CH.sub.3                                                                               H        OCH.sub.3                                                                            OCH.sub.3                                                                               CH                                     H       CH.sub.3                                                                               H        OCH.sub. 3                                                                           CH.sub.3 CH                                     H       CH.sub.3                                                                               H        Cl    OCH.sub.3                                                                               CH                                     H       CH.sub.3                                                                               H        CH.sub.3                                                                             CH.sub.3 CH                                     H       CH.sub.3                                                                               H        OCH.sub.3                                                                            OCH.sub.3                                                                               N                                      H       CH.sub.3                                                                               H        OCH.sub.3                                                                            CH.sub.3 N                                      H       CH.sub.3                                                                               H        OC.sub.2 H.sub.5                                                                     NHCH.sub.3                                                                              N                                      H       CH.sub.3                                                                               CH.sub.3 OCH.sub.3                                                                            CH.sub.3 N                                      H       H       H        OCH.sub.3                                                                            OCH.sub.3                                                                               CH                                     H       H       H        OCH.sub.3                                                                            CH.sub.3 CH                                     H       H       H        Cl    OCH.sub.3                                                                               CH                                     H       H       H        CH.sub.3                                                                             CH.sub.3 CH                                     H       H       H        OCH.sub.3                                                                            OCH.sub.3                                                                               N                                      H       H       H        OCH.sub.3                                                                            CH.sub.3 N                                      H       H       H        OC.sub.2 H.sub.5                                                                     NHCH.sub.3                                                                              N                                      H       H       CH.sub.3 OCH.sub.3                                                                            CH.sub.3 N                                      ______________________________________                                    

                                      TABLE 5                                      __________________________________________________________________________     General Formula 5                                                              Z.sup.1                                                                               R.sup.1     R.sup.2                                                                               R.sup.3                                                                               R      X        Y        Z.sup.4              __________________________________________________________________________     CH     H           CH.sub.3                                                                              CH.sub.3                                                                              H      OCH.sub.3                                                                               OCH.sub.3                                                                               CH                   CH     H           CH.sub.3                                                                              CH.sub.3                                                                              H      OCH.sub.3                                                                               CH.sub.3 CH                   CH     H           CH.sub.3                                                                              CH.sub.3                                                                              H      Cl       OCH.sub.3                                                                               CH                   CH     H           CH.sub.3                                                                              CH.sub.3                                                                              H      CH.sub.3 CH.sub.3 CH                   CH     H           CH.sub.3                                                                              CH.sub.3                                                                              H      OCH.sub.3                                                                               OCH.sub.3                                                                               N                    CH     H           CH.sub.3                                                                              CH.sub.3                                                                              H      OCH.sub.3                                                                               CH.sub.3 N                    CH     H           CH.sub.3                                                                              CH.sub.3                                                                              H      OC.sub.2 H.sub.5                                                                        NHCH.sub.3                                                                              N                    CH     H           CH.sub.3                                                                              CH.sub.3                                                                              CH.sub.3                                                                              OCH.sub.3                                                                               CH.sub.3 N                    CH     Cl          CH.sub.3                                                                              CH.sub.3                                                                              H      OCH.sub.3                                                                               OCH.sub.3                                                                               CH                   CH     Cl          CH.sub.3                                                                              CH.sub.3                                                                              H      OCH.sub.3                                                                               CH.sub.3 CH                   CH     Cl          CH.sub.3                                                                              CH.sub.3                                                                              H      Cl       OCH.sub.3                                                                               CH                   CH     Cl          CH.sub.3                                                                              CH.sub.3                                                                              H      CH.sub.3 CH.sub.3 CH                   CH     Cl          CH.sub.3                                                                              CH.sub.3                                                                              H      OCH.sub.3                                                                               OCH.sub.3                                                                               N                    CH     Cl          CH.sub.3                                                                              CH.sub. 3                                                                             H      OCH.sub.3                                                                               CH.sub.3 N                    CH     Cl          CH.sub.3                                                                              CH.sub.3                                                                              H      OC.sub.2 H.sub.5                                                                        NHCH.sub.3                                                                              N                    CH     Cl          CH.sub.3                                                                              CH.sub.3                                                                              CH.sub.3                                                                              OCH.sub.3                                                                               CH.sub.3 N                    CH     SO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                              CH.sub.3                                                                              H      OCH.sub.3                                                                               OCH.sub.3                                                                               CH                   CH     SO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                              CH.sub.3                                                                              H      OCH.sub.3                                                                               CH.sub.3 CH                   CH     SO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                              CH.sub.3                                                                              H      Cl       OCH.sub.3                                                                               CH                   CH     SO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                              CH.sub.3                                                                              H      CH.sub.3 CH.sub.3 CH                   CH     SO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                              CH.sub.3                                                                              H      OCH.sub.3                                                                               OCH.sub.3                                                                               N                    CH     SO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                              CH.sub.3                                                                              H      OCH.sub.3                                                                               CH.sub.3 N                    CH     SO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                              CH.sub.3                                                                              H      OC.sub.2 H.sub.5                                                                        NHCH.sub.3                                                                              N                    CH     SO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                              CH.sub.3                                                                              CH.sub.3                                                                              OCH.sub.3                                                                               CH.sub.3 N                    CH     SO.sub.2 N(CH.sub.3).sub.2                                                                 CH.sub.3                                                                              CH.sub.3                                                                              H      OCH.sub.3                                                                               OCH.sub.3                                                                               CH                   CH     SO.sub.2 N(CH.sub.3).sub.2                                                                 CH.sub.3                                                                              CH.sub.3                                                                              H      OCH.sub.3                                                                               CH.sub.3 CH                   CH     SO.sub.2 N(CH.sub.3).sub.2                                                                 CH.sub.3                                                                              CH.sub. 3                                                                             H      Cl       OCH.sub.3                                                                               CH                   CH     SO.sub.2 N(CH.sub.3).sub.2                                                                 CH.sub.3                                                                              CH.sub.3                                                                              H      OCH.sub.3                                                                               OCH.sub.3                                                                               N                    CH     SO.sub.2 N(CH.sub.3).sub.2                                                                 CH.sub.3                                                                              CH.sub.3                                                                              H      OCH.sub.3                                                                               CH.sub.3 N                    CH     H           H      H      H      OCH.sub.3                                                                               OCH.sub.3                                                                               CH                   CH     H           H      H      H      OCH.sub.3                                                                               CH.sub.3 CH                   CH     H           H      H      H      Cl       OCH.sub.3                                                                               CH                   CH     H           H      H      H      CH.sub.3 CH.sub.3 CH                   CH     H           H      H      H      OCH.sub.3                                                                               OCH.sub.3                                                                               N                    CH     H           H      H      H      OCH.sub.3                                                                               CH.sub.3 N                    CH     H           H      H      H      OC.sub.2 H.sub.5                                                                        NHCH.sub.3                                                                              N                    CH     H           H      H      CH.sub.3                                                                              OCH.sub.3                                                                               CH.sub.3 N                    CH     Cl          H      H      H      OCH.sub.3                                                                               OCH.sub.3                                                                               CH                   CH     Cl          H      H      H      OCH.sub.3                                                                               CH.sub.3 CH                   CH     Cl          H      H      H      Cl       OCH.sub.3                                                                               CH                   CH     Cl          H      H      H      CH.sub.3 CH.sub.3 CH                   CH     Cl          H      H      H      OCH.sub.3                                                                               OCH.sub.3                                                                               N                    CH     Cl          H      H      H      OCH.sub.3                                                                               CH.sub.3 N                    CH     Cl          H      H      H      OC.sub.2 H.sub.5                                                                        NHCH.sub.3                                                                              N                    CH     Cl          H      H      CH.sub.3                                                                              OCH.sub. 3                                                                              CH.sub.3 N                    CH     SO.sub.2 CH.sub.3                                                                          H      H      H      OCH.sub.3                                                                               OCH.sub.3                                                                               CH                   CH     SO.sub.2 CH.sub.3                                                                          H      H      H      OCH.sub.3                                                                               CH.sub.3 CH                   CH     SO.sub.2 CH.sub.3                                                                          H      H      H      Cl       OCH.sub.3                                                                               CH                   CH     SO.sub.2 CH.sub.3                                                                          H      H      H      CH.sub.3 CH.sub.3 CH                   CH     SO.sub.2 CH.sub.3                                                                          H      H      H      OCH.sub.3                                                                               OCH.sub.3                                                                               N                    CH     SO.sub.2 CH.sub.3                                                                          H      H      H      OCH.sub.3                                                                               CH.sub.3 N                    CH     SO.sub.2 CH.sub.3                                                                          H      H      H      OC.sub.2 H.sub.5                                                                        NHCH.sub.3                                                                              N                    CH     SO.sub.2 CH.sub.3                                                                          H      H      CH.sub.3                                                                              OCH.sub.3                                                                               CH.sub.3 N                    CH     SO.sub.2 N(CH.sub.3).sub.2                                                                 H      H      H      OCH.sub.3                                                                               OCH.sub.3                                                                               CH                   CH     SO.sub.2 N(CH.sub.3).sub.2                                                                 H      H      H      OCH.sub.3                                                                               CH.sub.3 CH                   CH     SO.sub.2 N(CH.sub.3).sub.2                                                                 H      H      H      Cl       OCH.sub.3                                                                               CH                   CH     SO.sub.2 N(CH.sub.3).sub.2                                                                 H      H      H      OCH.sub.3                                                                               OCH.sub.3                                                                               N                    CH     SO.sub.2 N(CH.sub.3).sub.2                                                                 H      H      H      OCH.sub.3                                                                               CH.sub.3 N                    CH     H           H      CH.sub.3                                                                              H      OCH.sub.3                                                                               OCH.sub.3                                                                               CH                   CH     H           H      CH.sub.3                                                                              H      OCH.sub.3                                                                               CH.sub.3 CH                   CH     H           H      CH.sub.3                                                                              H      Cl       OCH.sub.3                                                                               CH                   CH     H           H      CH.sub.3                                                                              H      CH.sub.3 CH.sub.3 CH                   CH     H           H      CH.sub.3                                                                              H      OCH.sub.3                                                                               OCH.sub.3                                                                               N                    CH     H           H      CH.sub.3                                                                              H      OCH.sub.3                                                                               CH.sub.3 N                    CH     H           H      CH.sub.3                                                                              H      OC.sub.2 H.sub.5                                                                        NHCH.sub.3                                                                              N                    CH     H           H      CH.sub.3                                                                              CH.sub.3                                                                              OCH.sub.3                                                                               CH.sub.3 N                    CH     Cl          H      CH.sub.3                                                                              H      OCH.sub.3                                                                               OCH.sub.3                                                                               CH                   CH     Cl          H      CH.sub.3                                                                              H      OCH.sub.3                                                                               CH.sub.3 CH                   CH     Cl          H      CH.sub.3                                                                              H      Cl       OCH.sub.3                                                                               CH                   CH     Cl          H      CH.sub.3                                                                              H      CH.sub.3 CH.sub.3 CH                   CH     Cl          H      CH.sub.3                                                                              H      OCH.sub.3                                                                               OCH.sub.3                                                                               N                    CH     Cl          H      CH.sub.3                                                                              H      OCH.sub.3                                                                               CH.sub.3 N                    CH     Cl          H      CH.sub.3                                                                              H      OC.sub.2 H.sub.5                                                                        NHCH.sub.3                                                                              N                    CH     Cl          H      CH.sub.3                                                                              CH.sub.3                                                                              OCH.sub.3                                                                               CH.sub.3 N                    CH     SO.sub.2 CH.sub.3                                                                          H      CH.sub.3                                                                              H      OCH.sub.3                                                                               OCH.sub.3                                                                               CH                   CH     SO.sub.2 CH.sub.3                                                                          H      CH.sub.3                                                                              H      OCH.sub.3                                                                               CH.sub.3 CH                   CH     SO.sub.2 CH.sub.3                                                                          H      CH.sub.3                                                                              H      Cl       OCH.sub.3                                                                               CH                   CH     SO.sub.2 CH.sub.3                                                                          H      CH.sub.3                                                                              H      CH.sub.3 CH.sub.3 CH                   CH     SO.sub.2 CH.sub.3                                                                          H      CH.sub.3                                                                              H      OCH.sub.3                                                                               OCH.sub.3                                                                               N                    CH     SO.sub.2 CH.sub.3                                                                          H      CH.sub.3                                                                              H      OCH.sub.3                                                                               CH.sub.3 N                    CH     SO.sub.2 CH.sub.3                                                                          H      CH.sub.3                                                                              H      OC.sub.2 H.sub.5                                                                        NHCH.sub.3                                                                              N                    CH     SO.sub.2 CH.sub.3                                                                          H      CH.sub.3                                                                              CH.sub.3                                                                              OCH.sub.3                                                                               CH.sub.3 N                    CH     SO.sub.2 N(CH.sub.3).sub.2                                                                 H      CH.sub.3                                                                              H      OCH.sub.3                                                                               OCH.sub.3                                                                               CH                   CH     SO.sub.2 N(CH.sub.3).sub.2                                                                 H      CH.sub.3                                                                              H      OCH.sub.3                                                                               CH.sub.3 CH                   CH     SO.sub.2 N(CH.sub.3).sub.2                                                                 H      CH.sub.3                                                                              H      Cl       OCH.sub.3                                                                               CH                   CH     SO.sub.2 N(CH.sub.3).sub.2                                                                 H      CH.sub.3                                                                              H      OCH.sub.3                                                                               OCH.sub.3                                                                               N                    CH     SO.sub.2 N(CH.sub.3).sub.2                                                                 H      CH.sub.3                                                                              H      OCH.sub.3                                                                               CH.sub.3 N                    CH     H           CH.sub.3                                                                              H      H      OCH.sub.3                                                                               OCH.sub.3                                                                               CH                   CH     H           CH.sub.3                                                                              H      H      OCH.sub.3                                                                               CH.sub.3 CH                   CH     H           CH.sub.3                                                                              H      H      Cl       OCH.sub.3                                                                               CH                   CH     H           CH.sub.3                                                                              H      H      CH.sub.3 CH.sub.3 CH                   CH     H           CH.sub.3                                                                              H      H      OCH.sub.3                                                                               OCH.sub.3                                                                               N                    CH     H           CH.sub.3                                                                              H      H      OCH.sub.3                                                                               CH.sub.3 N                    CH     H           CH.sub.3                                                                              H      H      OC.sub.2 H.sub.5                                                                        NHCH.sub.3                                                                              N                    CH     H           CH.sub.3                                                                              H      CH.sub.3                                                                              OCH.sub.3                                                                               CH.sub.3 N                    CH     Cl          CH.sub.3                                                                              H      H      OCH.sub.3                                                                               OCH.sub.3                                                                               CH                   CH     Cl          CH.sub.3                                                                              H      H      OCH.sub.3                                                                               CH.sub.3 CH                   CH     Cl          CH.sub.3                                                                              H      H      Cl       OCH.sub.3                                                                               CH                   CH     Cl          CH.sub.3                                                                              H      H      CH.sub.3 CH.sub.3 CH                   CH     Cl          CH.sub.3                                                                              H      H      OCH.sub.3                                                                               OCH.sub.3                                                                               N                    CH     Cl          CH.sub.3                                                                              H      H      OCH.sub.3                                                                               CH.sub.3 N                    CH     Cl          CH.sub.3                                                                              H      H      OC.sub.2 H.sub.5                                                                        NHCH.sub.3                                                                              N                    CH     Cl          CH.sub.3                                                                              H      CH.sub.3                                                                              OCH.sub.3                                                                               CH.sub.3 N                    CH     SO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                              H      H      OCH.sub.3                                                                               OCH.sub.3                                                                               CH                   CH     SO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                              H      H      OCH.sub.3                                                                               CH.sub.3 CH                   CH     SO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                              H      H      Cl       OCH.sub.3                                                                               CH                   CH     SO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                              H      H      CH.sub.3 CH.sub.3 CH                   CH     SO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                              H      H      OCH.sub.3                                                                               OCH.sub.3                                                                               N                    CH     SO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                              H      H      OCH.sub.3                                                                               CH.sub.3 N                    CH     SO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                              H      H      OC.sub.2 H.sub.5                                                                        NHCH.sub.3                                                                              N                    CH     SO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                              H      CH.sub.3                                                                              OCH.sub.3                                                                               CH.sub.3 N                    CH     SO.sub.2 N(CH.sub.3).sub.2                                                                 CH.sub.3                                                                              H      H      OCH.sub.3                                                                               OCH.sub.3                                                                               CH                   CH     SO.sub.2 N(CH.sub.3).sub.2                                                                 CH.sub.3                                                                              H      H      OCH.sub.3                                                                               CH.sub.3 CH                   CH     SO.sub.2 N(CH.sub.3).sub.2                                                                 CH.sub.3                                                                              H      H      Cl       OCH.sub.3                                                                               CH                   CH     SO.sub.2 N(CH.sub.3).sub.2                                                                 CH.sub.3                                                                              H      H      OCH.sub.3                                                                               OCH.sub.3                                                                               N                    CH     SO.sub.2 N(CH.sub.3).sub.2                                                                 CH.sub.3                                                                              H      H      OCH.sub.3                                                                               CH.sub.3 N                    N      H           CH.sub.3                                                                              CH.sub.3                                                                              H      OCH.sub.3                                                                               OCH.sub.3                                                                               CH                   N      H           CH.sub.3                                                                              CH.sub.3                                                                              H      OCH.sub.3                                                                               CH.sub.3 CH                   N      H           CH.sub.3                                                                              CH.sub.3                                                                              H      Cl       OCH.sub.3                                                                               CH                   N      H           CH.sub.3                                                                              CH.sub.3                                                                              H      CH.sub.3 CH.sub.3 CH                   N      H           CH.sub.3                                                                              CH.sub.3                                                                              H      OCH.sub.3                                                                               OCH.sub.3                                                                               N                    N      H           CH.sub.3                                                                              CH.sub.3                                                                              H      OCH.sub.3                                                                               CH.sub.3 N                    N      H           CH.sub.3                                                                              CH.sub.3                                                                              H      OC.sub.2 H.sub.5                                                                        NHCH.sub.3                                                                              N                    N      H           CH.sub.3                                                                              CH.sub.3                                                                              CH.sub.3                                                                              OCH.sub.3                                                                               CH.sub.3 N                    N      Cl          CH.sub.3                                                                              CH.sub.3                                                                              H      OCH.sub.3                                                                               OCH.sub.3                                                                               CH                   N      Cl          CH.sub.3                                                                              CH.sub.3                                                                              H      OCH.sub.3                                                                               CH.sub.3 CH                   N      Cl          CH.sub.3                                                                              CH.sub.3                                                                              H      Cl       OCH.sub.3                                                                               CH                   N      Cl          CH.sub.3                                                                              CH.sub.3                                                                              H      CH.sub.3 CH.sub.3 CH                   N      Cl          CH.sub.3                                                                              CH.sub.3                                                                              H      OCH.sub.3                                                                               OCH.sub.3                                                                               N                    N      Cl          CH.sub.3                                                                              CH.sub.3                                                                              H      OCH.sub.3                                                                               CH.sub.3 N                    N      Cl          CH.sub.3                                                                              CH.sub.3                                                                              H      OC.sub.2 H.sub.5                                                                        NHCH.sub.3                                                                              N                    N      Cl          CH.sub.3                                                                              CH.sub.3                                                                              CH.sub.3                                                                              OCH.sub.3                                                                               CH.sub.3 N                    N      SO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                              CH.sub.3                                                                              H      OCH.sub.3                                                                               OCH.sub.3                                                                               CH                   N      SO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                              CH.sub.3                                                                              H      OCH.sub.3                                                                               CH.sub.3 CH                   N      SO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                              CH.sub.3                                                                              H      Cl       OCH.sub.3                                                                               CH                   N      SO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                              CH.sub.3                                                                              H      CH.sub.3 CH.sub.3 CH                   N      SO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                              CH.sub.3                                                                              H      OCH.sub.3                                                                               OCH.sub.3                                                                               N                    N      SO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                              CH.sub.3                                                                              H      OCH.sub.3                                                                               CH.sub.3 N                    N      SO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                              CH.sub.3                                                                              H      OC.sub.2 H.sub.5                                                                        NHCH.sub.3                                                                              N                    N      SO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                              CH.sub.3                                                                              CH.sub.3                                                                              OCH.sub.3                                                                               CH.sub.3 N                    N      SO.sub.2 N(CH.sub.3).sub.2                                                                 CH.sub.3                                                                              CH.sub.3                                                                              H      OCH.sub.3                                                                               OCH.sub.3                                                                               CH                   N      SO.sub.2 N(CH.sub.3).sub.2                                                                 CH.sub.3                                                                              CH.sub.3                                                                              H      OCH.sub.3                                                                               CH.sub.3 CH                   N      SO.sub.2 N(CH.sub.3).sub.2                                                                 CH.sub.3                                                                              CH.sub.3                                                                              H      Cl       OCH.sub.3                                                                               CH                   N      SO.sub.2 N(CH.sub.3).sub.2                                                                 CH.sub.3                                                                              CH.sub.3                                                                              H      OCH.sub.3                                                                               OCH.sub.3                                                                               N                    N      SO.sub.2 N(CH.sub.3).sub.2                                                                 CH.sub.3                                                                              CH.sub.3                                                                              H      OCH.sub.3                                                                               CH.sub.3 N                    N      H           H      H      H      OCH.sub.3                                                                               OCH.sub.3                                                                               CH                   N      H           H      H      H      OCH.sub.3                                                                               CH.sub.3 CH                   N      H           H      H      H      Cl       OCH.sub.3                                                                               CH                   N      H           H      H      H      CH.sub.3 CH.sub.3 CH                   N      H           H      H      H      OCH.sub.3                                                                               OCH.sub.3                                                                               N                    N      H           H      H      H      OCH.sub.3                                                                               CH.sub.3 N                    N      H           H      H      H      OC.sub.2 H.sub.5                                                                        NHCH.sub.3                                                                              N                    N      H           H      H      CH.sub.3                                                                              OCH.sub.3                                                                               CH.sub.3 N                    N      Cl          H      H      H      OCH.sub.3                                                                               OCH.sub.3                                                                               CH                   N      Cl          H      H      H      OCH.sub.3                                                                               CH.sub.3 CH                   N      Cl          H      H      H      Cl       OCH.sub.3                                                                               CH                   N      Cl          H      H      H      CH.sub.3 CH.sub.3 CH                   N      Cl          H      H      H      OCH.sub.3                                                                               OCH.sub.3                                                                               N                    N      Cl          H      H      H      OCH.sub.3                                                                               CH.sub.3 N                    N      Cl          H      H      H      OC.sub.2 H.sub.5                                                                        NHCH.sub.3                                                                              N                    N      Cl          H      H      CH.sub.3                                                                              OCH.sub.3                                                                               CH.sub.3 N                    N      SO.sub.2 CH.sub.3                                                                          H      H      H      OCH.sub.3                                                                               OCH.sub.3                                                                               CH                   N      SO.sub.2 CH.sub.3                                                                          H      H      H      OCH.sub.3                                                                               CH.sub.3 CH                   N      SO.sub.2 CH.sub.3                                                                          H      H      H      Cl       OCH.sub.3                                                                               CH                   N      SO.sub.2 CH.sub.3                                                                          H      H      H      CH.sub.3 CH.sub.3 CH                   N      SO.sub.2 CH.sub.3                                                                          H      H      H      OCH.sub.3                                                                               OCH.sub.3                                                                               N                    N      SO.sub.2 CH.sub.3                                                                          H      H      H      OCH.sub.3                                                                               CH.sub.3 N                    N      SO.sub.2 CH.sub.3                                                                          H      H      H      OC.sub.2 H.sub.5                                                                        NHCH.sub.3                                                                              N                    N      SO.sub.2 CH.sub.3                                                                          H      H      CH.sub.3                                                                              OCH.sub.3                                                                               CH.sub.                                                                                 N                    N      SO.sub.2 N(CH.sub.3).sub.2                                                                 H      H      H      OCH.sub.3                                                                               OCH.sub.3                                                                               CH                   N      SO.sub.2 N(CH.sub.3).sub.2                                                                 H      H      H      OCH.sub.3                                                                               CH.sub.3 CH                   N      SO.sub.2 N(CH.sub.3).sub.2                                                                 H      H      H      Cl       OCH.sub.3                                                                               CH                   N      SO.sub.2 N(CH.sub.3).sub.2                                                                 H      H      H      OCH.sub.3                                                                               OCH.sub.3                                                                               N                    N      SO.sub.2 N(CH.sub.3).sub.2                                                                 H      H      H      OCH.sub.3                                                                               CH.sub.3 N                    N      H           H      CH.sub.3                                                                              H      OCH.sub.3                                                                               OCH.sub.3                                                                               CH                   N      H           H      CH.sub.3                                                                              H      OCH.sub.3                                                                               CH.sub.3 CH                   N      H           H      CH.sub.3                                                                              H      Cl       OCH.sub.3                                                                               CH                   N      H           H      CH.sub.3                                                                              H      CH.sub.3 CH.sub.3 CH                   N      H           H      CH.sub.3                                                                              H      OCH.sub.3                                                                               OCH.sub.3                                                                               N                    N      H           H      CH.sub.3                                                                              H      OCH.sub.3                                                                               CH.sub.3 N                    N      H           H      CH.sub.3                                                                              H      OC.sub.2 H.sub.5                                                                        NHCH.sub.3                                                                              N                    N      H           H      CH.sub.3                                                                              CH.sub.3                                                                              OCH.sub.3                                                                               CH.sub.3 N                    N      Cl          H      CH.sub.3                                                                              H      OCH.sub.3                                                                               OCH.sub.3                                                                               CH                   N      Cl          H      CH.sub.3                                                                              H      OCH.sub.3                                                                               CH.sub.3 CH                   N      Cl          H      CH.sub.3                                                                              H      Cl       OCH.sub.3                                                                               CH                   N      Cl          H      CH.sub.3                                                                              H      CH.sub.3 CH.sub.3 CH                   N      Cl          H      CH.sub.3                                                                              H      OCH.sub.3                                                                               OCH.sub.3                                                                               N                    N      Cl          H      CH.sub.3                                                                              H      OCH.sub.3                                                                               CH.sub.3 N                    N      Cl          H      CH.sub.3                                                                              H      OC.sub.2 H.sub.5                                                                        NHCH.sub.3                                                                              N                    N      Cl          H      CH.sub.3                                                                              CH.sub.3                                                                              OCH.sub.3                                                                               CH.sub.3 N                    N      SO.sub.2 CH.sub.3                                                                          H      CH.sub.3                                                                              H      OCH.sub.3                                                                               OCH.sub.3                                                                               CH                   N      SO.sub.2 CH.sub.3                                                                          H      CH.sub.3                                                                              H      OCH.sub.3                                                                               CH.sub.3 CH                   N      SO.sub.2 CH.sub.3                                                                          H      CH.sub.3                                                                              H      Cl       OCH.sub.3                                                                               CH                   N      SO.sub.2 CH.sub.3                                                                          H      CH.sub.3                                                                              H      CH.sub.3 CH.sub.3 CH                   N      SO.sub.2 CH.sub.3                                                                          H      CH.sub.3                                                                              H      OCH.sub.3                                                                               OCH.sub.3                                                                               N                    N      SO.sub.2 CH.sub.3                                                                          H      CH.sub.3                                                                              H      OCH.sub.3                                                                               CH.sub.3 N                    N      SO.sub.2 CH.sub.3                                                                          H      CH.sub.3                                                                              H      OC.sub.2 H.sub.5                                                                        NHCH.sub.3                                                                              N                    N      SO.sub.2 CH.sub.3                                                                          H      CH.sub.3                                                                              CH.sub.3                                                                              OCH.sub.3                                                                               CH.sub.3 N                    N      SO.sub.2 N(CH.sub.3).sub.2                                                                 H      CH.sub.3                                                                              H      OCH.sub.3                                                                               OCH.sub.3                                                                               CH                   N      SO.sub.2 N(CH.sub.3).sub.2                                                                 H      CH.sub.3                                                                              H      OCH.sub.3                                                                               CH.sub.                                                                                 CH                   N      SO.sub.2 N(CH.sub.3).sub.2                                                                 H      CH.sub.3                                                                              H      Cl       OCH.sub.3                                                                               CH                   N      SO.sub.2 N(CH.sub.3).sub.2                                                                 H      CH.sub.3                                                                              H      OCH.sub.3                                                                               OCH.sub.3                                                                               N                    N      SO.sub.2 N(CH.sub.3).sub.2                                                                 H      CH.sub.3                                                                              H      OCH.sub.3                                                                               CH.sub.3 N                    N      H           CH.sub.3                                                                              H      H      OCH.sub.3                                                                               OCH.sub.3                                                                               CH                   N      H           CH.sub.3                                                                              H      H      OCH.sub.3                                                                               CH.sub.3 CH                   N      H           CH.sub.3                                                                              H      H      Cl       OCH.sub.3                                                                               CH                   N      H           CH.sub.3                                                                              H      H      CH.sub.3 CH.sub.3 CH                   N      H           CH.sub.3                                                                              H      H      OCH.sub.3                                                                               OCH.sub.3                                                                               N                    N      H           CH.sub.3                                                                              H      H      OCH.sub.3                                                                               CH.sub.3 N                    N      H           CH.sub.3                                                                              H      H      OC.sub.2 H.sub.5                                                                        NHCH.sub.3                                                                              N                    N      H           CH.sub.3                                                                              H      CH.sub.3                                                                              OCH.sub.3                                                                               CH.sub.3 N                    N      Cl          CH.sub.3                                                                              H      H      OCH.sub.3                                                                               OCH.sub.3                                                                               CH                   N      Cl          CH.sub.3                                                                              H      H      OCH.sub.3                                                                               CH.sub.3 CH                   N      Cl          CH.sub.3                                                                              H      H      Cl       OCH.sub.3                                                                               CH                   N      Cl          CH.sub.3                                                                              H      H      CH.sub.3 CH.sub.3 CH                   N      Cl          CH.sub.3                                                                              H      H      OCH.sub.3                                                                               OCH.sub.3                                                                               N                    N      Cl          CH.sub.3                                                                              H      H      OCH.sub. 3                                                                              CH.sub.3 N                    N      Cl          CH.sub.3                                                                              H      H      OC.sub.2 H.sub.5                                                                        NHCH.sub.3                                                                              N                    N      Cl          CH.sub.3                                                                              H      CH.sub.3                                                                              OCH.sub.3                                                                               CH.sub.3 N                    N      SO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                              H      H      OCH.sub.3                                                                               OCH.sub.3                                                                               CH                   N      SO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                              H      H      OCH.sub.3                                                                               CH.sub.3 CH                   N      SO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                              H      H      Cl       OCH.sub.3                                                                               CH                   N      SO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                              H      H      CH.sub.3 CH.sub.3 CH                   N      SO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                              H      H      OCH.sub.3                                                                               OCH.sub.3                                                                               N                    N      SO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                              H      H      OCH.sub.3                                                                               CH.sub.3 N                    N      SO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                              H      H      OC.sub.2 H.sub.5                                                                        NHCH.sub.3                                                                              N                    N      SO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                              H      CH.sub.3                                                                              OCH.sub.3                                                                               CH.sub.3 N                    N      SO.sub.2 N(CH.sub.3).sub.2                                                                 CH.sub.3                                                                              H      H      OCH.sub.3                                                                               OCH.sub.3                                                                               CH                   N      SO.sub.2 N(CH.sub.3).sub.2                                                                 CH.sub.3                                                                              H      H      OCH.sub.3                                                                               CH.sub.3 CH                   N      SO.sub.2 N(CH.sub.3).sub.2                                                                 CH.sub.3                                                                              H      H      Cl       OCH.sub.3                                                                               CH                   N      SO.sub.2 N(CH.sub.3).sub.2                                                                 CH.sub.3                                                                              H      H      OCH.sub.3                                                                               OCH.sub.3                                                                               N                    N      SO.sub.2 N(CH.sub.3).sub.2                                                                 CH.sub.3                                                                              H      H      OCH.sub.3                                                                               CH.sub.3 N                    CH     CO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                              CH.sub.3                                                                              H      OCH.sub.3                                                                               OCH.sub.3                                                                               CH                   CH     CO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                              CH.sub.3                                                                              H      OCH.sub.3                                                                               CH.sub.3 CH                   CH     CO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                              CH.sub.3                                                                              H      Cl       OCH.sub.3                                                                               CH                   CH     CO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                              CH.sub.3                                                                              H      CH.sub.3 CH.sub.3 CH                   CH     CO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                              CH.sub.3                                                                              H      OCH.sub.3                                                                               OCH.sub.3                                                                               N                    CH     CO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                              CH.sub.3                                                                              H      OCH.sub.3                                                                               CH.sub.3 N                    CH     CO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                              CH.sub.3                                                                              H      OC.sub.2 H.sub.5                                                                        NHCH.sub.3                                                                              N                    CH     CO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                              CH.sub.3                                                                              CH.sub.3                                                                              OCH.sub.3                                                                               CH.sub.3 N                    CH     CO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                              H      H      OCH.sub.3                                                                               OCH.sub.3                                                                               CH                   CH     CO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                              H      H      OCH.sub.3                                                                               CH.sub.3 CH                   CH     CO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                              H      H      Cl       OCH.sub.3                                                                               CH                   CH     CO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                              H      H      CH.sub.3 CH.sub.3 CH                   CH     CO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                              H      H      OCH.sub.3                                                                               OCH.sub.3                                                                               N                    CH     CO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                              H      H      OCH.sub.3                                                                               CH.sub.3 N                    CH     CO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                              H      H      OC.sub.2 H.sub.5                                                                        NHCH.sub.3                                                                              N                    CH     CO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                              H      CH.sub.3                                                                              OCH.sub.3                                                                               CH.sub.3 N                    CH     CO.sub.2 CH.sub.3                                                                          H      CH.sub.3                                                                              H      OCH.sub.3                                                                               OCH.sub.3                                                                               CH                   CH     CO.sub.2 CH.sub.3                                                                          H      CH.sub.3                                                                              H      OCH.sub.3                                                                               CH.sub.3 CH                   CH     CO.sub.2 CH.sub.3                                                                          H      CH.sub.3                                                                              H      Cl       OCH.sub.3                                                                               CH                   CH     CO.sub.2 CH.sub.3                                                                          H      CH.sub.3                                                                              H      CH.sub.3 CH.sub.3 CH                   CH     CO.sub.2 CH.sub.3                                                                          H      CH.sub.3                                                                              H      OCH.sub.3                                                                               OCH.sub.3                                                                               N                    CH     CO.sub.2 CH.sub.3                                                                          H      CH.sub.3                                                                              H      OCH.sub.3                                                                               CH.sub.3 N                    CH     CO.sub.2 CH.sub.3                                                                          H      CH.sub.3                                                                              H      OC.sub.2 H.sub.5                                                                        NHCH.sub.3                                                                              N                    CH     CO.sub.2 CH.sub.3                                                                          H      CH.sub.3                                                                              CH.sub.3                                                                              OCH.sub.3                                                                               CH.sub.3 N                    CH     CO.sub.2 CH.sub.3                                                                          H      H      H      OCH.sub.3                                                                               OCH.sub.3                                                                               CH                   CH     CO.sub.2 CH.sub.3                                                                          H      H      H      OCH.sub.3                                                                               CH.sub.3 CH                   CH     CO.sub. 2 CH.sub.3                                                                         H      H      H      Cl       OCH.sub.3                                                                               CH                   CH     CO.sub.2 CH.sub.3                                                                          H      H      H      CH.sub.3 CH.sub.3 CH                   CH     CO.sub.2 CH.sub.3                                                                          H      H      H      OCH.sub.3                                                                               OCH.sub.3                                                                               N                    CH     CO.sub.2 CH.sub.3                                                                          H      H      H      OCH.sub.3                                                                               CH.sub.3 N                    CH     CO.sub.2 CH.sub.3                                                                          H      H      H      OC.sub.2 H.sub.5                                                                        NHCH.sub.3                                                                              N                    CH     CO.sub.2 CH.sub.3                                                                          H      H      CH.sub.3                                                                              OCH.sub.3                                                                               CH.sub.3 N                    CH     CO.sub.2 C.sub.2 H.sub.5                                                                   H      H      H      OCH.sub.3                                                                               OCH.sub.3                                                                               CH                   CH     CO.sub.2 C.sub.2 H.sub.5                                                                   H      H      H      OCH.sub.3                                                                               CH.sub.3 CH                   CH     CO.sub.2 C.sub.2 H.sub.5                                                                   H      H      H      Cl       OCH.sub.3                                                                               CH                   CH     CO.sub.2 C.sub.2 H.sub.5                                                                   H      H      H      CH.sub.3 CH.sub.3 CH                   CH     CO.sub.2 C.sub.2 H.sub.5                                                                   H      H      H      OCH.sub.3                                                                               OCH.sub.3                                                                               N                    CH     CO.sub.2 C.sub.2 H.sub.5                                                                   H      H      H      OCH.sub.3                                                                               CH.sub.3 N                    CH     CO.sub.2 C.sub.2 H.sub.5                                                                   H      H      H      OC.sub.2 H.sub.5                                                                        NHCH.sub.3                                                                              N                    CH     CO.sub.2 C.sub.2 H.sub.5                                                                   H      H      CH.sub.3                                                                              OCH.sub.3                                                                               CH.sub.3 N                    CH     CO.sub.2 C.sub.2 H.sub.5                                                                   CH.sub.3                                                                              CH.sub.3                                                                              H      OCH.sub.3                                                                               OCH.sub.3                                                                               CH                   CH     CO.sub.2 C.sub.2 H.sub.5                                                                   CH.sub.3                                                                              CH.sub.3                                                                              H      OCH.sub.3                                                                               CH.sub.3 CH                   CH     CO.sub.2 C.sub.2 H.sub.5                                                                   CH.sub.3                                                                              CH.sub.3                                                                              H      Cl       OCH.sub.3                                                                               CH                   CH     CO.sub.2 C.sub.2 H.sub.5                                                                   CH.sub.3                                                                              CH.sub.3                                                                              H      CH.sub.3 CH.sub.3 CH                   CH     CO.sub.2 C.sub.2 H.sub.5                                                                   CH.sub.3                                                                              CH.sub.3                                                                              H      OCH.sub.3                                                                               OCH.sub.3                                                                               N                    CH     CO.sub.2 C.sub.2 H.sub.5                                                                   CH.sub.3                                                                              CH.sub.3                                                                              H      OCH.sub.3                                                                               CH.sub.3 N                    CH     CO.sub.2 C.sub.2 H.sub.5                                                                   CH.sub.3                                                                              CH.sub.3                                                                              H      OC.sub.2 H.sub.5                                                                        NHCH.sub.3                                                                              N                    CH     CO.sub.2 C.sub.2 H.sub.5                                                                   CH.sub.3                                                                              CH.sub.3                                                                              CH.sub.3                                                                              OCH.sub.3                                                                               CH.sub.3 N                    N      CO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                              CH.sub.3                                                                              H      OCH.sub.3                                                                               OCH.sub.3                                                                               CH                   N      CO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                              CH.sub.3                                                                              H      OCH.sub.3                                                                               CH.sub.3 CH                   N      CO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                              CH.sub.3                                                                              H      Cl       OCH.sub.3                                                                               CH                   N      CO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                              CH.sub.3                                                                              H      CH.sub.3 CH.sub.3 CH                   N      CO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                              CH.sub.3                                                                              H      OCH.sub.3                                                                               OCH.sub.3                                                                               N                    N      CO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                              CH.sub.3                                                                              H      OCH.sub.3                                                                               CH.sub.3 N                    N      CO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                              CH.sub.3                                                                              H      OC.sub.2 H.sub.5                                                                        NHCH.sub.3                                                                              N                    N      CO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                              CH.sub.3                                                                              CH.sub.3                                                                              OCH.sub.3                                                                               CH.sub.3 N                    N      CO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                              H      H      OCH.sub.3                                                                               OCH.sub.3                                                                               CH                   N      CO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                              H      H      OCH.sub.3                                                                               CH.sub.3 CH                   N      CO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                              H      H      Cl       OCH.sub.3                                                                               CH                   N      CO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                              H      H      CH.sub.3 CH.sub.3 CH                   N      CO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                              H      H      OCH.sub.3                                                                               OCH.sub.3                                                                               N                    N      CO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                              H      H      OCH.sub.3                                                                               CH.sub.3 N                    N      CO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                              H      H      OC.sub.2 H.sub.5                                                                        NHCH.sub.3                                                                              N                    N      CO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                              H      CH.sub.3                                                                              OCH.sub.3                                                                               CH.sub.3 N                    N      CO.sub.2 CH.sub.3                                                                          H      CH.sub.3                                                                              H      OCH.sub.3                                                                               OCH.sub.3                                                                               CH                   N      CO.sub.2 CH.sub.3                                                                          H      CH.sub.3                                                                              H      OCH.sub.3                                                                               CH.sub.                                                                                 CH                   N      CO.sub.2 CH.sub.3                                                                          H      CH.sub.3                                                                              H      Cl       OCH.sub.3                                                                               CH                   N      CO.sub.2 CH.sub.3                                                                          H      CH.sub.3                                                                              H      CH.sub.3 CH.sub.3 CH                   N      CO.sub.2 CH.sub.3                                                                          H      CH.sub.3                                                                              H      OCH.sub.3                                                                               OCH.sub.3                                                                               N                    N      CO.sub.2 CH.sub.3                                                                          H      CH.sub.3                                                                              H      OCH.sub.3                                                                               CH.sub.3 N                    N      CO.sub.2 CH.sub.3                                                                          H      CH.sub.3                                                                              H      OC.sub.2 H.sub.5                                                                        NHCH.sub.3                                                                              N                    N      CO.sub.2 CH.sub.3                                                                          H      CH.sub.3                                                                              CH.sub.3                                                                              OCH.sub.3                                                                               CH.sub.3 N                    N      CO.sub.2 CH.sub.3                                                                          H      H      H      OCH.sub.3                                                                               OCH.sub.3                                                                               CH                   N      CO.sub.2 CH.sub.3                                                                          H      H      H      OCH.sub.3                                                                               CH.sub.3 CH                   N      CO.sub.2 CH.sub.3                                                                          H      H      H      Cl       OCH.sub.3                                                                               CH                   N      CO.sub.2 CH.sub.3                                                                          H      H      H      CH.sub.3 CH.sub.3 CH                   N      CO.sub.2 CH.sub.3                                                                          H      H      H      OCH.sub.3                                                                               OCH.sub.3                                                                               N                    N      CO.sub.2 CH.sub.3                                                                          H      H      H      OCH.sub.3                                                                               CH.sub.3 N                    N      CO.sub.2 CH.sub.3                                                                          H      H      H      OC.sub.2 H.sub.5                                                                        NHCH.sub.3                                                                              N                    N      CO.sub.2 CH.sub.3                                                                          H      H      CH.sub.3                                                                              OCH.sub.3                                                                               CH.sub.3 N                    N      CO.sub.2 C.sub.2 H.sub. 5                                                                  H      H      H      OCH.sub.3                                                                               OCH.sub.3                                                                               CH                   N      CO.sub.2 C.sub.2 H.sub.5                                                                   H      H      H      OCH.sub.3                                                                               CH.sub.3 CH                   N      CO.sub.2 C.sub.2 H.sub.5                                                                   H      H      H      Cl       OCH.sub.3                                                                               CH                   N      CO.sub.2 C.sub.2 H.sub.5                                                                   H      H      H      CH.sub.3 CH.sub.3 CH                   N      CO.sub.2 C.sub.2 H.sub.5                                                                   H      H      H      OCH.sub.3                                                                               OCH.sub.3                                                                               N                    N      CO.sub.2 C.sub.2 H.sub.5                                                                   H      H      H      OCH.sub.3                                                                               CH.sub.3 N                    N      CO.sub.2 C.sub.2 H.sub.5                                                                   H      H      H      OC.sub.2 H.sub.5                                                                        NHCH.sub.3                                                                              N                    N      CO.sub.2 C.sub.2 H.sub.5                                                                   H      H      CH.sub.3                                                                              OCH.sub.3                                                                               CH.sub.3 N                    N      CO.sub.2 C.sub.2 H.sub.5                                                                   CH.sub.3                                                                              CH.sub.3                                                                              H      OCH.sub.3                                                                               OCH.sub.3                                                                               CH                   N      CO.sub.2 C.sub.2 H.sub.5                                                                   CH.sub.3                                                                              CH.sub.3                                                                              H      OCH.sub.3                                                                               CH.sub.3 CH                   N      CO.sub.2 C.sub.2 H.sub.5                                                                   CH.sub.3                                                                              CH.sub.3                                                                              H      Cl       OCH.sub.3                                                                               CH                   N      CO.sub.2 C.sub.2 H.sub.5                                                                   CH.sub.3                                                                              CH.sub.3                                                                              H      CH.sub.3 CH.sub.3 CH                   N      CO.sub.2 C.sub.2 H.sub.5                                                                   CH.sub.3                                                                              CH.sub.3                                                                              H      OCH.sub.3                                                                               OCH.sub.3                                                                               N                    N      CO.sub.2 C.sub.2 H.sub.5                                                                   CH.sub.3                                                                              CH.sub.3                                                                              H      OCH.sub.3                                                                               CH.sub.3 N                    N      CO.sub.2 C.sub.2 H.sub.5                                                                   CH.sub.3                                                                              CH.sub.3                                                                              H      OC.sub.2 H.sub.5                                                                        NHCH.sub.3                                                                              N                    N      CO.sub.2 C.sub.2 H.sub.5                                                                   CH.sub.3                                                                              CH.sub.3                                                                              CH.sub.3                                                                              OCH.sub.3                                                                               CH.sub.3 N                    __________________________________________________________________________

                  TABLE 6                                                          ______________________________________                                         General Formula 6                                                              R.sup.2                                                                              R.sup.3 R.sup.4                                                                               R     X      Y       Z.sup.4                              ______________________________________                                         CH.sub.3                                                                             CH.sub.3                                                                               H      H     OCH.sub.3                                                                             OCH.sub.3                                                                              CH                                   CH.sub.3                                                                             CH.sub.3                                                                               H      H     OCH.sub.3                                                                             CH.sub.3                                                                               CH                                   CH.sub.3                                                                             CH.sub.3                                                                               H      H     Cl     OCH.sub.3                                                                              CH                                   CH.sub.3                                                                             CH.sub.3                                                                               H      H     CH.sub.3                                                                              CH.sub.3                                                                               CH                                   CH.sub.3                                                                             CH.sub.3                                                                               H      H     OCH.sub.3                                                                             OCH.sub.3                                                                              N                                    CH.sub.3                                                                             CH.sub.3                                                                               H      H     OCH.sub.3                                                                             CH.sub.3                                                                               N                                    CH.sub.3                                                                             CH.sub.3                                                                               H      H     OC.sub.2 H.sub.5                                                                      NHCH.sub.3                                                                             N                                    CH.sub.3                                                                             CH.sub.3                                                                               H      CH.sub.3                                                                             OCH.sub.3                                                                             CH.sub.3                                                                               N                                    H     CH.sub.3                                                                               H      H     OCH.sub.3                                                                             OCH.sub.3                                                                              CH                                   H     CH.sub.3                                                                               H      H     OCH.sub.3                                                                             CH.sub.3                                                                               CH                                   H     CH.sub.3                                                                               H      H     Cl     OCH.sub.3                                                                              CH                                   H     CH.sub.3                                                                               H      H     CH.sub.3                                                                              CH.sub.3                                                                               CH                                   H     CH.sub.3                                                                               H      H     OCH.sub.3                                                                             OCH.sub.3                                                                              N                                    H     CH.sub.3                                                                               H      H     OCH.sub.3                                                                             CH.sub.3                                                                               N                                    H     CH.sub.3                                                                               H      H     OC.sub.2 H.sub.5                                                                      NHCH.sub.3                                                                             N                                    H     CH.sub.3                                                                               H      CH.sub. 3                                                                            OCH.sub.3                                                                             CH.sub.3                                                                               N                                    CH.sub.3                                                                             H       H      H     OCH.sub.3                                                                             OCH.sub.3                                                                              CH                                   CH.sub.3                                                                             H       H      H     OCH.sub.3                                                                             CH.sub.3                                                                               CH                                   CH.sub.3                                                                             H       H      H     Cl     OCH.sub.3                                                                              CH                                   CH.sub.3                                                                             H       H      H     CH.sub.3                                                                              CH.sub.3                                                                               CH                                   CH.sub.3                                                                             H       H      H     OCH.sub.3                                                                             OCH.sub.3                                                                              N                                    CH.sub.3                                                                             H       H      H     OCH.sub.3                                                                             CH.sub.3                                                                               N                                    CH.sub.3                                                                             H       H      H     OC.sub.2 H.sub.5                                                                      NHCH.sub.3                                                                             N                                    CH.sub.3                                                                             H       H      CH.sub.3                                                                             OCH.sub.3                                                                             CH.sub.3                                                                               N                                    H     H       H      H     OCH.sub.3                                                                             OCH.sub.3                                                                              CH                                   H     H       H      H     OCH.sub.3                                                                             CH.sub.3                                                                               CH                                   H     H       H      H     Cl     OCH.sub.3                                                                              CH                                   H     H       H      H     CH.sub.3                                                                              CH.sub.3                                                                               CH                                   H     H       H      H     OCH.sub.3                                                                             OCH.sub.3                                                                              N                                    H     H       H      H     OCH.sub.3                                                                             CH.sub.3                                                                               N                                    H     H       H      H     OC.sub.2 H.sub.5                                                                      NHCH.sub.3                                                                             N                                    H     H       H      CH.sub.3                                                                             OCH.sub.3                                                                             CH.sub.3                                                                               N                                    ______________________________________                                    

                  TABLE 7                                                          ______________________________________                                         General Formula 7                                                              R.sup.4                                                                            R.sup.1    R.sup.2                                                                               R.sup.3                                                                              R    X     Y      Z.sup.4                          ______________________________________                                         H   H          CH.sub.3                                                                              CH.sub.3                                                                             H    OCH.sub.3                                                                            OCH.sub.3                                                                             CH                               H   H          CH.sub.3                                                                              CH.sub.3                                                                             H    OCH.sub.3                                                                            CH.sub.3                                                                              CH                               H   H          CH.sub.3                                                                              CH.sub.3                                                                             H    Cl    OCH.sub.3                                                                             CH                               H   H          CH.sub.3                                                                              CH.sub.3                                                                             H    CH.sub.3                                                                             CH.sub.3                                                                              CH                               H   H          CH.sub.3                                                                              CH.sub.3                                                                             H    OCH.sub.3                                                                            OCH.sub.3                                                                             N                                H   H          CH.sub.3                                                                              CH.sub.3                                                                             H    OCH.sub.3                                                                            CH.sub.3                                                                              N                                H   H          CH.sub.3                                                                              CH.sub.3                                                                             H    OC.sub.2 H.sub.5                                                                     NHCH.sub.3                                                                            N                                H   H          CH.sub.3                                                                              CH.sub.3                                                                             CH.sub.3                                                                            OCH.sub.3                                                                            CH.sub.3                                                                              N                                H   Cl         CH.sub.3                                                                              CH.sub.3                                                                             H    OCH.sub.3                                                                            OCH.sub.3                                                                             CH                               H   Cl         CH.sub.3                                                                              CH.sub.3                                                                             H    OCH.sub.3                                                                            CH.sub.3                                                                              CH                               H   Cl         CH.sub.3                                                                              CH.sub.3                                                                             H    Cl    OCH.sub.3                                                                             CH                               H   Cl         CH.sub.3                                                                              CH.sub.3                                                                             H    CH.sub.3                                                                             CH.sub.3                                                                              CH                               H   Cl         CH.sub.3                                                                              CH.sub. 3                                                                            H    OCH.sub.3                                                                            OCH.sub.3                                                                             N                                H   Cl         CH.sub.3                                                                              CH.sub.3                                                                             H    OCH.sub.3                                                                            CH.sub.3                                                                              N                                H   Cl         CH.sub.3                                                                              CH.sub.3                                                                             H    OC.sub.2 H.sub.5                                                                     NHCH.sub.3                                                                            N                                H   Cl         CH.sub.3                                                                              CH.sub.3                                                                             CH.sub.3                                                                            OCH.sub.3                                                                            CH.sub.3                                                                              N                                H   SO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                              CH.sub.3                                                                             H    OCH.sub.3                                                                            OCH.sub.3                                                                             CH                               H   SO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                              CH.sub.3                                                                             H    OCH.sub.3                                                                            CH.sub.3                                                                              CH                               H   SO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                              CH.sub.3                                                                             H    Cl    OCH.sub.3                                                                             CH                               H   SO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                              CH.sub.3                                                                             H    CH.sub.3                                                                             CH.sub.3                                                                              CH                               H   SO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                              CH.sub.3                                                                             H    OCH.sub.3                                                                            OCH.sub.3                                                                             N                                H   SO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                              CH.sub.3                                                                             H    OCH.sub.3                                                                            CH.sub.3                                                                              N                                H   SO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                              CH.sub.3                                                                             H    OC.sub.2 H.sub.5                                                                     NHCH.sub.3                                                                            N                                H   SO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                              CH.sub.3                                                                             CH.sub.3                                                                            OCH.sub.3                                                                            CH.sub.3                                                                              N                                H   SO.sub.2 N(CH.sub.3).sub.2                                                                CH.sub.3                                                                              CH.sub.3                                                                             H    OCH.sub.3                                                                            OCH.sub.3                                                                             CH                               H   SO.sub. 2 N(CH.sub.3).sub.2                                                               CH.sub.3                                                                              CH.sub.3                                                                             H    OCH.sub.3                                                                            CH.sub.3                                                                              CH                               H   SO.sub.2 N(CH.sub.3).sub.2                                                                CH.sub.3                                                                              CH.sub.3                                                                             H    Cl    OCH.sub.3                                                                             CH                               H   SO.sub.2 N(CH.sub.3).sub.2                                                                CH.sub.3                                                                              CH.sub.3                                                                             H    OCH.sub.3                                                                            OCH.sub.3                                                                             N                                H   SO.sub.2 N(CH.sub.3).sub.2                                                                CH.sub.3                                                                              CH.sub.3                                                                             H    OCH.sub.3                                                                            CH.sub.3                                                                              N                                H   H          H      H     H    OCH.sub.3                                                                            OCH.sub.3                                                                             CH                               H   H          H      H     H    OCH.sub.3                                                                            CH.sub.3                                                                              CH                               H   H          H      H     H    Cl    OCH.sub.3                                                                             CH                               H   H          H      H     H    CH.sub.3                                                                             CH.sub.3                                                                              CH                               H   H          H      H     H    OCH.sub.3                                                                            OCH.sub.3                                                                             N                                H   H          H      H     H    OCH.sub.3                                                                            CH.sub.3                                                                              N                                H   H          H      H     H    OC.sub.2 H.sub.5                                                                     NHCH.sub.3                                                                            N                                H   H          H      H     CH.sub.3                                                                            OCH.sub.3                                                                            CH.sub.3                                                                              N                                H   Cl         H      H     H    OCH.sub.3                                                                            OCH.sub.3                                                                             CH                               H   Cl         H      H     H    OCH.sub.3                                                                            CH.sub.3                                                                              CH                               H   Cl         H      H     H    Cl    OCH.sub.3                                                                             CH                               H   Cl         H      H     H    CH.sub.3                                                                             CH.sub.3                                                                              CH                               H   Cl         H      H     H    OCH.sub.3                                                                            OCH.sub.3                                                                             N                                H   Cl         H      H     H    OCH.sub.3                                                                            CH.sub.3                                                                              N                                H   Cl         H      H     H    OC.sub.2 H.sub.5                                                                     NHCH.sub.3                                                                            N                                H   Cl         H      H     CH.sub.3                                                                            OCH.sub.3                                                                            CH.sub.3                                                                              N                                H   SO.sub.2 CH.sub.3                                                                         H      H     H    OCH.sub.3                                                                            OCH.sub.3                                                                             CH                               H   SO.sub.2 CH.sub.3                                                                         H      H     H    OCH.sub.3                                                                            CH.sub.3                                                                              CH                               H   SO.sub.2 CH.sub.3                                                                         H      H     H    Cl    OCH.sub.3                                                                             CH                               H   SO.sub.2 CH.sub.3                                                                         H      H     H    CH.sub.3                                                                             CH.sub.3                                                                              CH                               H   SO.sub.2 CH.sub.3                                                                         H      H     H    OCH.sub.3                                                                            OCH.sub.3                                                                             N                                H   SO.sub.2 CH.sub.3                                                                         H      H     H    OCH.sub.3                                                                            CH.sub.3                                                                              N                                H   SO.sub.2 CH.sub.3                                                                         H      H     H    OC.sub.2 H.sub.5                                                                     NHCH.sub.3                                                                            N                                H   SO.sub.2 CH.sub.3                                                                         H      H     CH.sub.3                                                                            OCH.sub.3                                                                            CH.sub.3                                                                              N                                H   SO.sub.2 N(CH.sub.3).sub.2                                                                H      H     H    OCH.sub.3                                                                            OCH.sub.3                                                                             CH                               H   SO.sub.2 N(CH.sub.3).sub.2                                                                H      H     H    OCH.sub.3                                                                            CH.sub.3                                                                              CH                               H   SO.sub.2 N(CH.sub.3).sub.2                                                                H      H     H    Cl    OCH.sub.3                                                                             CH                               H   SO.sub.2 N(CH.sub. 3).sub.2                                                               H      H     H    OCH.sub.3                                                                            OCH.sub.3                                                                             N                                H   SO.sub.2 N(CH.sub.3).sub.2                                                                H      H     H    OCH.sub.3                                                                            CH.sub.3                                                                              N                                H   H          H      CH.sub.3                                                                             H    OCH.sub.3                                                                            OCH.sub.3                                                                             CH                               H   H          H      CH.sub.3                                                                             H    OCH.sub.3                                                                            CH.sub.3                                                                              CH                               H   H          H      CH.sub.3                                                                             H    Cl    OCH.sub.3                                                                             CH                               H   H          H      CH.sub.3                                                                             H    CH.sub.3                                                                             CH.sub.3                                                                              CH                               H   H          H      CH.sub.3                                                                             H    OCH.sub.3                                                                            OCH.sub.3                                                                             N                                H   H          H      CH.sub.3                                                                             H    OCH.sub.3                                                                            CH.sub.3                                                                              N                                H   H          H      CH.sub.3                                                                             H    OC.sub.2 H.sub.5                                                                     NHCH.sub.3                                                                            N                                H   H          H      CH.sub.3                                                                             CH.sub.3                                                                            OCH.sub.3                                                                            CH.sub.3                                                                              N                                H   Cl         H      CH.sub.3                                                                             H    OCH.sub.3                                                                            OCH.sub.3                                                                             CH                               H   Cl         H      CH.sub.3                                                                             H    OCH.sub.3                                                                            CH.sub.3                                                                              CH                               H   Cl         H      CH.sub.3                                                                             H    Cl    OCH.sub.3                                                                             CH                               H   Cl         H      CH.sub.3                                                                             H    CH.sub.3                                                                             CH.sub.3                                                                              CH                               H   Cl         H      CH.sub.3                                                                             H    OCH.sub.3                                                                            OCH.sub.3                                                                             N                                H   Cl         H      CH.sub.3                                                                             H    OCH.sub.3                                                                            CH.sub.3                                                                              N                                H   Cl         H      CH.sub.3                                                                             H    OC.sub.2 H.sub.5                                                                     NHCH.sub.3                                                                            N                                H   Cl         H      CH.sub.3                                                                             CH.sub. 3                                                                           OCH.sub.3                                                                            CH.sub.3                                                                              N                                H   SO.sub.2 CH.sub.3                                                                         H      CH.sub.3                                                                             H    OCH.sub.3                                                                            OCH.sub.3                                                                             CH                               H   SO.sub.2 CH.sub.3                                                                         H      CH.sub.3                                                                             H    OCH.sub.3                                                                            CH.sub.3                                                                              CH                               H   SO.sub.2 CH.sub.3                                                                         H      CH.sub.3                                                                             H    Cl    OCH.sub.3                                                                             CH                               H   SO.sub.2 CH.sub.3                                                                         H      CH.sub.3                                                                             H    CH.sub.3                                                                             CH.sub.3                                                                              CH                               H   SO.sub.2 CH.sub.3                                                                         H      CH.sub.3                                                                             H    OCH.sub.3                                                                            OCH.sub.3                                                                             N                                H   SO.sub.2 CH.sub.3                                                                         H      CH.sub.3                                                                             H    OCH.sub.3                                                                            CH.sub.3                                                                              N                                H   SO.sub.2 CH.sub.3                                                                         H      CH.sub.3                                                                             H    OC.sub.2 H.sub.5                                                                     NHCH.sub.3                                                                            N                                H   SO.sub.2 CH.sub.3                                                                         H      CH.sub.3                                                                             H    OCH.sub.3                                                                            CH.sub.3                                                                              N                                H   SO.sub.2 N(CH.sub.3).sub.2                                                                H      CH.sub.3                                                                             H    OCH.sub.3                                                                            OCH.sub.3                                                                             CH                               H   SO.sub.2 N(CH.sub.3).sub.2                                                                H      CH.sub.3                                                                             H    OCH.sub.3                                                                            CH.sub.3                                                                              CH                               H   SO.sub.2 N(CH.sub.3).sub.2                                                                H      CH.sub.3                                                                             H    Cl    OCH.sub.3                                                                             CH                               H   SO.sub.2 N(CH.sub.3).sub.2                                                                H      CH.sub.3                                                                             H    OCH.sub.3                                                                            OCH.sub.3                                                                             N                                H   SO.sub.2 N(CH.sub.3).sub.2                                                                H      CH.sub.3                                                                             H    OCH.sub.3                                                                            CH.sub.3                                                                              N                                H   CO.sub. 2 CH.sub.3                                                                        CH.sub.3                                                                              CH.sub.3                                                                             H    OCH.sub.3                                                                            OCH.sub.3                                                                             CH                               H   CO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                              CH.sub.3                                                                             H    OCH.sub.3                                                                            CH.sub.3                                                                              CH                               H   CO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                              CH.sub.3                                                                             H    Cl    OCH.sub.3                                                                             CH                               H   CO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                              CH.sub.3                                                                             H    CH.sub.3                                                                             CH.sub.3                                                                              CH                               H   CO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                              CH.sub.3                                                                             H    OCH.sub.3                                                                            OCH.sub.3                                                                             N                                H   CO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                              CH.sub.3                                                                             H    OCH.sub.3                                                                            CH.sub.3                                                                              N                                H   CO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                              CH.sub.3                                                                             H    OC.sub.2 H.sub.5                                                                     NHCH.sub.3                                                                            N                                H   CO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                              CH.sub.3                                                                             CH.sub.3                                                                            OCH.sub.3                                                                            CH.sub.3                                                                              N                                H   CO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                              H     H    OCH.sub.3                                                                            OCH.sub.3                                                                             CH                               H   CO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                              H     H    OCH.sub.3                                                                            CH.sub.3                                                                              CH                               H   CO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                              H     H    Cl    OCH.sub.3                                                                             CH                               H   CO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                              H     H    CH.sub.3                                                                             CH.sub.3                                                                              CH                               H   CO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                              H     H    OCH.sub.3                                                                            OCH.sub.3                                                                             N                                H   CO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                              H     H    OCH.sub.3                                                                            CH.sub.3                                                                              N                                H   CO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                              H     H    OC.sub.2 H.sub.5                                                                     NHCH.sub.3                                                                            N                                H   CO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                              H     CH.sub.3                                                                            OCH.sub.3                                                                            CH.sub.3                                                                              N                                H   CO.sub.2 CH.sub.3                                                                         H      CH.sub.3                                                                             H    OCH.sub.3                                                                            OCH.sub.3                                                                             CH                               H   CO.sub.2 CH.sub.3                                                                         H      CH.sub.3                                                                             H    OCH.sub.3                                                                            CH.sub.3                                                                              CH                               H   CO.sub.2 CH.sub.3                                                                         H      CH.sub.3                                                                             H    Cl    OCH.sub.3                                                                             CH                               H   CO.sub.2 CH.sub.3                                                                         H      CH.sub.3                                                                             H    CH.sub.3                                                                             CH.sub.3                                                                              CH                               H   CO.sub.2 CH.sub.3                                                                         H      CH.sub.3                                                                             H    OCH.sub.3                                                                            OCH.sub.3                                                                             N                                H   CO.sub.2 CH.sub.3                                                                         H      CH.sub.3                                                                             H    OCH.sub.3                                                                            CH.sub.3                                                                              N                                H   CO.sub.2 CH.sub.3                                                                         H      CH.sub.3                                                                             H    OC.sub.2 H.sub.5                                                                     NHCH.sub.3                                                                            N                                H   CO.sub.2 CH.sub.3                                                                         H      CH.sub.3                                                                             CH.sub.3                                                                            OCH.sub.3                                                                            CH.sub.3                                                                              N                                H   CO.sub.2 CH.sub.3                                                                         H      H     H    OCH.sub.3                                                                            OCH.sub.3                                                                             CH                               H   CO.sub.2 CH.sub.3                                                                         H      H     H    OCH.sub.3                                                                            CH.sub.3                                                                              CH                               H   CO.sub.2 CH.sub.3                                                                         H      H     H    Cl    OCH.sub.3                                                                             CH                               H   CO.sub.2 CH.sub.3                                                                         H      H     H    CH.sub.3                                                                             CH.sub.3                                                                              CH                               H   CO.sub.2 CH.sub.3                                                                         H      H     H    OCH.sub.3                                                                            OCH.sub.3                                                                             N                                H   CO.sub.2 CH.sub.3                                                                         H      H     H    OCH.sub.3                                                                            CH.sub.3                                                                              N                                H   CO.sub.2 CH.sub.3                                                                         H      H     H    OC.sub.2 H.sub.5                                                                     NHCH.sub.3                                                                            N                                H   CO.sub.2 CH.sub.3                                                                         H      H     CH.sub.3                                                                            OCH.sub.3                                                                            CH.sub.3                                                                              N                                H   CO.sub.2 C.sub.2 H.sub.5                                                                  H      H     H    OCH.sub.3                                                                            OCH.sub.3                                                                             CH                               H   CO.sub.2 C.sub.2 H.sub.5                                                                  H      H     H    OCH.sub.3                                                                            CH.sub.3                                                                              CH                               H   CO.sub.2 C.sub.2 H.sub.5                                                                  H      H     H    Cl    OCH.sub.3                                                                             CH                               H   CO.sub.2 C.sub.2 H.sub.5                                                                  H      H     H    CH.sub.3                                                                             CH.sub.3                                                                              CH                               H   CO.sub.2 C.sub.2 H.sub.5                                                                  H      H     H    OCH.sub.3                                                                            OCH.sub.3                                                                             N                                H   CO.sub.2 C.sub.2 H.sub.5                                                                  H      H     H    OCH.sub.3                                                                            CH.sub.3                                                                              N                                H   CO.sub.2 C.sub.2 H.sub.5                                                                  H      H     H    OC.sub.2 H.sub.5                                                                     NHCH.sub.3                                                                            N                                H   CO.sub.2 C.sub.2 H.sub.5                                                                  H      H     CH.sub.3                                                                            OCH.sub.3                                                                            CH.sub.3                                                                              N                                H   CO.sub.2 C.sub.2 H.sub.5                                                                  CH.sub.3                                                                              CH.sub.3                                                                             H    OCH.sub.3                                                                            OCH.sub.3                                                                             CH                               H   CO.sub.2 C.sub.2 H.sub.5                                                                  CH.sub.3                                                                              CH.sub.3                                                                             H    OCH.sub.3                                                                            CH.sub.3                                                                              CH                               H   CO.sub.2 C.sub.2 H.sub.5                                                                  CH.sub.3                                                                              CH.sub.3                                                                             H    Cl    OCH.sub.3                                                                             CH                               H   CO.sub.2 C.sub.2 H.sub.5                                                                  CH.sub.3                                                                              CH.sub.3                                                                             H    CH.sub.3                                                                             CH.sub.3                                                                              CH                               H   CO.sub.2 C.sub.2 H.sub.5                                                                  CH.sub.3                                                                              CH.sub.3                                                                             H    OCH.sub.3                                                                            OCH.sub.3                                                                             N                                H   CO.sub.2 C.sub.2 H.sub.5                                                                  CH.sub.3                                                                              CH.sub.3                                                                             H    OCH.sub.3                                                                            CH.sub.3                                                                              N                                H   CO.sub.2 C.sub.2 H.sub.5                                                                  CH.sub.3                                                                              CH.sub.3                                                                             H    OC.sub.2 H.sub.5                                                                     NHCH.sub.3                                                                            N                                H   CO.sub.2 C.sub.2 H.sub.5                                                                  CH.sub.3                                                                              CH.sub.3                                                                             CH.sub.3                                                                            OCH.sub.3                                                                            CH.sub.3                                                                              N                                H   H          CH.sub.3                                                                              H     H    OCH.sub.3                                                                            OCH.sub.3                                                                             CH                               H   H          CH.sub.3                                                                              H     H    OCH.sub.3                                                                            CH.sub.3                                                                              CH                               H   H          CH.sub.3                                                                              H     H    Cl    OCH.sub.3                                                                             CH                               H   H          CH.sub.3                                                                              H     H    CH.sub.3                                                                             CH.sub.3                                                                              CH                               H   H          CH.sub.3                                                                              H     H    OCH.sub.3                                                                            OCH.sub.3                                                                             N                                ______________________________________                                    

                                      TABLE 8                                      __________________________________________________________________________     General Formula 8                                                              Z.sup.1                                                                            R.sup.1 R.sup.2                                                                           R.sup.3                                                                           R.sup.5                                                                          R  X   Y     Z.sup.4                                       __________________________________________________________________________     CH  H       CH.sub.3                                                                          CH.sub.3                                                                          H H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH                                            CH  H       CH.sub.3                                                                          CH.sub.3                                                                          H H  OCH.sub.3                                                                          CH.sub.3                                                                             CH                                            CH  H       CH.sub.3                                                                          CH.sub.3                                                                          H H  Cl  OCH.sub.3                                                                            CH                                            CH  H       CH.sub.3                                                                          CH.sub.3                                                                          H H  CH.sub.3                                                                           CH.sub.3                                                                             CH                                            CH  H       CH.sub.3                                                                          CH.sub.3                                                                          H H  OCH.sub.3                                                                          OCH.sub.3                                                                            N                                             CH  H       CH.sub.3                                                                          CH.sub.3                                                                          H H  OCH.sub.3                                                                          CH.sub.3                                                                             N                                             CH  H       CH.sub.3                                                                          CH.sub.3                                                                          H H  OC.sub.2 H.sub.5                                                                   NHCH.sub.3                                                                           N                                             CH  H       CH.sub.3                                                                          CH.sub.3                                                                          H CH.sub.3                                                                          OCH.sub.3                                                                          CH.sub.3                                                                             N                                             CH  Cl      CH.sub.3                                                                          CH.sub.3                                                                          H H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH                                            CH  Cl      CH.sub.3                                                                          CH.sub.3                                                                          H H  OCH.sub.3                                                                          CH.sub.3                                                                             CH                                            CH  Cl      CH.sub.3                                                                          CH.sub.3                                                                          H H  Cl  OCH.sub.3                                                                            CH                                            CH  Cl      CH.sub.3                                                                          CH.sub.3                                                                          H H  CH.sub.3                                                                           CH.sub.3                                                                             CH                                            CH  Cl      CH.sub.3                                                                          CH.sub.3                                                                          H H  OCH.sub.3                                                                          OCH.sub.3                                                                            N                                             CH  Cl      CH.sub.3                                                                          CH.sub.3                                                                          H H  OCH.sub.3                                                                          CH.sub.3                                                                             N                                             CH  Cl      CH.sub.3                                                                          CH.sub.3                                                                          H H  OC.sub.2 H.sub.5                                                                   NHCH.sub.3                                                                           N                                             CH  Cl      CH.sub.3                                                                          CH.sub.3                                                                          H CH.sub.3                                                                          OCH.sub.3                                                                          CH.sub.3                                                                             N                                             CH  SO.sub.2 CH.sub.3                                                                      CH.sub.3                                                                          CH.sub.3                                                                          H H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH                                            CH  SO.sub.2 CH.sub.3                                                                      CH.sub.3                                                                          CH.sub.3                                                                          H H  OCH.sub.3                                                                          CH.sub.3                                                                             CH                                            CH  SO.sub.2 CH.sub.3                                                                      CH.sub.3                                                                          CH.sub.3                                                                          H H  Cl  OCH.sub.3                                                                            CH                                            CH  SO.sub.2 CH.sub.3                                                                      CH.sub.3                                                                          CH.sub.3                                                                          H H  CH.sub.3                                                                           CH.sub.3                                                                             CH                                            CH  SO.sub.2 CH.sub.3                                                                      CH.sub.3                                                                          CH.sub.3                                                                          H H  OCH.sub.3                                                                          OCH.sub.3                                                                            N                                             CH  SO.sub.2 CH.sub.3                                                                      CH.sub.3                                                                          CH.sub.3                                                                          H H  OCH.sub.3                                                                          CH.sub.3                                                                             N                                             CH  SO.sub.2 CH.sub.3                                                                      CH.sub.3                                                                          CH.sub.3                                                                          H H  OC.sub.2 H.sub.5                                                                   NHCH.sub.3                                                                           N                                             CH  SO.sub.2 CH.sub.3                                                                      CH.sub.3                                                                          CH.sub.3                                                                          H CH.sub.3                                                                          OCH.sub.3                                                                          CH.sub.3                                                                             N                                             CH  SO.sub.2 N(CH.sub.3).sub.2                                                             CH.sub.3                                                                          CH.sub.3                                                                          H H  OCH.sub.3                                                                          OCH.sub. 3                                                                           CH                                            CH  SO.sub.2 N(CH.sub.3).sub.2                                                             CH.sub.3                                                                          CH.sub.3                                                                          H H  OCH.sub.3                                                                          CH.sub.3                                                                             CH                                            CH  SO.sub.2 N(CH.sub.3).sub.2                                                             CH.sub.3                                                                          CH.sub.3                                                                          H H  Cl  OCH.sub.3                                                                            CH                                            CH  SO.sub.2 N(CH.sub.3).sub.2                                                             CH.sub.3                                                                          CH.sub.3                                                                          H H  OCH.sub.3                                                                          OCH.sub.3                                                                            N                                             CH  SO.sub.2 N(CH.sub.3).sub.2                                                             CH.sub.3                                                                          CH.sub.3                                                                          H H  OCH.sub.3                                                                          CH.sub.3                                                                             N                                             N   H       CH.sub.3                                                                          CH.sub.3                                                                          H H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH                                            N   H       CH.sub.3                                                                          CH.sub.3                                                                          H H  OCH.sub.3                                                                          CH.sub.3                                                                             CH                                            N   H       CH.sub.3                                                                          CH.sub.3                                                                          H H  Cl  OCH.sub.3                                                                            CH                                            N   H       CH.sub.3                                                                          CH.sub.3                                                                          H H  CH.sub.3                                                                           CH.sub.3                                                                             CH                                            N   H       CH.sub.3                                                                          CH.sub.3                                                                          H H  OCH.sub.3                                                                          OCH.sub.3                                                                            N                                             N   H       CH.sub.3                                                                          CH.sub.3                                                                          H H  OCH.sub.3                                                                          CH.sub.3                                                                             N                                             N   H       CH.sub.3                                                                          CH.sub.3                                                                          H H  OC.sub.2 H.sub.5                                                                   NHCH.sub.3                                                                           N                                             N   H       CH.sub.3                                                                          CH.sub.3                                                                          H CH.sub.3                                                                          OCH.sub.3                                                                          CH.sub.3                                                                             N                                             N   Cl      CH.sub.3                                                                          CH.sub.3                                                                          H H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH                                            N   Cl      CH.sub.3                                                                          CH.sub.3                                                                          H H  OCH.sub.3                                                                          CH.sub.3                                                                             CH                                            N   Cl      CH.sub.3                                                                          CH.sub.3                                                                          H H  Cl  OCH.sub.3                                                                            CH                                            N   Cl      CH.sub.3                                                                          CH.sub.3                                                                          H H  CH.sub.3                                                                           CH.sub.3                                                                             CH                                            N   Cl      CH.sub.3                                                                          CH.sub.3                                                                          H H  OCH.sub.3                                                                          OCH.sub.3                                                                            N                                             N   Cl      CH.sub.3                                                                          CH.sub.3                                                                          H H  OCH.sub.3                                                                          CH.sub.3                                                                             N                                             N   Cl      CH.sub.3                                                                          CH.sub.3                                                                          H H  OC.sub.2 H.sub.5                                                                   NHCH.sub.3                                                                           N                                             N   Cl      CH.sub.3                                                                          CH.sub.3                                                                          H CH.sub.3                                                                          OCH.sub.3                                                                          CH.sub.3                                                                             N                                             N   SO.sub.2 CH.sub.3                                                                      CH.sub.3                                                                          CH.sub.3                                                                          H H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH                                            N   SO.sub.2 CH.sub.3                                                                      CH.sub.3                                                                          CH.sub.3                                                                          H H  OCH.sub.3                                                                          CH.sub.3                                                                             CH                                            N   SO.sub.2 CH.sub.3                                                                      CH.sub.3                                                                          CH.sub.3                                                                          H H  Cl  OCH.sub.3                                                                            CH                                            N   SO.sub.2 CH.sub.3                                                                      CH.sub.3                                                                          CH.sub.3                                                                          H H  CH.sub.3                                                                           CH.sub.3                                                                             CH                                            N   SO.sub.2 CH.sub.3                                                                      CH.sub.3                                                                          CH.sub.3                                                                          H H  OCH.sub.3                                                                          OCH.sub.3                                                                            N                                             N   SO.sub.2 CH.sub.3                                                                      CH.sub.3                                                                          CH.sub.3                                                                          H H  OCH.sub.3                                                                          CH.sub.3                                                                             N                                             N   SO.sub.2 CH.sub.3                                                                      CH.sub.3                                                                          CH.sub.3                                                                          H H  OC.sub.2 H.sub.5                                                                   NHCH.sub.3                                                                           N                                             N   SO.sub. 2 CH.sub.3                                                                     CH.sub.3                                                                          CH.sub.3                                                                          H CH.sub.3                                                                          OCH.sub.3                                                                          CH.sub.3                                                                             N                                             N   SO.sub.2 N(CH.sub.3).sub.2                                                             CH.sub.3                                                                          CH.sub.3                                                                          H H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH                                            N   SO.sub.2 N(CH.sub.3).sub.2                                                             CH.sub.3                                                                          CH.sub.3                                                                          H H  OCH.sub.3                                                                          CH.sub.3                                                                             CH                                            N   SO.sub.2 N(CH.sub.3).sub.2                                                             CH.sub.3                                                                          CH.sub.3                                                                          H H  Cl  OCH.sub.3                                                                            CH                                            N   SO.sub.2 N(CH.sub.3).sub.2                                                             CH.sub.3                                                                          CH.sub.3                                                                          H H  OCH.sub.3                                                                          OCH.sub.3                                                                            N                                             N   SO.sub.2 N(CH.sub.3).sub.2                                                             CH.sub.3                                                                          CH.sub.3                                                                          H H  OCH.sub.3                                                                          CH.sub.3                                                                             N                                             N   H       H  H  H H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH                                            N   H       H  H  H H  OCH.sub.3                                                                          CH.sub.3                                                                             CH                                            N   H       H  H  H H  Cl  OCH.sub.3                                                                            CH                                            N   H       H  H  H H  CH.sub.3                                                                           CH.sub.3                                                                             CH                                            N   H       H  H  H H  OCH.sub.3                                                                          OCH.sub.3                                                                            N                                             N   H       H  H  H H  OCH.sub.3                                                                          CH.sub.3                                                                             N                                             N   H       H  H  H H  OC.sub.2 H.sub.5                                                                   NHCH.sub.3                                                                           N                                             N   H       H  H  H CH.sub.3                                                                          OCH.sub.3                                                                          CH.sub.3                                                                             N                                             N   Cl      H  H  H H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH                                            N   Cl      H  H  H H  OCH.sub.3                                                                          CH.sub.3                                                                             CH                                            N   Cl      H  H  H H  Cl  OCH.sub.3                                                                            CH                                            N   Cl      H  H  H H  CH.sub.3                                                                           CH.sub.3                                                                             CH                                            N   Cl      H  H  H H  OCH.sub.3                                                                          OCH.sub.3                                                                            N                                             N   Cl      H  H  H H  OCH.sub.3                                                                          CH.sub.3                                                                             N                                             N   Cl      H  H  H H  OC.sub.2 H.sub.5                                                                   NHCH.sub.3                                                                           N                                             N   Cl      H  H  H CH.sub.3                                                                          OCH.sub.3                                                                          CH.sub.3                                                                             N                                             N   SO.sub.2 CH.sub.3                                                                      H  H  H H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH                                            N   SO.sub.2 CH.sub.3                                                                      H  H  H H  OCH.sub.3                                                                          CH.sub.3                                                                             CH                                            N   SO.sub.2 CH.sub.3                                                                      H  H  H H  Cl  OCH.sub.3                                                                            CH                                            N   SO.sub.2 CH.sub.3                                                                      H  H  H H  CH.sub.3                                                                           CH.sub.3                                                                             CH                                            N   SO.sub.2 CH.sub.3                                                                      H  H  H H  OCH.sub.3                                                                          OCH.sub.3                                                                            N                                             N   SO.sub.2 CH.sub.3                                                                      H  H  H H  OCH.sub.3                                                                          CH.sub.3                                                                             N                                             N   SO.sub.2 CH.sub.3                                                                      H  H  H H  OC.sub.2 H.sub.5                                                                   NHCH.sub.3                                                                           N                                             N   SO.sub.2 CH.sub.3                                                                      H  H  H CH.sub.3                                                                          OCH.sub.3                                                                          CH.sub.3                                                                             N                                             N   SO.sub. 2 N(CH.sub.3).sub.2                                                            H  H  H H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH                                            N   SO.sub.2 N(CH.sub.3).sub.2                                                             H  H  H H  OCH.sub.3                                                                          CH.sub.3                                                                             CH                                            N   SO.sub.2 N(CH.sub.3).sub.2                                                             H  H  H H  Cl  OCH.sub.3                                                                            CH                                            N   SO.sub.2 N(CH.sub.3).sub.2                                                             H  H  H H  OCH.sub.3                                                                          OCH.sub.3                                                                            N                                             N   SO.sub.2 N(CH.sub.3).sub.2                                                             H  H  H H  OCH.sub.3                                                                          CH.sub.3                                                                             N                                             CH  H       H  H  H H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH                                            CH  H       H  H  H H  OCH.sub.3                                                                          CH.sub.3                                                                             CH                                            CH  H       H  H  H H  Cl  OCH.sub.3                                                                            CH                                            CH  H       H  H  H H  CH.sub.3                                                                           CH.sub.3                                                                             CH                                            CH  H       H  H  H H  OCH.sub.3                                                                          OCH.sub.3                                                                            N                                             CH  H       H  H  H H  OCH.sub.3                                                                          CH.sub.3                                                                             N                                             CH  H       H  H  H H  OC.sub.2 H.sub.5                                                                   NHCH.sub.3                                                                           N                                             CH  H       H  H  H CH.sub.3                                                                          OCH.sub.3                                                                          CH.sub.3                                                                             N                                             CH  Cl      H  H  H H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH                                            CH  Cl      H  H  H H  OCH.sub.3                                                                          CH.sub.3                                                                             CH                                            CH  Cl      H  H  H H  Cl  OCH.sub.3                                                                            CH                                            CH  Cl      H  H  H H  CH.sub.3                                                                           CH.sub.3                                                                             CH                                            CH  Cl      H  H  H H  OCH.sub.3                                                                          OCH.sub.3                                                                            N                                             CH  Cl      H  H  H H  OCH.sub.3                                                                          CH.sub.3                                                                             N                                             CH  Cl      H  H  H H  OC.sub.2 H.sub.5                                                                   NHCH.sub.3                                                                           N                                             CH  Cl      H  H  H CH.sub.3                                                                          OCH.sub.3                                                                          CH.sub.3                                                                             N                                             CH  SO.sub.2 CH.sub.3                                                                      H  H  H H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH                                            CH  SO.sub.2 CH.sub.3                                                                      H  H  H H  OCH.sub.3                                                                          CH.sub.3                                                                             CH                                            CH  SO.sub.2 CH.sub.3                                                                      H  H  H H  Cl  OCH.sub.3                                                                            CH                                            CH  SO.sub.2 CH.sub.3                                                                      H  H  H H  CH.sub.3                                                                           CH.sub.3                                                                             CH                                            CH  SO.sub.2 CH.sub.3                                                                      H  H  H H  OCH.sub.3                                                                          OCH.sub.3                                                                            N                                             CH  SO.sub.2 CH.sub.3                                                                      H  H  H H  OCH.sub.3                                                                          CH.sub.3                                                                             N                                             CH  SO.sub.2 CH.sub.3                                                                      H  H  H H  OC.sub.2 H.sub.5                                                                   NHCH.sub.3                                                                           N                                             CH  SO.sub.2 CH.sub.3                                                                      H  H  H CH.sub.3                                                                          OCH.sub.3                                                                          CH.sub.3                                                                             N                                             CH  SO.sub.2 N(CH.sub.3).sub.2                                                             H  H  H H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH                                            CH  SO.sub.2 N(CH.sub.3).sub.2                                                             H  H  H H  OCH.sub.3                                                                          CH.sub.3                                                                             CH                                            CH  SO.sub.2 N(CH.sub.3).sub.2                                                             H  H  H H  Cl  OCH.sub.3                                                                            CH                                            CH  SO.sub.2 N(CH.sub.3).sub.2                                                             H  H  H H  OCH.sub.3                                                                          OCH.sub.3                                                                            N                                             CH  SO.sub.2 N(CH.sub.3).sub.2                                                             H  H  H H  OCH.sub.3                                                                          CH.sub.3                                                                             N                                             N   CO.sub.2 CH.sub.3                                                                      CH.sub.3                                                                          CH.sub.3                                                                          H H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH                                            N   CO.sub.2 CH.sub.3                                                                      CH.sub.3                                                                          CH.sub.3                                                                          H H  OCH.sub.3                                                                          CH.sub.3                                                                             CH                                            N   CO.sub.2 CH.sub.3                                                                      CH.sub.3                                                                          CH.sub.3                                                                          H H  Cl  OCH.sub.3                                                                            CH                                            N   CO.sub.2 CH.sub.3                                                                      CH.sub.3                                                                          CH.sub.3                                                                          H H  CH.sub.3                                                                           CH.sub.3                                                                             CH                                            N   CO.sub.2 CH.sub.3                                                                      CH.sub.3                                                                          CH.sub.3                                                                          H H  OCH.sub.3                                                                          OCH.sub.3                                                                            N                                             N   CO.sub.2 CH.sub.3                                                                      CH.sub.3                                                                          CH.sub.3                                                                          H H  OCH.sub.3                                                                          CH.sub.3                                                                             N                                             N   CO.sub.2 CH.sub.3                                                                      CH.sub.3                                                                          CH.sub.3                                                                          H H  OC.sub.2 H.sub.5                                                                   NHCH.sub.3                                                                           N                                             N   CO.sub.2 CH.sub.3                                                                      CH.sub.3                                                                          CH.sub.3                                                                          H CH.sub.3                                                                          OCH.sub.3                                                                          CH.sub.3                                                                             N                                             N   CO.sub.2 CH.sub.3                                                                      H  H  H H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH                                            N   CO.sub.2 CH.sub.3                                                                      H  H  H H  OCH.sub.3                                                                          CH.sub.3                                                                             CH                                            N   CO.sub.2 CH.sub.3                                                                      H  H  H H  Cl  OCH.sub.3                                                                            CH                                            N   CO.sub.2 CH.sub.3                                                                      H  H  H H  CH.sub.3                                                                           CH.sub.3                                                                             CH                                            N   CO.sub.2 CH.sub.3                                                                      H  H  H H  OCH.sub.3                                                                          OCH.sub.3                                                                            N                                             N   CO.sub.2 CH.sub.3                                                                      H  H  H H  OCH.sub.3                                                                          CH.sub.3                                                                             N                                             N   CO.sub.2 CH.sub.3                                                                      H  H  H H  OC.sub.2 H.sub.5                                                                   NHCH.sub.3                                                                           N                                             N   CO.sub.2 CH.sub.3                                                                      H  H  H CH.sub.3                                                                          OCH.sub.3                                                                          CH.sub.3                                                                             N                                             CH  CO.sub.2 CH.sub.3                                                                      CH.sub.3                                                                          CH.sub.3                                                                          H H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH                                            CH  CO.sub.2 CH.sub.3                                                                      CH.sub.3                                                                          CH.sub.3                                                                          H H  OCH.sub.3                                                                          CH.sub.3                                                                             CH                                            CH  CO.sub.2 CH.sub.3                                                                      CH.sub.3                                                                          CH.sub.3                                                                          H H  Cl  OCH.sub.3                                                                            CH                                            CH  CO.sub.2 CH.sub.3                                                                      CH.sub.3                                                                          CH.sub.3                                                                          H H  CH.sub.3                                                                           CH.sub.3                                                                             CH                                            CH  CO.sub.2 CH.sub.3                                                                      CH.sub.3                                                                          CH.sub.3                                                                          H H  OCH.sub.3                                                                          OCH.sub.3                                                                            N                                             CH  CO.sub.2 CH.sub.3                                                                      CH.sub.3                                                                          CH.sub.3                                                                          H H  OCH.sub.3                                                                          CH.sub.3                                                                             N                                             CH  CO.sub.2 CH.sub.3                                                                      CH.sub.3                                                                          CH.sub.3                                                                          H H  OC.sub.2 H.sub.5                                                                   NHCH.sub.3                                                                           N                                             CH  CO.sub.2 CH.sub.3                                                                      CH.sub.3                                                                          CH.sub.3                                                                          H CH.sub.3                                                                          OCH.sub.3                                                                          CH.sub.3                                                                             N                                             CH  CO.sub.2 CH.sub.3                                                                      H  H  H H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH                                            CH  CO.sub.2 CH.sub.3                                                                      H  H  H H  OCH.sub.3                                                                          CH.sub.3                                                                             CH                                            CH  CO.sub.2 CH.sub.3                                                                      H  H  H H  Cl  OCH.sub.3                                                                            CH                                            CH  CO.sub.2 CH.sub.3                                                                      H  H  H H  CH.sub.3                                                                           CH.sub.3                                                                             CH                                            CH  CO.sub.2 CH.sub.3                                                                      H  H  H H  OCH.sub.3                                                                          OCH.sub.3                                                                            N                                             CH  CO.sub.2 CH.sub.3                                                                      H  H  H H  OCH.sub.3                                                                          CH.sub.3                                                                             N                                             CH  CO.sub.2 CH.sub.3                                                                      H  H  H H  OC.sub.2 H.sub.5                                                                   NHCH.sub.3                                                                           N                                             CH  CO.sub.2 CH.sub.3                                                                      H  H  H CH.sub.3                                                                          OCH.sub.3                                                                          CH.sub.3                                                                             N                                             N   CO.sub.2 C.sub.2 H.sub.5                                                               H  H  H H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH                                            N   CO.sub.2 C.sub.2 H.sub.5                                                               H  H  H H  OCH.sub.3                                                                          CH.sub.3                                                                             CH                                            N   CO.sub.2 C.sub.2 H.sub.5                                                               H  H  H H  Cl  OCH.sub.3                                                                            CH                                            N   CO.sub.2 C.sub.2 H.sub.5                                                               H  H  H H  CH.sub.3                                                                           CH.sub.3                                                                             CH                                            N   CO.sub.2 C.sub.2 H.sub.5                                                               H  H  H H  OCH.sub.3                                                                          OCH.sub.3                                                                            N                                             N   CO.sub.2 C.sub.2 H.sub.5                                                               H  H  H H  OCH.sub.3                                                                          CH.sub.3                                                                             N                                             N   CO.sub.2 C.sub.2 H.sub.5                                                               H  H  H H  OC.sub.2 H.sub.5                                                                   NHCH.sub.3                                                                           N                                             N   CO.sub.2 C.sub.2 H.sub.5                                                               H  H  H CH.sub.3                                                                          OCH.sub.3                                                                          CH.sub.3                                                                             N                                             N   CO.sub.2 C.sub.2 H.sub.5                                                               CH.sub.3                                                                          CH.sub.3                                                                          H H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH                                            N   CO.sub.2 C.sub.2 H.sub.5                                                               CH.sub.3                                                                          CH.sub.3                                                                          H H  OCH.sub.3                                                                          CH.sub.3                                                                             CH                                            N   CO.sub.2 C.sub.2 H.sub.5                                                               CH.sub.3                                                                          CH.sub.3                                                                          H H  Cl  OCH.sub.3                                                                            CH                                            N   CO.sub.2 C.sub.2 H.sub.5                                                               CH.sub.3                                                                          CH.sub.3                                                                          H H  CH.sub.3                                                                           CH.sub.3                                                                             CH                                            N   CO.sub.2 C.sub.2 H.sub.5                                                               CH.sub.3                                                                          CH.sub.3                                                                          H H  OCH.sub.3                                                                          OCH.sub.3                                                                            N                                             N   CO.sub.2 C.sub.2 H.sub.5                                                               CH.sub.3                                                                          CH.sub.3                                                                          H H  OCH.sub.3                                                                          CH.sub.3                                                                             N                                             N   CO.sub.2 C.sub.2 H.sub.5                                                               CH.sub.3                                                                          CH.sub.3                                                                          H H  OC.sub.2 H.sub.5                                                                   NHCH.sub.3                                                                           N                                             N   CO.sub.2 C.sub.2 H.sub.5                                                               CH.sub.3                                                                          CH.sub.3                                                                          H CH.sub.3                                                                          OCH.sub.3                                                                          CH.sub.3                                                                             N                                             __________________________________________________________________________

                  TABLE 9                                                          ______________________________________                                         General Formula 9                                                              R.sup.1  R.sup.3                                                                              R.sup.5    R    X     Y      Z.sup.4                            ______________________________________                                         H        H     H          H    OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                 H        H     H          H    OCH.sub.3                                                                            CH.sub.3                                                                              CH                                 H        H     H          H    Cl    OCH.sub.3                                                                             CH                                 H        H     H          H    CH.sub.3                                                                             CH.sub.3                                                                              CH                                 H        H     H          H    OCH.sub.3                                                                            OCH.sub.3                                                                             N                                  H        H     H          H    OCH.sub.3                                                                            CH.sub.3                                                                              N                                  H        H     H          H    OC.sub.2 H.sub.5                                                                     NHCH.sub.3                                                                            N                                  H        H     H          CH.sub.3                                                                            OCH.sub.3                                                                            CH.sub.3                                                                              N                                  Cl       H     H          H    OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                 Cl       H     H          H    OCH.sub.3                                                                            CH.sub.3                                                                              CH                                 Cl       H     H          H    Cl    OCH.sub.3                                                                             CH                                 Cl       H     H          H    CH.sub.3                                                                             CH.sub.3                                                                              CH                                 Cl       H     H          H    OCH.sub.3                                                                            OCH.sub.3                                                                             N                                  Cl       H     H          H    OCH.sub.3                                                                            CH.sub.3                                                                              N                                  Cl       H     H          H    OC.sub.2 H.sub.5                                                                     NHCH.sub.3                                                                            N                                  Cl       H     H          CH.sub.3                                                                            OCH.sub.3                                                                            CH.sub.3                                                                              N                                  SO.sub.2 CH.sub.3                                                                       H     H          H    OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                 SO.sub.2 CH.sub.3                                                                       H     H          H    OCH.sub.3                                                                            CH.sub.3                                                                              CH                                 SO.sub.2 CH.sub.3                                                                       H     H          H    Cl    OCH.sub.3                                                                             CH                                 SO.sub.2 CH.sub.3                                                                       H     H          H    CH.sub.3                                                                             CH.sub.3                                                                              CH                                 SO.sub.2 CH.sub.3                                                                       H     H          H    OCH.sub.3                                                                            OCH.sub.3                                                                             N                                  SO.sub.2 CH.sub.3                                                                       H     H          H    OCH.sub.3                                                                            CH.sub.3                                                                              N                                  SO.sub.2 CH.sub.3                                                                       H     H          H    OC.sub.2 H.sub.5                                                                     NHCH.sub.3                                                                            N                                  SO.sub.2 CH.sub.3                                                                       H     H          CH.sub.3                                                                            OCH.sub.3                                                                            CH.sub.3                                                                              N                                  CO.sub.2 CH.sub.3                                                                       H     H          H    OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                 CO.sub.2 CH.sub.3                                                                       H     H          H    OCH.sub.3                                                                            CH.sub.3                                                                              CH                                 CO.sub.2 CH.sub.3                                                                       H     H          H    Cl    OCH.sub.3                                                                             CH                                 CO.sub.2 CH.sub.3                                                                       H     H          H    CH.sub.3                                                                             CH.sub.3                                                                              CH                                 CO.sub.2 CH.sub.3                                                                       H     H          H    OCH.sub.3                                                                            OCH.sub.3                                                                             N                                  CO.sub.2 CH.sub.3                                                                       H     H          H    OCH.sub.3                                                                            CH.sub.3                                                                              N                                  CO.sub.2 CH.sub.3                                                                       H     H          H    OC.sub.2 H.sub.5                                                                     NHCH.sub.3                                                                            N                                  CO.sub.2 CH.sub.3                                                                       H     H          CH.sub.3                                                                            OCH.sub.3                                                                            CH.sub.3                                                                              N                                  CO.sub.2 C.sub.2 H.sub.5                                                                H     H          H    OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                 CO.sub.2 C.sub.2 H.sub.5                                                                H     H          H    OCH.sub.3                                                                            CH.sub.3                                                                              CH                                 CO.sub.2 C.sub.2 H.sub.5                                                                H     H          H    Cl    OCH.sub.3                                                                             CH                                 CO.sub.2 C.sub.2 H.sub.5                                                                H     H          H    CH.sub.3                                                                             CH.sub.3                                                                              CH                                 CO.sub.2 C.sub.2 H.sub.5                                                                H     H          H    OCH.sub.3                                                                            OCH.sub.3                                                                             N                                  CO.sub.2 C.sub.2 H.sub.5                                                                H     H          H    OCH.sub.3                                                                            CH.sub.3                                                                              N                                  CO.sub.2 C.sub.2 H.sub.5                                                                H     H          H    OC.sub.2 H.sub.5                                                                     NHCH.sub.3                                                                            N                                  CO.sub.2 C.sub.2 H.sub.5                                                                H     H          CH.sub.3                                                                            OCH.sub.3                                                                            CH.sub.3                                                                              N                                  SO.sub.2 N(CH.sub.3).sub.2                                                              H     H          H    OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                 SO.sub.2 N(CH.sub.3).sub.2                                                              H     H          H    OCH.sub.3                                                                            CH.sub.3                                                                              CH                                 SO.sub.2 N(CH.sub.3).sub.2                                                              H     H          H    Cl    OCH.sub.3                                                                             CH                                 SO.sub.2 N(CH.sub.3).sub.2                                                              H     H          H    CH.sub.3                                                                             CH.sub.3                                                                              CH                                 SO.sub.2 N(CH.sub.3).sub.2                                                              H     H          H    OCH.sub.3                                                                            OCH.sub.3                                                                             N                                  SO.sub.2 N(CH.sub.3).sub.2                                                              H     H          H    OCH.sub.3                                                                            CH.sub.3                                                                              N                                  SO.sub.2 N(CH.sub.3).sub.2                                                              H     H          H    OC.sub.2 H.sub.5                                                                     NHCH.sub.3                                                                            N                                  SO.sub.2 N(CH.sub.3).sub.2                                                              H     H          CH.sub. 3                                                                           OCH.sub.3                                                                            CH.sub.3                                                                              N                                  H        H     H          H    OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                 H        H     H          H    OCH.sub.3                                                                            CH.sub.3                                                                              CH                                 H        H     H          H    Cl    OCH.sub.3                                                                             CH                                 H        H     H          H    CH.sub.3                                                                             CH.sub.3                                                                              CH                                 H        H     H          H    OCH.sub.3                                                                            OCH.sub.3                                                                             N                                  H        H     H          H    OCH.sub.3                                                                            CH.sub.3                                                                              N                                  H        H     H          H    OC.sub.2 H.sub.5                                                                     NHCH.sub.3                                                                            N                                  H        H     H          CH.sub.3                                                                            OCH.sub.3                                                                            CH.sub.3                                                                              N                                  H        H     Cl         H    OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                 H        H     Cl         H    OCH.sub.3                                                                            CH.sub.3                                                                              CH                                 H        H     Cl         H    Cl    OCH.sub.3                                                                             CH                                 H        H     Cl         H    CH.sub.3                                                                             CH.sub.3                                                                              CH                                 H        H     Cl         H    OCH.sub.3                                                                            OCH.sub.3                                                                             N                                  H        H     Cl         H    OCH.sub.3                                                                            CH.sub.3                                                                              N                                  H        H     Cl         H    OC.sub.2 H.sub.5                                                                     NHCH.sub.3                                                                            N                                  H        H     Cl         CH.sub.3                                                                            OCH.sub.3                                                                            CH.sub.3                                                                              N                                  H        H     SO.sub.2 CH.sub.3                                                                         H    OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                 H        H     SO.sub.2 CH.sub.3                                                                         H    OCH.sub.3                                                                            CH.sub.3                                                                              CH                                 H        H     SO.sub.2 CH.sub.3                                                                         H    Cl    OCH.sub.3                                                                             CH                                 H        H     SO.sub.2 CH.sub.3                                                                         H    CH.sub.3                                                                             CH.sub.3                                                                              CH                                 H        H     SO.sub.2 CH.sub.3                                                                         H    OCH.sub.3                                                                            OCH.sub.3                                                                             N                                  H        H     SO.sub.2 CH.sub.3                                                                         H    OCH.sub.3                                                                            CH.sub.3                                                                              N                                  H        H     SO.sub.2 CH.sub.3                                                                         H    OC.sub.2 H.sub.5                                                                     NHCH.sub.3                                                                            N                                  H        H     SO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                            OCH.sub.3                                                                            CH.sub.3                                                                              N                                  H        H     CO.sub.2 CH.sub.3                                                                         H    OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                 H        H     CO.sub.2 CH.sub.3                                                                         H    OCH.sub.3                                                                            CH.sub.3                                                                              CH                                 H        H     CO.sub.2 CH.sub.3                                                                         H    Cl    OCH.sub.3                                                                             CH                                 H        H     CO.sub.2 CH.sub.3                                                                         H    CH.sub.3                                                                             CH.sub.3                                                                              CH                                 H        H     CO.sub.2 CH.sub.3                                                                         H    OCH.sub.3                                                                            OCH.sub.3                                                                             N                                  H        H     CO.sub.2 CH.sub.3                                                                         H    OCH.sub.3                                                                            CH.sub.3                                                                              N                                  H        H     CO.sub.2 CH.sub.3                                                                         H    OC.sub.2 H.sub.5                                                                     NHCH.sub.3                                                                            N                                  H        H     CO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                            OCH.sub.3                                                                            CH.sub.3                                                                              N                                  H        H     CO.sub.2 C.sub.2 H.sub.5                                                                  H    OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                 H        H     CO.sub.2 C.sub.2 H.sub.5                                                                  H    OCH.sub.3                                                                            CH.sub.3                                                                              CH                                 H        H     CO.sub.2 C.sub.2 H.sub.5                                                                  H    Cl    OCH.sub.3                                                                             CH                                 H        H     CO.sub.2 C.sub.2 H.sub.5                                                                  H    CH.sub.3                                                                             CH.sub.3                                                                              CH                                 H        H     CO.sub.2 C.sub.2 H.sub.5                                                                  H    OCH.sub.3                                                                            OCH.sub.3                                                                             N                                  H        H     CO.sub.2 C.sub.2 H.sub.5                                                                  H    OCH.sub.3                                                                            CH.sub.3                                                                              N                                  H        H     CO.sub.2 C.sub.2 H.sub.5                                                                  H    OC.sub.2 H.sub.5                                                                     NHCH.sub.3                                                                            N                                  H        H     CO.sub.2 C.sub.2 H.sub.5                                                                  CH.sub.3                                                                            OCH.sub.3                                                                            CH.sub.3                                                                              N                                  H        H     SO.sub.2 N(CH.sub.3).sub.2                                                                H    OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                 H        H     SO.sub.2 N(CH.sub.3).sub.2                                                                H    OCH.sub.3                                                                            CH.sub.3                                                                              CH                                 H        H     SO.sub.2 N(CH.sub.3).sub.2                                                                H    Cl    OCH.sub.3                                                                             CH                                 H        H     SO.sub.2 N(CH.sub.3).sub.2                                                                H    CH.sub.3                                                                             CH.sub.3                                                                              CH                                 H        H     SO.sub.2 N(CH.sub.3).sub.2                                                                H    OCH.sub.3                                                                            OCH.sub.3                                                                             N                                  H        H     SO.sub.2 N(CH.sub.3).sub.2                                                                H    OCH.sub.3                                                                            CH.sub.3                                                                              N                                  H        H     SO.sub.2 N(CH.sub.3).sub.2                                                                H    OC.sub.2 H.sub.5                                                                     NHCH.sub.3                                                                            N                                  H        H     SO.sub.2 N(CH.sub.3).sub.2                                                                CH.sub.3                                                                            OCH.sub.3                                                                            CH.sub.3                                                                              N                                  ______________________________________                                    

                  TABLE 10                                                         ______________________________________                                         General Formula 10                                                             Z    R.sup.2                                                                              R.sup.3                                                                               R.sup.5  R    X      Y      Z.sup.4                          ______________________________________                                         CH   H     H      H        H    OCH.sub.3                                                                             OCH.sub.3                                                                             CH                               CH   H     H      H        H    OCH.sub.3                                                                             CH.sub.3                                                                              CH                               CH   H     H      H        H    Cl     OCH.sub.3                                                                             CH                               CH   H     H      H        H    CH.sub.3                                                                              CH.sub.3                                                                              CH                               CH   H     H      H        H    OCH.sub.3                                                                             OCH.sub.3                                                                             N                                CH   H     H      H        H    OCH.sub.3                                                                             CH.sub.3                                                                              N                                CH   H     H      H        H    OC.sub.2 H.sub.5                                                                      NHCH.sub.3                                                                            N                                CH   H     H      H        CH.sub.3                                                                            OCH.sub.3                                                                             CH     N                                CH   H     H      Cl       H    OCH.sub.3                                                                             OCH.sub.3                                                                             CH                               CH   H     H      Cl       H    OCH.sub.3                                                                             CH.sub.3                                                                              CH                               CH   H     H      Cl       H    Cl     OCH.sub.3                                                                             CH                               CH   H     H      Cl       H    CH.sub.3                                                                              CH.sub.3                                                                              CH                               CH   H     H      Cl       H    OCH.sub.3                                                                             OCH.sub.3                                                                             N                                CH   H     H      Cl       H    OCH.sub.3                                                                             CH.sub.3                                                                              N                                CH   H     H      Cl       H    OC.sub.2 H.sub.5                                                                      NHCH.sub.3                                                                            N                                CH   H     H      Cl       CH.sub.3                                                                            OCH.sub.3                                                                             CH     N                                CH   H     H      SO.sub.2 CH.sub.3                                                                       H    OCH.sub.3                                                                             OCH.sub.3                                                                             CH                               CH   H     H      SO.sub.2 CH.sub.3                                                                       H    OCH.sub.3                                                                             CH.sub.3                                                                              CH                               CH   H     H      SO.sub.2 CH.sub.3                                                                       H    Cl     OCH.sub.3                                                                             CH                               CH   H     H      SO.sub.2 CH.sub.3                                                                       H    CH.sub.3                                                                              CH.sub.3                                                                              CH                               CH   H     H      SO.sub.2 CH.sub.3                                                                       H    OCH.sub.3                                                                             OCH.sub.3                                                                             N                                CH   H     H      SO.sub.2 CH.sub.3                                                                       H    OCH.sub.3                                                                             CH.sub.3                                                                              N                                CH   H     H      SO.sub.2 CH.sub.3                                                                       H    OC.sub.2 H.sub.5                                                                      NHCH.sub.3                                                                            N                                CH   H     H      SO.sub.2 CH.sub.3                                                                       CH.sub.3                                                                            OCH.sub.3                                                                             CH.sub.3                                                                              N                                N    H     H      H        H    OCH.sub.3                                                                             OCH.sub.3                                                                             CH                               N    H     H      H        H    OCH.sub.3                                                                             CH.sub.3                                                                              CH                               N    H     H      H        H    Cl     OCH.sub.3                                                                             CH                               N    H     H      H        H    CH.sub.3                                                                              CH.sub.3                                                                              CH                               N    H     H      H        H    OCH.sub.3                                                                             OCH.sub.3                                                                             N                                N    H     H      H        H    OCH.sub.3                                                                             CH.sub.3                                                                              N                                N    H     H      H        H    OC.sub.2 H.sub.5                                                                      NHCH.sub.3                                                                            N                                N    H     H      CH.sub.3 H    OCH.sub.3                                                                             CH.sub.3                                                                              N                                N    H     H      Cl       H    OCH.sub.3                                                                             OCH.sub.3                                                                             CH                               N    H     H      Cl       H    OCH.sub.3                                                                             CH.sub.3                                                                              CH                               N    H     H      Cl       H    Cl     OCH.sub.3                                                                             CH                               N    H     H      Cl       H    CH.sub.3                                                                              CH.sub.3                                                                              CH                               N    H     H      Cl       H    OCH.sub.3                                                                             OCH.sub.3                                                                             N                                N    H     H      Cl       H    OCH.sub.3                                                                             CH.sub.3                                                                              N                                N    H     H      Cl       H    OC.sub.2 H.sub.5                                                                      NHCH.sub.3                                                                            N                                N    H     H      Cl       CH.sub.3                                                                            OCH.sub.3                                                                             CH.sub.3                                                                              N                                N    H     H      SO.sub.2 CH.sub.3                                                                       H    OCH.sub.3                                                                             OCH.sub.3                                                                             CH                               N    H     H      SO.sub.2 CH.sub.3                                                                       H    OCH.sub.3                                                                             CH.sub.3                                                                              CH                               N    H     H      SO.sub.2 CH.sub.3                                                                       H    Cl     OCH.sub.3                                                                             CH                               N    H     H      SO.sub.2 CH.sub.3                                                                       H    CH.sub.3                                                                              CH.sub.3                                                                              CH                               N    H     H      SO.sub.2 CH.sub.3                                                                       H    OCH.sub.3                                                                             OCH.sub.3                                                                             N                                N    H     H      SO.sub.2 CH.sub.3                                                                       H    OCH.sub.3                                                                             CH.sub.3                                                                              N                                N    H     H      SO.sub.2 CH.sub.3                                                                       H    OC.sub.2 H.sub.5                                                                      NHCH.sub.3                                                                            N                                N    H     H      SO.sub.2 CH.sub.3                                                                       CH.sub.3                                                                            OCH.sub.3                                                                             CH.sub.3                                                                              N                                CH   H     H      CO.sub.2 CH.sub.3                                                                       H    OCH.sub.3                                                                             OCH.sub.3                                                                             CH                               CH   H     H      CO.sub.2 CH.sub.3                                                                       H    OCH.sub.3                                                                             CH.sub.3                                                                              CH                               CH   H     H      CO.sub.2 CH.sub.3                                                                       H    Cl     OCH.sub.3                                                                             CH                               CH   H     H      CO.sub.2 CH.sub.3                                                                       H    CH.sub.3                                                                              CH.sub.3                                                                              CH                               CH   H     H      CO.sub.2 CH.sub.3                                                                       H    OCH.sub.3                                                                             OCH.sub.3                                                                             N                                CH   H     H      CO.sub.2 CH.sub.3                                                                       H    OCH.sub.3                                                                             CH.sub.3                                                                              N                                CH   H     H      CO.sub.2 CH.sub.3                                                                       H    OC.sub.2 H.sub.5                                                                      NHCH.sub.3                                                                            N                                CH   H     H      CO.sub.2 CH.sub.3                                                                       CH.sub.3                                                                            OCH.sub.3                                                                             CH.sub.3                                                                              N                                CH   H     H      CO.sub.2 C.sub.2 H.sub.5                                                                H    OCH.sub.3                                                                             OCH.sub.3                                                                             CH                               CH   H     H      CO.sub.2 C.sub.2 H.sub.5                                                                H    OCH.sub.3                                                                             CH.sub.3                                                                              CH                               CH   H     H      CO.sub.2 C.sub.2 H.sub.5                                                                H    Cl     OCH.sub.3                                                                             CH                               CH   H     H      CO.sub.2 C.sub.2 H.sub.5                                                                H    CH.sub.3                                                                              CH.sub.3                                                                              CH                               CH   H     H      CO.sub.2 C.sub.2 H.sub.5                                                                H    OCH.sub.3                                                                             OCH.sub.3                                                                             N                                CH   H     H      CO.sub.2 C.sub.2 H.sub.5                                                                H    OCH.sub.3                                                                             CH.sub.3                                                                              N                                CH   H     H      CO.sub.2 C.sub.2 H.sub.5                                                                H    OC.sub.2 H.sub.5                                                                      NHCH.sub.3                                                                            N                                CH   H     H      CO.sub.2 C.sub.2 H.sub.5                                                                CH.sub.3                                                                            OCH.sub.3                                                                             CH.sub.3                                                                              N                                CH   H     H      SO.sub.2 N(CH.sub.3).sub.2                                                              H    OCH.sub.3                                                                             OCH.sub.3                                                                             CH                               CH   H     H      SO.sub.2 N(CH.sub.3).sub.2                                                              H    OCH.sub.3                                                                             CH.sub.3                                                                              CH                               CH   H     H      SO.sub.2 N(CH.sub.3).sub.2                                                              H    Cl     OCH.sub.3                                                                             CH                               CH   H     H      SO.sub.2 N(CH.sub.3).sub.2                                                              H    CH.sub.3                                                                              CH.sub.3                                                                              CH                               CH   H     H      SO.sub.2 N(CH.sub.3).sub.2                                                              H    OCH.sub.3                                                                             OCH.sub.3                                                                             N                                CH   H     H      SO.sub.2 N(CH.sub.3).sub.2                                                              H    OCH.sub.3                                                                             CH.sub.3                                                                              N                                CH   H     H      SO.sub.2 N(CH.sub.3).sub.2                                                              H    OC.sub.2 H.sub.5                                                                      NHCH.sub.3                                                                            N                                CH   H     H      SO.sub.2 N(CH.sub.3).sub.2                                                              CH.sub.3                                                                            OCH.sub.3                                                                             CH.sub.3                                                                              N                                N    H     H      CO.sub.2 CH.sub.3                                                                       H    OCH.sub.3                                                                             OCH.sub.3                                                                             CH                               N    H     H      CO.sub.2 CH.sub.3                                                                       H    OCH.sub.3                                                                             CH.sub.3                                                                              CH                               N    H     H      CO.sub.2 CH.sub.3                                                                       H    Cl     OCH.sub.3                                                                             CH                               N    H     H      CO.sub.2 CH.sub.3                                                                       H    CH.sub.3                                                                              CH.sub.3                                                                              CH                               N    H     H      CO.sub.2 CH.sub.3                                                                       H    OCH.sub.3                                                                             OCH.sub.3                                                                             N                                N    H     H      CO.sub.2 CH.sub.3                                                                       H    OCH.sub.3                                                                             CH.sub.3                                                                              N                                N    H     H      CO.sub.2 CH.sub.3                                                                       H    OC.sub.2 H.sub.5                                                                      NHCH.sub.3                                                                            N                                N    H     H      CO.sub.2 CH.sub.3                                                                       CH.sub.3                                                                            OCH.sub.3                                                                             CH.sub.3                                                                              N                                N    H     H      CO.sub.2 C.sub.2 H.sub.5                                                                H    OCH.sub.3                                                                             OCH.sub.3                                                                             CH                               N    H     H      CO.sub.2 C.sub.2 H.sub.5                                                                H    OCH.sub.3                                                                             CH.sub.3                                                                              CH                               N    H     H      CO.sub.2 C.sub.2 H.sub.5                                                                H    Cl     OCH.sub.3                                                                             CH                               N    H     H      CO.sub.2 C.sub.2 H.sub.5                                                                H    CH.sub.3                                                                              CH.sub.3                                                                              CH                               N    H     H      CO.sub.2 C.sub.2 H.sub.5                                                                H    OCH.sub.3                                                                             OCH.sub.3                                                                             N                                N    H     H      CO.sub.2 C.sub.2 H.sub.5                                                                H    OCH.sub.3                                                                             CH.sub.3                                                                              N                                N    H     H      CO.sub.2 C.sub.2 H.sub.5                                                                H    OC.sub.2 H.sub.5                                                                      NHCH.sub.3                                                                            N                                N    H     H      CO.sub.2 C.sub.2 H.sub.5                                                                CH.sub.3                                                                            OCH.sub.3                                                                             CH.sub.3                                                                              N                                N    H     H      SO.sub.2 N(CH.sub.3).sub.2                                                              H    OCH.sub. 3                                                                            OCH.sub.3                                                                             CH                               N    H     H      SO.sub.2 N(CH.sub.3).sub.2                                                              H    OCH.sub.3                                                                             CH.sub.3                                                                              CH                               N    H     H      SO.sub.2 N(CH.sub.3).sub.2                                                              H    Cl     OCH.sub.3                                                                             CH                               N    H     H      SO.sub.2 N(CH.sub.3).sub.2                                                              H    CH.sub.3                                                                              CH.sub.3                                                                              CH                               N    H     H      SO.sub.2 N(CH.sub.3).sub.2                                                              H    OCH.sub.3                                                                             OCH.sub.3                                                                             N                                N    H     H      SO.sub.2 N(CH.sub.3).sub.2                                                              H    OCH.sub.3                                                                             CH.sub.3                                                                              N                                N    H     H      SO.sub.2 N(CH.sub.3).sub.2                                                              H    OC.sub.2 H.sub.5                                                                      NHCH.sub.3                                                                            N                                N    H     H      SO.sub.2 N(CH.sub.3).sub.2                                                              CH.sub.3                                                                            OCH.sub.3                                                                             CH.sub.3                                                                              N                                ______________________________________                                    

                  TABLE 11                                                         ______________________________________                                         General Formula 11                                                                                                         M.P.                               R.sup.3                                                                            R.sup.5     R       X      Y       Z.sup.4                                                                             (°C.)                       ______________________________________                                         H   H           H       OCH.sub.3                                                                             OCH.sub.3                                                                              CH                                      H   H           H       OCH.sub.3                                                                             CH.sub.3                                                                               CH                                      H   H           H       Cl     OCH.sub.3                                                                              CH                                      H   H           H       CH.sub.3                                                                              CH.sub.3                                                                               CH                                      H   H           H       OCH.sub.3                                                                             OCH.sub.3                                                                              N                                       H   H           H       OCH.sub.3                                                                             CH.sub.3                                                                               N                                       H   H           H       OC.sub.2 H.sub.5                                                                      NHCH.sub.3                                                                             N                                       H   H           CH.sub.3                                                                               OCH.sub.3                                                                             CH.sub.3                                                                               N                                       H   Cl          H       OCH.sub.3                                                                             OCH.sub.3                                                                              CH                                      H   Cl          H       OCH.sub.3                                                                             CH.sub.3                                                                               CH                                      H   Cl          H       Cl     OCH.sub.3                                                                              CH                                      H   Cl          H       CH.sub.3                                                                              CH.sub.3                                                                               CH                                      H   Cl          H       OCH.sub.3                                                                             OCH.sub.3                                                                              N                                       H   Cl          H       OCH.sub.3                                                                             CH.sub.3                                                                               N                                       H   Cl          H       OC.sub.2 H.sub.5                                                                      NHCH.sub.3                                                                             N                                       H   Cl          CH.sub.3                                                                               OCH.sub.3                                                                             CH.sub.3                                                                               N                                       H   SO.sub.2 CH.sub.3                                                                          H       OCH.sub.3                                                                             OCH.sub.3                                                                              CH                                      H   SO.sub.2 CH.sub.3                                                                          H       OCH.sub.3                                                                             CH.sub.3                                                                               CH                                      H   SO.sub.2 CH.sub. 3                                                                         H       Cl     OCH.sub.3                                                                              CH                                      H   SO.sub.2 CH.sub.3                                                                          H       CH.sub.3                                                                              CH.sub.3                                                                               CH                                      H   SO.sub.2 CH.sub.3                                                                          H       OCH.sub.3                                                                             OCH.sub.3                                                                              N                                       H   SO.sub.2 CH.sub.3                                                                          H       OCH.sub.3                                                                             CH.sub.3                                                                               N                                       H   SO.sub.2 CH.sub.3                                                                          H       OC.sub.2 H.sub.5                                                                      NHCH.sub.3                                                                             N                                       H   SO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                               OCH.sub.3                                                                             CH.sub.3                                                                               N                                       H   CO.sub.2 CH.sub.3                                                                          H       OCH.sub.3                                                                             OCH.sub.3                                                                              CH                                      H   CO.sub.2 CH.sub.3                                                                          H       OCH.sub.3                                                                             CH.sub.3                                                                               CH                                      H   CO.sub.2 CH.sub.3                                                                          H       Cl     OCH.sub.3                                                                              CH                                      H   CO.sub.2 CH.sub.3                                                                          H       CH.sub.3                                                                              CH.sub.3                                                                               CH                                      H   CO.sub.2 CH.sub.3                                                                          H       OCH.sub.3                                                                             OCH.sub.3                                                                              N                                       H   CO.sub.2 CH.sub.3                                                                          H       OCH.sub.3                                                                             CH.sub.3                                                                               N                                       H   CO.sub.2 CH.sub.3                                                                          H       OC.sub.2 H.sub.5                                                                      NHCH.sub.3                                                                             N                                       H   CO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                               OCH.sub.3                                                                             CH.sub.3                                                                               N                                       H   CO.sub.2 C.sub.2 H.sub.5                                                                   H       OCH.sub.3                                                                             OCH.sub.3                                                                              CH                                      H   CO.sub.2 C.sub.2 H.sub.5                                                                   H       OCH.sub.3                                                                             CH.sub.3                                                                               CH                                      H   CO.sub.2 C.sub.2 H.sub.5                                                                   H       Cl     OCH.sub.3                                                                              CH                                      H   CO.sub.2 C.sub.2 H.sub.5                                                                   H       CH.sub.3                                                                              CH.sub.3                                                                               CH                                      H   CO.sub.2 C.sub.2 H.sub.5                                                                   H       OCH.sub.3                                                                             OCH.sub.3                                                                              N                                       H   CO.sub.2 C.sub.2 H.sub.5                                                                   H       OCH.sub.3                                                                             CH.sub.3                                                                               N                                       H   CO.sub.2 C.sub.2 H.sub.5                                                                   H       OC.sub.2 H.sub.5                                                                      NHCH.sub.3                                                                             N                                       H   CO.sub.2 C.sub.2 H.sub.5                                                                   CH.sub.3                                                                               OCH.sub.3                                                                             CH.sub.3                                                                               N                                       H   SO.sub.2 N(CH.sub.3).sub.2                                                                 H       OCH.sub.3                                                                             OCH.sub.3                                                                              CH                                      H   SO.sub.2 N(CH.sub.3).sub.2                                                                 H       OCH.sub.3                                                                             CH.sub.3                                                                               CH                                      H   SO.sub.2 N(CH.sub.3).sub.2                                                                 H       Cl     OCH.sub.3                                                                              CH                                      H   SO.sub.2 N(CH.sub.3).sub.2                                                                 H       CH.sub.3                                                                              CH.sub.3                                                                               CH                                      H   SO.sub.2 N(CH.sub.3).sub.2                                                                 H       OCH.sub.3                                                                             OCH.sub.3                                                                              N                                       H   SO.sub.2 N(CH.sub.3).sub.2                                                                 H       OCH.sub.3                                                                             CH.sub.3                                                                               N                                       H   SO.sub.2 N(CH.sub.3).sub.2                                                                 H       OC.sub.2 H.sub.5                                                                      NHCH.sub.3                                                                             N                                       H   SO.sub.2 N(CH.sub.3).sub.2                                                                 CH.sub.3                                                                               OCH.sub.3                                                                             CH.sub.3                                                                               N                                       ______________________________________                                    

                  TABLE 12                                                         ______________________________________                                         R.sup.1  R.sup.2                                                                               R.sup.4                                                                               R     X      Y       Z.sup.4                            ______________________________________                                         H        H      H      H     OCH.sub.3                                                                             OCH.sub.3                                                                              CH                                 H        H      H      H     OCH.sub.3                                                                             CH.sub.3                                                                               CH                                 H        H      H      H     Cl     OCH.sub.3                                                                              CH                                 H        H      H      H     CH.sub.3                                                                              CH.sub.3                                                                               CH                                 H        H      H      H     OCH.sub.3                                                                             OCH.sub.3                                                                              N                                  H        H      H      H     OCH.sub.3                                                                             CH.sub.3                                                                               N                                  H        H      H      H     OC.sub.2 H.sub.5                                                                      NHCH.sub.3                                                                             N                                  H        H      H      CH.sub.3                                                                             OCH.sub.3                                                                             CH.sub.3                                                                               N                                  Cl       H      H      H     OCH.sub.3                                                                             OCH.sub.3                                                                              CH                                 Cl       H      H      H     OCH.sub.3                                                                             CH.sub.3                                                                               CH                                 Cl       H      H      H     Cl     OCH.sub.3                                                                              CH                                 Cl       H      H      H     CH.sub.3                                                                              CH.sub.3                                                                               CH                                 Cl       H      H      H     OCH.sub.3                                                                             OCH.sub.3                                                                              N                                  Cl       H      H      H     OCH.sub.3                                                                             CH.sub.3                                                                               N                                  Cl       H      H      H     OC.sub.2 H.sub.5                                                                      NHCH.sub.3                                                                             N                                  Cl       H      H      CH.sub.3                                                                             OCH.sub.3                                                                             CH.sub.3                                                                               N                                  SO.sub.2 CH.sub.3                                                                       H      H      H     OCH.sub.3                                                                             OCH.sub.3                                                                              CH                                 SO.sub.2 CH.sub.3                                                                       H      H      H     OCH.sub.3                                                                             CH.sub.3                                                                               CH                                 SO.sub.2 CH.sub.3                                                                       H      H      H     Cl     OCH.sub.3                                                                              CH                                 SO.sub.2 CH.sub.3                                                                       H      H      H     CH.sub.3                                                                              CH.sub.3                                                                               CH                                 SO.sub.2 CH.sub.3                                                                       H      H      H     OCH.sub.3                                                                             OCH.sub.3                                                                              N                                  SO.sub.2 CH.sub.3                                                                       H      H      H     OCH.sub.3                                                                             CH.sub.3                                                                               N                                  SO.sub.2 CH.sub.3                                                                       H      H      H     OC.sub.2 H.sub.5                                                                      NHCH.sub.3                                                                             N                                  SO.sub.2 CH.sub.3                                                                       H      H      CH.sub.3                                                                             OCH.sub.3                                                                             CH.sub.3                                                                               N                                  CO.sub.2 CH.sub.3                                                                       H      H      H     OCH.sub.3                                                                             OCH.sub.3                                                                              CH                                 CO.sub.2 CH.sub.3                                                                       H      H      H     OCH.sub.3                                                                             CH.sub.3                                                                               CH                                 CO.sub.2 CH.sub.3                                                                       H      H      H     Cl     OCH.sub.3                                                                              CH                                 CO.sub.2 CH.sub.3                                                                       H      H      H     CH.sub.3                                                                              CH.sub.3                                                                               CH                                 CO.sub.2 CH.sub.3                                                                       H      H      H     OCH.sub.3                                                                             OCH.sub.3                                                                              N                                  CO.sub.2 CH.sub.3                                                                       H      H      H     OCH.sub.3                                                                             CH.sub.3                                                                               N                                  CO.sub.2 CH.sub.3                                                                       H      H      H     OC.sub.2 H.sub.5                                                                      NHCH.sub.3                                                                             N                                  CO.sub.2 CH.sub.3                                                                       H      H      CH.sub.3                                                                             OCH.sub.3                                                                             CH.sub.3                                                                               N                                  CO.sub.2 C.sub.2 H.sub.5                                                                H      H      H     OCH.sub.3                                                                             OCH.sub.3                                                                              CH                                 CO.sub.2 C.sub.2 H.sub.5                                                                H      H      H     OCH.sub.3                                                                             CH.sub.3                                                                               CH                                 CO.sub.2 C.sub.2 H.sub.5                                                                H      H      H     Cl     OCH.sub.3                                                                              CH                                 CO.sub.2 C.sub.2 H.sub.5                                                                H      H      H     CH.sub.3                                                                              CH.sub.3                                                                               CH                                 CO.sub.2 C.sub.2 H.sub.5                                                                H      H      H     OCH.sub.3                                                                             OCH.sub.3                                                                              N                                  CO.sub.2 C.sub.2 H.sub.5                                                                H      H      H     OCH.sub.3                                                                             CH.sub.3                                                                               N                                  CO.sub.2 C.sub.2 H.sub.5                                                                H      H      H     OC.sub.2 H.sub.5                                                                      NHCH.sub.3                                                                             N                                  CO.sub.2 C.sub.2 H.sub.5                                                                H      H      CH.sub.3                                                                             OCH.sub.3                                                                             CH.sub.3                                                                               N                                  SO.sub.2 N(CH.sub.3).sub.2                                                              H      H      H     OCH.sub.3                                                                             OCH.sub.3                                                                              CH                                 SO.sub.2 N(CH.sub.3).sub.2                                                              H      H      H     OCH.sub.3                                                                             CH.sub.3                                                                               CH                                 SO.sub.2 N(CH.sub.3).sub.2                                                              H      H      H     Cl     OCH.sub.3                                                                              CH                                 SO.sub.2 N(CH.sub.3).sub.2                                                              H      H      H     CH.sub.3                                                                              CH.sub.3                                                                               CH                                 SO.sub.2 N(CH.sub.3).sub.2                                                              H      H      H     OCH.sub.3                                                                             OCH.sub.3                                                                              N                                  SO.sub.2 N(CH.sub.3).sub.2                                                              H      H      H     OCH.sub.3                                                                             CH.sub.3                                                                               N                                  SO.sub.2 N(CH.sub.3).sub.2                                                              H      H      H     OC.sub.2 H.sub.5                                                                      NHCH.sub.3                                                                             N                                  SO.sub.2 N(CH.sub.3).sub.2                                                              H      H      CH.sub.3                                                                             OCH.sub. 3                                                                            CH.sub.3                                                                               N                                  ______________________________________                                    

                  TABLE 13                                                         ______________________________________                                         General Formula 13                                                             R.sup.2  R.sup.4                                                                               R        X      Y       Z.sup.4                                ______________________________________                                         H        H      H        OCH.sub.3                                                                             OCH.sub.3                                                                              CH                                     H        H      H        OCH.sub.3                                                                             CH.sub.3                                                                               CH                                     H        H      H        Cl     OCH.sub.3                                                                              CH                                     H        H      H        CH.sub.3                                                                              CH.sub.3                                                                               CH                                     H        H      H        OCH.sub.3                                                                             OCH.sub.3                                                                              N                                      H        H      H        OCH.sub.3                                                                             CH.sub.3                                                                               N                                      H        H      H        OC.sub.2 H.sub.5                                                                      NHCH.sub.3                                                                             N                                      H        H      CH.sub.3 OCH.sub.3                                                                             CH.sub.3                                                                               N                                      CH.sub.3 H      H        OCH.sub.3                                                                             OCH.sub.3                                                                              CH                                     CH.sub.3 H      H        OCH.sub.3                                                                             CH.sub.3                                                                               CH                                     CH.sub.3 H      H        Cl     OCH.sub.3                                                                              CH                                     CH.sub.3 H      H        CH.sub.3                                                                              CH.sub.3                                                                               CH                                     CH.sub.3 H      H        OCH.sub.3                                                                             OCH.sub.3                                                                              N                                      CH.sub.3 H      H        OCH.sub.3                                                                             CH.sub.3                                                                               N                                      CH.sub.3 H      H        OC.sub.2 H.sub.5                                                                      NHCH.sub.3                                                                             N                                      CH.sub.3 H      CH.sub.3 OCH.sub.3                                                                             CH.sub.3                                                                               N                                      OCH.sub.3                                                                               H      H        OCH.sub.3                                                                             OCH.sub.3                                                                              CH                                     OCH.sub.3                                                                               H      H        OCH.sub.3                                                                             CH.sub.3                                                                               CH                                     OCH.sub.3                                                                               H      H        Cl     OCH.sub.3                                                                              CH                                     OCH.sub.3                                                                               H      H        CH.sub.3                                                                              CH.sub.3                                                                               CH                                     OCH.sub.3                                                                               H      H        OCH.sub.3                                                                             OCH.sub.3                                                                              N                                      OCH.sub.3                                                                               H      H        OCH.sub.3                                                                             CH.sub.3                                                                               N                                      OCH.sub.3                                                                               H      H        OC.sub.2 H.sub.5                                                                      NHCH.sub.3                                                                             N                                      OCH.sub.3                                                                               H      CH       OCH.sub.3                                                                             CH.sub.3                                                                               N                                      ______________________________________                                    

                  TABLE 14                                                         ______________________________________                                         General Formula 14                                                             R.sup.1  R.sup.2                                                                               R.sup.4                                                                               R     X      Y       Z.sup.4                            ______________________________________                                         H        H      H      H     OCH.sub.3                                                                             OCH.sub.3                                                                              CH                                 H        H      H      H     OCH.sub.3                                                                             CH.sub.3                                                                               CH                                 H        H      H      H     Cl     OCH.sub.3                                                                              CH                                 H        H      H      H     CH.sub.3                                                                              CH.sub.3                                                                               CH                                 H        H      H      H     OCH.sub.3                                                                             OCH.sub.3                                                                              N                                  H        H      H      H     OCH.sub.3                                                                             CH.sub.3                                                                               N                                  H        H      H      H     OC.sub.2 H.sub.5                                                                      NHCH.sub.3                                                                             N                                  H        H      H      CH.sub.3                                                                             OCH.sub.3                                                                             CH.sub.3                                                                               N                                  Cl       H      H      H     OCH.sub.3                                                                             OCH.sub.3                                                                              CH                                 Cl       H      H      H     OCH.sub.3                                                                             CH.sub.3                                                                               CH                                 Cl       H      H      H     Cl     OCH.sub.3                                                                              CH                                 Cl       H      H      H     CH.sub.3                                                                              CH.sub.3                                                                               CH                                 Cl       H      H      H     OCH.sub.3                                                                             OCH.sub.3                                                                              N                                  Cl       H      H      H     OCH.sub.3                                                                             CH.sub.3                                                                               N                                  Cl       H      H      H     OC.sub.2 H.sub.5                                                                      NHCH.sub.3                                                                             N                                  Cl       H      H      CH.sub.3                                                                             OCH.sub.3                                                                             CH.sub.3                                                                               N                                  SO.sub.2 CH.sub.3                                                                       H      H      H     OCH.sub.3                                                                             OCH.sub.3                                                                              CH                                 SO.sub.2 CH.sub.3                                                                       H      H      H     OCH.sub.3                                                                             CH.sub.3                                                                               CH                                 SO.sub.2 CH.sub.3                                                                       H      H      H     Cl     OCH.sub.3                                                                              CH                                 SO.sub.2 CH.sub.3                                                                       H      H      H     CH.sub.3                                                                              CH.sub.3                                                                               CH                                 SO.sub.2 CH.sub.3                                                                       H      H      H     OCH.sub.3                                                                             OCH.sub.3                                                                              N                                  SO.sub.2 CH.sub.3                                                                       H      H      H     OCH.sub.3                                                                             CH.sub.3                                                                               N                                  SO.sub.2 CH.sub.3                                                                       H      H      H     OC.sub.2 H.sub.5                                                                      NHCH.sub.3                                                                             N                                  SO.sub.2 CH.sub.3                                                                       H      H      CH.sub.3                                                                             OCH.sub.3                                                                             CH.sub.3                                                                               N                                  CO.sub.2 CH.sub.3                                                                       H      H      H     OCH.sub.3                                                                             OCH.sub.3                                                                              CH                                 CO.sub.2 CH.sub.3                                                                       H      H      H     OCH.sub.3                                                                             CH.sub.3                                                                               CH                                 CO.sub.2 CH.sub.3                                                                       H      H      H     Cl     OCH.sub.3                                                                              CH                                 CO.sub.2 CH.sub.3                                                                       H      H      H     CH.sub.3                                                                              CH.sub.3                                                                               CH                                 CO.sub.2 CH.sub.3                                                                       H      H      H     OCH.sub.3                                                                             OCH.sub.3                                                                              N                                  CO.sub.2 CH.sub.3                                                                       H      H      H     OCH.sub.3                                                                             CH.sub.3                                                                               N                                  CO.sub.2 CH.sub.3                                                                       H      H      H     OC.sub.2 H.sub.5                                                                      NHCH.sub.3                                                                             N                                  CO.sub.2 CH.sub.3                                                                       H      H      CH.sub.3                                                                             OCH.sub.3                                                                             CH.sub.3                                                                               N                                  CO.sub.2 C.sub.2 H.sub.5                                                                H      H      H     OCH.sub.3                                                                             OCH.sub.3                                                                              CH                                 CO.sub.2 C.sub.2 H.sub.5                                                                H      H      H     OCH.sub.3                                                                             CH.sub.3                                                                               CH                                 CO.sub.2 C.sub.2 H.sub.5                                                                H      H      H     Cl     OCH.sub.3                                                                              CH                                 CO.sub.2 C.sub.2 H.sub.5                                                                H      H      H     CH.sub.3                                                                              CH.sub.3                                                                               CH                                 CO.sub.2 C.sub.2 H.sub.5                                                                H      H      H     OCH.sub.3                                                                             OCH.sub.3                                                                              N                                  CO.sub.2 C.sub.2 H.sub.5                                                                H      H      H     OCH.sub.3                                                                             CH.sub.3                                                                               N                                  CO.sub.2 C.sub.2 H.sub.5                                                                H      H      H     OC.sub.2 H.sub.5                                                                      NHCH.sub.3                                                                             N                                  CO.sub.2 C.sub.2 H.sub.5                                                                H      H      CH.sub.3                                                                             OCH.sub.3                                                                             CH.sub.3                                                                               N                                  SO.sub.2 N(CH.sub.3).sub.2                                                              H      H      H     OCH.sub.3                                                                             OCH.sub.3                                                                              CH                                 SO.sub.2 N(CH.sub.3).sub.2                                                              H      H      H     OCH.sub.3                                                                             CH.sub.3                                                                               CH                                 SO.sub.2 N(CH.sub.3).sub.2                                                              H      H      H     Cl     OCH.sub.3                                                                              CH                                 SO.sub.2 N(CH.sub.3).sub.2                                                              H      H      H     CH.sub.3                                                                              CH.sub.3                                                                               CH                                 SO.sub.2 N(CH.sub.3).sub.2                                                              H      H      H     OCH.sub.3                                                                             OCH.sub.3                                                                              N                                  SO.sub.2 N(CH.sub.3).sub.2                                                              H      H      H     OCH.sub.3                                                                             CH.sub.3                                                                               N                                  SO.sub.2 N(CH.sub.3).sub.2                                                              H      H      H     OC.sub.2 H.sub.5                                                                      NHCH.sub.3                                                                             N                                  SO.sub.2 N(CH.sub.3).sub.2                                                              H      H      CH.sub.3                                                                             OCH.sub.3                                                                             CH.sub.3                                                                               N                                  ______________________________________                                    

                  TABLE 15                                                         ______________________________________                                         General Formula 15                                                             Z.sup.1                                                                             R.sup.1     R.sup.2                                                                               R    X      Y       Z.sup.4                            ______________________________________                                         CH   H           H      H    OCH.sub.3                                                                             OCH.sub.3                                                                              CH                                 CH   H           H      H    OCH.sub.3                                                                             CH.sub.3                                                                               CH                                 CH   H           H      H    Cl     OCH.sub.3                                                                              CH                                 CH   H           H      H    CH.sub.3                                                                              CH.sub.3                                                                               CH                                 CH   H           H      H    OCH.sub.3                                                                             OCH.sub.3                                                                              N                                  CH   H           H      H    OCH.sub.3                                                                             CH.sub.3                                                                               N                                  CH   H           H      H    OC.sub.2 H.sub.5                                                                      NHCH.sub.3                                                                             N                                  CH   H           H      CH.sub.3                                                                            OCH.sub.3                                                                             CH.sub.3                                                                               N                                  CH   Cl          H      H    OCH.sub.3                                                                             OCH.sub.3                                                                              CH                                 CH   Cl          H      H    OCH.sub.3                                                                             CH.sub.3                                                                               CH                                 CH   Cl          H      H    Cl     OCH.sub.3                                                                              CH                                 CH   Cl          H      H    CH.sub.3                                                                              CH.sub.3                                                                               CH                                 CH   Cl          H      H    OCH.sub.3                                                                             OCH.sub.3                                                                              N                                  CH   Cl          H      H    OCH.sub.3                                                                             CH.sub.3                                                                               N                                  CH   Cl          H      H    OC.sub.2 H.sub.5                                                                      NHCH.sub.3                                                                             N                                  CH   Cl          H      CH.sub.3                                                                            OCH.sub.3                                                                             CH.sub.3                                                                               N                                  CH   SO.sub. 2 CH.sub.3                                                                         H      H    OCH.sub.3                                                                             OCH.sub.3                                                                              CH                                 CH   SO.sub.2 CH.sub.3                                                                          H      H    OCH.sub.3                                                                             CH.sub.3                                                                               CH                                 CH   SO.sub.2 CH.sub.3                                                                          H      H    Cl     OCH.sub.3                                                                              CH                                 CH   SO.sub.2 CH.sub.3                                                                          H      H    CH.sub.3                                                                              CH.sub.3                                                                               CH                                 CH   SO.sub.2 CH.sub.3                                                                          H      H    OCH.sub.3                                                                             OCH.sub.3                                                                              N                                  CH   SO.sub.2 CH.sub.3                                                                          H      H    OCH.sub.3                                                                             CH.sub.3                                                                               N                                  CH   SO.sub.2 CH.sub.3                                                                          H      H    OC.sub.2 H.sub.5                                                                      NHCH.sub.3                                                                             N                                  CH   SO.sub.2 CH.sub.3                                                                          H      CH.sub.3                                                                            OCH.sub.3                                                                             CH.sub.3                                                                               N                                  CH   CO.sub.2 CH.sub.3                                                                          H      H    OCH.sub.3                                                                             OCH.sub.3                                                                              CH                                 CH   CO.sub.2 CH.sub.3                                                                          H      H    OCH.sub.3                                                                             CH.sub.3                                                                               CH                                 CH   CO.sub.2 CH.sub.3                                                                          H      H    Cl     OCH.sub.3                                                                              CH                                 CH   CO.sub.2 CH.sub.3                                                                          H      H    CH.sub.3                                                                              CH.sub.3                                                                               CH                                 CH   CO.sub.2 CH.sub.3                                                                          H      H    OCH.sub.3                                                                             OCH.sub.3                                                                              N                                  CH   CO.sub.2 CH.sub.3                                                                          H      H    OCH.sub.3                                                                             CH.sub.3                                                                               N                                  CH   CO.sub.2 CH.sub.3                                                                          H      H    OC.sub.2 H.sub.5                                                                      NHCH.sub.3                                                                             N                                  CH   CO.sub.2 CH.sub.3                                                                          H      CH.sub.3                                                                            OCH.sub.3                                                                             CH.sub.3                                                                               N                                  CH   CO.sub.2 C.sub.2 H.sub.5                                                                   H      H    OCH.sub.3                                                                             OCH.sub.3                                                                              CH                                 CH   CO.sub.2 C.sub.2 H.sub.5                                                                   H      H    OCH.sub.3                                                                             CH.sub.3                                                                               CH                                 CH   CO.sub.2 C.sub.2 H.sub.5                                                                   H      H    Cl     OCH.sub.3                                                                              CH                                 CH   CO.sub.2 C.sub.2 H.sub.5                                                                   H      H    CH.sub.3                                                                              CH.sub.3                                                                               CH                                 CH   CO.sub.2 C.sub.2 H.sub.5                                                                   H      H    OCH.sub.3                                                                             OCH.sub.3                                                                              N                                  CH   CO.sub.2 C.sub.2 H.sub.5                                                                   H      H    OCH.sub.3                                                                             CH.sub.3                                                                               N                                  CH   CO.sub.2 C.sub.2 H.sub.5                                                                   H      H    OC.sub.2 H.sub.5                                                                      NHCH.sub.3                                                                             N                                  CH   CO.sub.2 C.sub.2 H.sub.5                                                                   H      CH.sub.3                                                                            OCH.sub.3                                                                             CH.sub.3                                                                               N                                  CH   SO.sub.2 N(CH.sub.3).sub.2                                                                 H      H    OCH.sub.3                                                                             OCH.sub.3                                                                              CH                                 CH   SO.sub.2 N(CH.sub.3).sub.2                                                                 H      H    OCH.sub.3                                                                             CH.sub.3                                                                               CH                                 CH   SO.sub.2 N(CH.sub.3).sub.2                                                                 H      H    Cl     OCH.sub.3                                                                              CH                                 CH   SO.sub.2 N(CH.sub.3).sub.2                                                                 H      H    CH.sub.3                                                                              CH.sub.3                                                                               CH                                 CH   SO.sub.2 N(CH.sub.3).sub.2                                                                 H      H    OCH.sub.3                                                                             OCH.sub.3                                                                              N                                  CH   SO.sub.2 N(CH.sub.3).sub.2                                                                 H      H    OCH.sub.3                                                                             CH.sub.3                                                                               N                                  CH   SO.sub.2 N(CH.sub.3).sub.2                                                                 H      H    OC.sub.2 H.sub.5                                                                      NHCH.sub.3                                                                             N                                  CH   SO.sub.2 N(CH.sub.3).sub.2                                                                 H      CH.sub.3                                                                            OCH.sub.3                                                                             CH.sub.3                                                                               N                                  N    H           H      H    OCH.sub.3                                                                             OCH.sub.3                                                                              CH                                 N    H           H      H    OCH.sub.3                                                                             CH.sub.3                                                                               CH                                 N    H           H      H    Cl     OCH.sub.3                                                                              CH                                 N    H           H      H    CH.sub.3                                                                              CH.sub.3                                                                               CH                                 N    H           H      H    OCH.sub.3                                                                             OCH.sub.3                                                                              N                                  N    H           H      H    OCH.sub.3                                                                             CH.sub.3                                                                               N                                  N    H           H      H    OC.sub.2 H.sub.5                                                                      NHCH.sub.3                                                                             N                                  N    H           H      CH.sub.3                                                                            OCH.sub.3                                                                             CH.sub.3                                                                               N                                  N    Cl          H      H    OCH.sub.3                                                                             OCH.sub.3                                                                              CH                                 N    Cl          H      H    OCH.sub.3                                                                             CH.sub.3                                                                               CH                                 N    Cl          H      H    Cl     OCH.sub.3                                                                              CH                                 N    Cl          H      H    CH.sub.3                                                                              CH.sub.3                                                                               CH                                 N    Cl          H      H    OCH.sub.3                                                                             OCH.sub.3                                                                              N                                  N    Cl          H      H    OCH.sub.3                                                                             CH.sub.3                                                                               N                                  N    Cl          H      H    OC.sub.2 H.sub.5                                                                      NHCH.sub.3                                                                             N                                  N    Cl          H      CH.sub.3                                                                            OCH.sub.3                                                                             CH.sub.3                                                                               N                                  N    SO.sub.2 CH.sub.3                                                                          H      H    OCH.sub.3                                                                             OCH.sub.3                                                                              CH                                 N    SO.sub.2 CH.sub.3                                                                          H      H    OCH.sub.3                                                                             CH.sub. 3                                                                              CH                                 N    SO.sub.2 CH.sub.3                                                                          H      H    Cl     OCH.sub.3                                                                              CH                                 N    SO.sub.2 CH.sub.3                                                                          H      H    CH.sub.3                                                                              CH.sub.3                                                                               CH                                 N    SO.sub.2 CH.sub.3                                                                          H      H    OCH.sub.3                                                                             OCH.sub.3                                                                              N                                  N    SO.sub.2 CH.sub.3                                                                          H      H    OCH.sub.3                                                                             CH.sub.3                                                                               N                                  N    SO.sub.2 CH.sub.3                                                                          H      H    OC.sub.2 H.sub.5                                                                      NHCH.sub.3                                                                             N                                  N    SO.sub.2 CH.sub.3                                                                          H      CH.sub.3                                                                            OCH.sub.3                                                                             CH.sub.3                                                                               N                                  N    CO.sub.2 CH.sub.3                                                                          H      H    OCH.sub.3                                                                             OCH.sub.3                                                                              CH                                 N    CO.sub.2 CH.sub.3                                                                          H      H    OCH.sub.3                                                                             CH.sub.3                                                                               CH                                 N    CO.sub.2 CH.sub.3                                                                          H      H    Cl     OCH.sub.3                                                                              CH                                 N    CO.sub.2 CH.sub.3                                                                          H      H    CH.sub.3                                                                              CH.sub.3                                                                               CH                                 N    CO.sub.2 CH.sub.3                                                                          H      H    OCH.sub.3                                                                             OCH.sub.3                                                                              N                                  N    CO.sub.2 CH.sub.3                                                                          H      H    OCH.sub.3                                                                             CH.sub.3                                                                               N                                  N    CO.sub.2 CH.sub.3                                                                          H      H    OC.sub.2 H.sub.5                                                                      NHCH.sub.3                                                                             N                                  N    CO.sub.2 CH.sub.3                                                                          H      CH.sub.3                                                                            OCH.sub.3                                                                             CH.sub.3                                                                               N                                  N    CO.sub.2 C.sub.2 H.sub.5                                                                   H      H    OCH.sub.3                                                                             OCH.sub.3                                                                              CH                                 N    CO.sub.2 C.sub.2 H.sub.5                                                                   H      H    OCH.sub.3                                                                             CH.sub. 3                                                                              CH                                 N    CO.sub.2 C.sub.2 H.sub.5                                                                   H      H    Cl     OCH.sub.3                                                                              CH                                 N    CO.sub.2 C.sub.2 H.sub.5                                                                   H      H    CH.sub.3                                                                              CH.sub.3                                                                               CH                                 N    CO.sub.2 C.sub.2 H.sub.5                                                                   H      H    OCH.sub.3                                                                             OCH.sub.3                                                                              N                                  N    CO.sub.2 C.sub.2 H.sub.5                                                                   H      H    OCH.sub.3                                                                             CH.sub.3                                                                               N                                  N    CO.sub.2 C.sub.2 H.sub.5                                                                   H      H    OC.sub.2 H.sub.5                                                                      NHCH.sub.3                                                                             N                                  N    CO.sub.2 C.sub.2 H.sub.5                                                                   H      CH.sub.3                                                                            OCH.sub.3                                                                             CH.sub.3                                                                               N                                  N    SO.sub.2 N(CH.sub.3).sub.2                                                                 H      H    OCH.sub.3                                                                             OCH.sub.3                                                                              CH                                 N    SO.sub.2 N(CH.sub.3).sub.2                                                                 H      H    OCH.sub.3                                                                             CH.sub.3                                                                               CH                                 N    SO.sub.2 N(CH.sub.3).sub.2                                                                 H      H    Cl     OCH.sub.3                                                                              CH                                 N    SO.sub.2 N(CH.sub.3).sub.2                                                                 H      H    CH.sub.3                                                                              CH.sub.3                                                                               CH                                 N    SO.sub.2 N(CH.sub.3).sub.2                                                                 H      H    OCH.sub.3                                                                             OCH.sub.3                                                                              N                                  N    SO.sub.2 N(CH.sub.3).sub.2                                                                 H      H    OCH.sub.3                                                                             CH.sub.3                                                                               N                                  N    SO.sub.2 N(CH.sub.3).sub.2                                                                 H      H    OC.sub.2 H.sub.5                                                                      NHCH.sub.3                                                                             N                                  N    SO.sub.2 N(CH.sub.3).sub.2                                                                 H      CH.sub.3                                                                            OCH.sub.3                                                                             CH.sub. 3                                                                              N                                  ______________________________________                                    

                  TABLE 16                                                         ______________________________________                                         General Formula 16                                                             Z.sup.1                                                                              R.sup.2  R.sup.4                                                                               R     X      Y       Z.sup.4                             ______________________________________                                         CH    H        H      H     OCH.sub.3                                                                             OCH.sub.3                                                                              CH                                  CH    H        H      H     OCH.sub.3                                                                             CH.sub.3                                                                               CH                                  CH    H        H      H     Cl     OCH.sub.3                                                                              CH                                  CH    H        H      H     CH.sub.3                                                                              CH.sub.3                                                                               CH                                  CH    H        H      H     OCH.sub.3                                                                             OCH.sub.3                                                                              N                                   CH    H        H      H     OCH.sub.3                                                                             CH.sub.3                                                                               N                                   CH    H        H      H     OC.sub.2 H.sub.5                                                                      NHCH.sub.3                                                                             N                                   CH    H        H      CH.sub.3                                                                             OCH.sub.3                                                                             CH.sub.3                                                                               N                                   CH    CH.sub.3 H      H     OCH.sub.3                                                                             OCH.sub.3                                                                              CH                                  CH    CH.sub.3 H      H     OCH.sub.3                                                                             CH.sub.3                                                                               CH                                  CH    CH.sub.3 H      H     Cl     OCH.sub.3                                                                              CH                                  CH    CH.sub.3 H      H     CH.sub.3                                                                              CH.sub.3                                                                               CH                                  CH    CH.sub.3 H      H     OCH.sub.3                                                                             OCH.sub.3                                                                              N                                   CH    CH.sub.3 H      H     OCH.sub.3                                                                             CH.sub.3                                                                               N                                   CH    CH.sub.3 H      H     OC.sub.2 H.sub.5                                                                      NHCH.sub.3                                                                             N                                   CH    CH.sub.3 H      CH.sub.3                                                                             OCH.sub.3                                                                             CH.sub.3                                                                               N                                   CH    OCH.sub.3                                                                               H      H     OCH.sub.3                                                                             OCH.sub.3                                                                              CH                                  CH    OCH.sub.3                                                                               H      H     OCH.sub.3                                                                             CH.sub.3                                                                               CH                                  CH    OCH.sub.3                                                                               H      H     Cl     OCH.sub.3                                                                              CH                                  CH    OCH.sub.3                                                                               H      H     CH.sub.3                                                                              CH.sub.3                                                                               CH                                  CH    OCH.sub.3                                                                               H      H     OCH.sub.3                                                                             OCH.sub.3                                                                              N                                   CH    OCH      H      H     OCH.sub.3                                                                             CH.sub.3                                                                               N                                   CH    OCH.sub.3                                                                               H      H     OC.sub.2 H.sub.5                                                                      NHCH.sub.3                                                                             N                                   CH    OCH.sub.3                                                                               H      CH.sub.3                                                                             OCH.sub.3                                                                             CH.sub.3                                                                               N                                   N     H        H      H     OCH.sub.3                                                                             OCH.sub.3                                                                              CH                                  N     H        H      H     OCH.sub.3                                                                             CH.sub.3                                                                               CH                                  N     H        H      H     Cl     OCH.sub.3                                                                              CH                                  N     H        H      H     CH.sub.3                                                                              CH.sub.3                                                                               CH                                  N     H        H      H     OCH.sub.3                                                                             OCH.sub.3                                                                              N                                   N     H        H      H     OCH.sub.3                                                                             CH.sub.3                                                                               N                                   N     H        H      H     OC.sub.2 H.sub.5                                                                      NHCH.sub.3                                                                             N                                   N     H        H      CH.sub.3                                                                             OCH.sub.3                                                                             CH.sub.3                                                                               N                                   N     CH.sub.3 H      H     OCH.sub.3                                                                             OCH.sub.3                                                                              CH                                  N     CH.sub.3 H      H     OCH.sub.3                                                                             CH.sub.3                                                                               CH                                  N     CH.sub.3 H      H     Cl     OCH.sub.3                                                                              CH                                  N     CH.sub.3 H      H     CH.sub.3                                                                              CH.sub.3                                                                               CH                                  N     CH.sub.3 H      H     OCH.sub.3                                                                             OCH.sub.3                                                                              N                                   N     CH.sub.3 H      H     OCH.sub. 3                                                                            CH.sub.3                                                                               N                                   N     CH.sub.3 H      H     OC.sub.2 H.sub.5                                                                      NHCH.sub.3                                                                             N                                   N     CH.sub.3 H      CH.sub.3                                                                             OCH.sub.3                                                                             CH.sub.3                                                                               N                                   N     OCH.sub.3                                                                               H      H     OCH.sub.3                                                                             OCH.sub.3                                                                              CH                                  N     OCH.sub.3                                                                               H      H     OCH.sub.3                                                                             CH.sub.3                                                                               CH                                  N     OCH.sub.3                                                                               H      H     Cl     OCH.sub.3                                                                              CH                                  N     OCH.sub.3                                                                               H      H     CH.sub.3                                                                              CH.sub.3                                                                               CH                                  N     OCH.sub.3                                                                               H      H     OCH.sub.3                                                                             OCH.sub.3                                                                              N                                   N     OCH.sub.3                                                                               H      H     OCH.sub.3                                                                             CH.sub.3                                                                               N                                   N     OCH.sub.3                                                                               H      H     OC.sub.2 H.sub.5                                                                      NHCH.sub.3                                                                             N                                   N     OCH.sub.3                                                                               H      CH.sub.3                                                                             OCH.sub.3                                                                             CH.sub.3                                                                               N                                   ______________________________________                                    

                  TABLE 17                                                         ______________________________________                                         General Formula 17                                                             Z     Z.sup.2 R.sup.2                                                                               R.sup.3                                                                             R    X      Y      Z.sup.4                           ______________________________________                                         CH    O       CH.sub.3                                                                              CH.sub.3                                                                            H    OCH.sub.3                                                                             OCH.sub.3                                                                             CH                                CH    O       CH.sub.3                                                                              CH.sub.3                                                                            H    OCH.sub.3                                                                             CH.sub.3                                                                              CH                                CH    O       CH.sub.3                                                                              CH.sub.3                                                                            H    Cl     OCH.sub.3                                                                             CH                                CH    O       CH.sub.3                                                                              CH.sub.3                                                                            H    CH.sub.3                                                                              CH.sub.3                                                                              CH                                CH    O       CH.sub.3                                                                              CH.sub.3                                                                            H    OCH.sub.3                                                                             OCH.sub.3                                                                             N                                 CH    O       CH.sub.3                                                                              CH.sub.3                                                                            H    OCH.sub.3                                                                             CH.sub.3                                                                              N                                 CH    O       CH.sub.3                                                                              CH.sub.3                                                                            H    OC.sub.2 H.sub.5                                                                      NHCH.sub.3                                                                            N                                 CH    O       CH.sub.3                                                                              CH.sub.3                                                                            CH.sub.3                                                                            OCH.sub.3                                                                             CH.sub.3                                                                              N                                 N     O       CH.sub.3                                                                              CH.sub.3                                                                            H    OCH.sub.3                                                                             OCH.sub.3                                                                             CH                                N     O       CH.sub.3                                                                              CH.sub.3                                                                            H    OCH.sub.3                                                                             CH.sub.3                                                                              CH                                N     O       CH.sub.3                                                                              CH.sub.3                                                                            H    Cl     OCH.sub.3                                                                             CH                                N     O       CH.sub.3                                                                              CH.sub.3                                                                            H    CH.sub.3                                                                              CH.sub.3                                                                              CH                                N     O       CH.sub.3                                                                              CH.sub.3                                                                            H    OCH.sub.3                                                                             OCH.sub.3                                                                             N                                 N     O       CH.sub.3                                                                              CH.sub.3                                                                            H    OCH.sub.3                                                                             CH.sub.3                                                                              N                                 N     O       CH.sub.3                                                                              CH.sub.3                                                                            H    OC.sub.2 H.sub.5                                                                      NHCH.sub.3                                                                            N                                 N     O       CH.sub.3                                                                              CH.sub.3                                                                            CH.sub.3                                                                            OCH.sub.3                                                                             CH.sub.3                                                                              N                                 CH    S       CH.sub.3                                                                              CH.sub.3                                                                            H    OCH.sub.3                                                                             OCH.sub.3                                                                             CH                                CH    S       CH.sub.3                                                                              CH.sub.3                                                                            H    OCH.sub.3                                                                             CH.sub.3                                                                              CH                                CH    S       CH.sub.3                                                                              CH.sub.3                                                                            H    Cl     OCH.sub.3                                                                             CH                                CH    S       CH.sub.3                                                                              CH.sub.3                                                                            H    CH.sub.3                                                                              CH.sub.3                                                                              CH                                CH    S       CH.sub.3                                                                              CH.sub.3                                                                            H    OCH.sub.3                                                                             OCH.sub.3                                                                             N                                 CH    S       CH.sub.3                                                                              CH.sub.3                                                                            H    OCH.sub.3                                                                             CH.sub.3                                                                              N                                 CH    S       CH.sub.3                                                                              CH.sub.3                                                                            H    OC.sub.2 H.sub.5                                                                      NHCH.sub.3                                                                            N                                 CH    S       CH.sub.3                                                                              CH.sub.3                                                                            CH.sub.3                                                                            OCH.sub.3                                                                             CH.sub.3                                                                              N                                 CH    O       CH.sub.3                                                                              H    H    OCH.sub.3                                                                             OCH.sub.3                                                                             CH                                CH    O       CH.sub.3                                                                              H    H    OCH.sub.3                                                                             CH.sub.3                                                                              CH                                CH    O       CH.sub.3                                                                              H    H    Cl     OCH.sub.3                                                                             CH                                CH    O       CH.sub.3                                                                              H    H    CH.sub.3                                                                              CH.sub.3                                                                              CH                                CH    O       CH.sub.3                                                                              H    H    OCH.sub.3                                                                             OCH.sub.3                                                                             N                                 CH    O       CH.sub.3                                                                              H    H    OCH.sub.3                                                                             CH.sub.3                                                                              N                                 CH    O       CH.sub.3                                                                              H    H    OC.sub.2 H.sub.5                                                                      NHCH.sub.3                                                                            N                                 CH    O       CH.sub.3                                                                              H    CH.sub.3                                                                            OCH.sub.3                                                                             CH.sub.3                                                                              N                                 N     O       CH.sub.3                                                                              H    H    OCH.sub.3                                                                             OCH.sub.3                                                                             CH                                N     O       CH.sub.3                                                                              H    H    OCH.sub.3                                                                             CH.sub.3                                                                              CH                                N     O       CH.sub.3                                                                              H    H    Cl     OCH.sub.3                                                                             CH                                N     O       CH.sub.3                                                                              H    H    CH.sub.3                                                                              CH.sub.3                                                                              CH                                N     O       CH.sub.3                                                                              H    H    OCH.sub.3                                                                             OCH.sub.3                                                                             N                                 N     O       CH.sub.3                                                                              H    H    OCH.sub.3                                                                             CH.sub.3                                                                              N                                 N     O       CH.sub.3                                                                              H    H    OC.sub.2 H.sub.5                                                                      NHCH.sub.3                                                                            N                                 N     O       CH.sub.3                                                                              H    CH.sub.3                                                                            OCH.sub.3                                                                             CH.sub.3                                                                              N                                 CH    S       CH.sub.3                                                                              H    H    OCH.sub.3                                                                             OCH.sub.3                                                                             CH                                CH    S       CH.sub.3                                                                              H    H    OCH.sub.3                                                                             CH.sub.3                                                                              CH                                CH    S       CH.sub.3                                                                              H    H    Cl     OCH.sub.3                                                                             CH                                CH    S       CH.sub.3                                                                              H    H    CH.sub.3                                                                              CH.sub.3                                                                              CH                                CH    S       CH.sub.3                                                                              H    H    OCH.sub.3                                                                             OCH.sub.3                                                                             N                                 CH    S       CH.sub.3                                                                              H    H    OCH.sub.3                                                                             CH.sub.3                                                                              N                                 CH    S       CH.sub.3                                                                              H    H    OC.sub.2 H.sub.5                                                                      NHCH.sub.3                                                                            N                                 CH    S       CH.sub.3                                                                              H    CH.sub.3                                                                            OCH.sub.3                                                                             CH.sub.3                                                                              N                                 CH    O       H      CH.sub.3                                                                            H    OCH.sub.3                                                                             OCH.sub.3                                                                             CH                                CH    O       H      CH.sub.3                                                                            H    OCH.sub.3                                                                             CH.sub.3                                                                              CH                                CH    O       H      CH.sub.3                                                                            H    Cl     OCH.sub.3                                                                             CH                                CH    O       H      CH.sub.3                                                                            H    CH.sub.3                                                                              CH.sub.3                                                                              CH                                CH    O       H      CH.sub.3                                                                            H    OCH.sub.3                                                                             OCH.sub.3                                                                             N                                 CH    O       H      CH.sub.3                                                                            H    OCH.sub.3                                                                             CH.sub.3                                                                              N                                 CH    O       H      CH.sub.3                                                                            H    OC.sub.2 H.sub.5                                                                      NHCH.sub.3                                                                            N                                 CH    O       H      CH.sub.3                                                                            CH.sub.3                                                                            OCH.sub.3                                                                             CH.sub.3                                                                              N                                 N     O       H      CH.sub.3                                                                            H    OCH.sub.3                                                                             OCH.sub.3                                                                             CH                                N     O       H      CH.sub.3                                                                            H    OCH.sub.3                                                                             CH.sub.3                                                                              CH                                N     O       H      CH.sub.3                                                                            H    Cl     OCH.sub.3                                                                             CH                                N     O       H      CH.sub.3                                                                            H    CH.sub.3                                                                              CH.sub.3                                                                              CH                                N     O       H      CH.sub.3                                                                            H    OCH.sub.3                                                                             OCH.sub.3                                                                             N                                 N     O       H      CH.sub.3                                                                            H    OCH.sub.3                                                                             CH.sub.3                                                                              N                                 N     O       H      CH.sub.3                                                                            H    OC.sub.2 H.sub.5                                                                      NHCH.sub.3                                                                            N                                 N     O       H      CH.sub.3                                                                            CH.sub.3                                                                            OCH.sub.3                                                                             CH.sub.3                                                                              N                                 CH    S       H      CH.sub.3                                                                            H    OCH.sub.3                                                                             OCH.sub.3                                                                             CH                                CH    S       H      CH.sub.3                                                                            H    OCH.sub.3                                                                             CH.sub.3                                                                              CH                                CH    S       H      CH.sub.3                                                                            H    Cl     OCH.sub.3                                                                             CH                                CH    S       H      CH.sub.3                                                                            H    CH.sub.3                                                                              CH.sub.3                                                                              CH                                CH    S       H      CH.sub.3                                                                            H    OCH.sub.3                                                                             OCH.sub.3                                                                             N                                 CH    S       H      CH.sub.3                                                                            H    OCH.sub.3                                                                             CH.sub.3                                                                              N                                 CH    S       H      CH.sub.3                                                                            H    OC.sub.2 H.sub.5                                                                      NHCH.sub.3                                                                            N                                 CH    S       H      CH.sub.3                                                                            CH.sub.3                                                                            OCH.sub.3                                                                             CH.sub.3                                                                              N                                 CH    O       H      H    H    OCH.sub.3                                                                             OCH.sub.3                                                                             CH                                CH    O       H      H    H    OCH.sub.3                                                                             CH.sub.3                                                                              CH                                CH    O       H      H    H    Cl     OCH.sub.3                                                                             CH                                CH    O       H      H    H    CH.sub.3                                                                              CH.sub.3                                                                              CH                                CH    O       H      H    H    OCH.sub.3                                                                             OCH.sub.3                                                                             N                                 CH    O       H      H    H    OCH.sub.3                                                                             CH.sub.3                                                                              N                                 CH    O       H      H    H    OC.sub.2 H.sub.5                                                                      NHCH.sub.3                                                                            N                                 CH    O       H      H    CH.sub.3                                                                            OCH.sub.3                                                                             CH.sub.3                                                                              N                                 N     O       H      H    H    OCH.sub.3                                                                             OCH.sub.3                                                                             CH                                N     O       H      H    H    OCH.sub.3                                                                             CH.sub.3                                                                              CH                                N     O       H      H    H    Cl     OCH.sub.3                                                                             CH                                N     O       H      H    H    CH.sub.3                                                                              CH.sub.3                                                                              CH                                N     O       H      H    H    OCH.sub.3                                                                             OCH.sub. 3                                                                            N                                 N     O       H      H    H    OCH.sub.3                                                                             CH.sub.3                                                                              N                                 N     O       H      H    H    OC.sub.2 H.sub.5                                                                      NHCH.sub.3                                                                            N                                 N     O       H      H    CH.sub.3                                                                            OCH.sub.3                                                                             CH.sub.3                                                                              N                                 CH    S       H      H    H    OCH.sub.3                                                                             OCH.sub.3                                                                             CH                                CH    S       H      H    H    OCH.sub.3                                                                             CH.sub.3                                                                              CH                                CH    S       H      H    H    Cl     OCH.sub.3                                                                             CH                                CH    S       H      H    H    CH     CH.sub.3                                                                              CH                                CH    S       H      H    H    OCH.sub.3                                                                             OCH.sub.3                                                                             N                                 CH    S       H      H    H    OCH.sub.3                                                                             CH.sub.3                                                                              N                                 CH    S       H      H    H    OC.sub.2 H.sub.5                                                                      NHCH.sub.3                                                                            N                                 CH    S       H      H    CH.sub.3                                                                            OCH.sub.3                                                                             CH.sub.3                                                                              N                                 N     S       CH.sub.3                                                                              CH.sub.3                                                                            H    OCH.sub.3                                                                             OCH.sub.3                                                                             CH                                N     S       CH.sub.3                                                                              CH.sub.3                                                                            H    OCH.sub.3                                                                             CH.sub.3                                                                              CH                                N     S       CH.sub.3                                                                              CH.sub.3                                                                            H    Cl     OCH.sub.3                                                                             CH                                N     S       CH.sub.3                                                                              CH.sub.3                                                                            H    CH.sub.3                                                                              CH.sub.3                                                                              CH                                N     S       CH.sub.3                                                                              CH.sub.3                                                                            H    OCH.sub.3                                                                             OCH.sub.3                                                                             N                                 N     S       CH.sub.3                                                                              CH.sub.3                                                                            H    OCH.sub.3                                                                             CH.sub.3                                                                              N                                 N     S       CH.sub.3                                                                              CH.sub.3                                                                            H    OC.sub.2 H.sub.5                                                                      NHCH.sub.3                                                                            N                                 N     S       CH.sub.3                                                                              CH.sub.3                                                                            CH.sub.3                                                                            OCH.sub.3                                                                             CH.sub.3                                                                              N                                 CH    NCH.sub.3                                                                              CH.sub.3                                                                              CH.sub.3                                                                            H    OCH.sub.3                                                                             OCH.sub.3                                                                             CH                                CH    NCH.sub.3                                                                              CH.sub.3                                                                              CH.sub.3                                                                            H    OCH.sub.3                                                                             CH.sub.3                                                                              CH                                CH    NCH.sub.3                                                                              CH.sub.3                                                                              CH.sub.3                                                                            H    Cl     OCH.sub.3                                                                             CH                                CH    NCH.sub.3                                                                              CH.sub.3                                                                              CH.sub.3                                                                            H    CH.sub.3                                                                              CH.sub.3                                                                              CH                                CH    NCH.sub.3                                                                              CH.sub.3                                                                              CH.sub.3                                                                            H    OCH.sub.3                                                                             OCH.sub.3                                                                             N                                 CH    NCH.sub.3                                                                              CH.sub.3                                                                              CH.sub.3                                                                            H    OCH.sub.3                                                                             CH.sub.3                                                                              N                                 CH    NCH.sub.3                                                                              CH.sub.3                                                                              CH.sub.3                                                                            H    OC.sub.2 H.sub.5                                                                      NHCH.sub.3                                                                            N                                 CH    NCH.sub.3                                                                              CH.sub.3                                                                              CH.sub.3                                                                            CH.sub.3                                                                            OCH.sub.3                                                                             CH.sub.3                                                                              N                                 N     NCH.sub.3                                                                              CH.sub.3                                                                              CH.sub.3                                                                            H    OCH.sub.3                                                                             OCH.sub.3                                                                             CH                                N     NCH.sub.3                                                                              CH.sub.3                                                                              CH.sub.3                                                                            H    OCH.sub.3                                                                             CH.sub.3                                                                              CH                                N     NCH.sub.3                                                                              CH.sub.3                                                                              CH.sub.3                                                                            H    Cl     OCH.sub.3                                                                             CH                                N     NCH.sub.3                                                                              CH.sub.3                                                                              CH.sub.3                                                                            H    CH.sub.3                                                                              CH.sub.3                                                                              CH                                N     NCH.sub.3                                                                              CH.sub.3                                                                              CH.sub.3                                                                            H    OCH.sub.3                                                                             OCH.sub.3                                                                             N                                 N     NCH.sub.3                                                                              CH.sub.3                                                                              CH.sub.3                                                                            H    OCH.sub.3                                                                             CH.sub.3                                                                              N                                 N     NCH.sub.3                                                                              CH.sub.3                                                                              CH.sub.3                                                                            H    OC.sub.2 H.sub.5                                                                      NHCH.sub.3                                                                            N                                 N     NCH.sub.3                                                                              CH.sub.3                                                                              CH.sub.3                                                                            CH.sub.3                                                                            OCH.sub.3                                                                             CH.sub.3                                                                              N                                 N     S       CH.sub.3                                                                              H    H    OCH.sub.3                                                                             OCH.sub.3                                                                             CH                                N     S       CH.sub.3                                                                              H    H    OCH.sub.3                                                                             CH.sub.3                                                                              CH                                N     S       CH.sub.3                                                                              H    H    Cl     OCH.sub.3                                                                             CH                                N     S       CH.sub.3                                                                              H    H    CH.sub.3                                                                              CH.sub.3                                                                              CH                                N     S       CH.sub.3                                                                              H    H    OCH.sub.3                                                                             OCH.sub.3                                                                             N                                 N     S       CH.sub.3                                                                              H    H    OCH.sub.3                                                                             CH.sub.3                                                                              N                                 N     S       CH.sub.3                                                                              H    H    OC.sub.2 H.sub.5                                                                      NHCH.sub.3                                                                            N                                 N     S       CH.sub.3                                                                              H    CH.sub.3                                                                            OCH.sub.3                                                                             CH.sub.3                                                                              N                                 CH    NCH.sub.3                                                                              CH.sub.3                                                                              H    H    OCH.sub.3                                                                             OCH.sub.3                                                                             CH                                CH    NCH.sub.3                                                                              CH.sub.3                                                                              H    H    OCH.sub.3                                                                             CH.sub.3                                                                              CH                                CH    NCH.sub.3                                                                              CH.sub.3                                                                              H    H    Cl     OCH.sub.3                                                                             CH                                CH    NCH.sub.3                                                                              CH.sub.3                                                                              H    H    CH.sub.3                                                                              CH.sub.3                                                                              CH                                CH    NCH.sub.3                                                                              CH.sub.3                                                                              H    H    OCH.sub.3                                                                             OCH.sub.3                                                                             N                                 CH    NCH.sub.3                                                                              CH.sub.3                                                                              H    H    OCH.sub.3                                                                             CH.sub.3                                                                              N                                 CH    NCH.sub.3                                                                              CH.sub.3                                                                              H    H    OC.sub.2 H.sub.5                                                                      NHCH.sub.3                                                                            N                                 CH    NCH.sub.3                                                                              CH.sub.3                                                                              H    CH.sub.3                                                                            OCH.sub.3                                                                             CH.sub.3                                                                              N                                 N     NCH.sub.3                                                                              CH.sub.3                                                                              H    H    OCH.sub.3                                                                             OCH.sub.3                                                                             CH                                N     NCH.sub.3                                                                              CH.sub.3                                                                              H    H    OCH.sub.3                                                                             CH.sub.3                                                                              CH                                N     NCH.sub.3                                                                              CH.sub.3                                                                              H    H    Cl     OCH.sub.3                                                                             CH                                N     NCH.sub.3                                                                              CH.sub.3                                                                              H    H    CH.sub.3                                                                              CH.sub.3                                                                              CH                                N     NCH.sub.3                                                                              CH.sub.3                                                                              H    H    OCH.sub.3                                                                             OCH.sub.3                                                                             N                                 N     NCH.sub.3                                                                              CH.sub.3                                                                              H    H    OCH.sub.3                                                                             CH.sub.3                                                                              N                                 N     NCH.sub.3                                                                              CH.sub.3                                                                              H    H    OC.sub.2 H.sub.5                                                                      NHCH.sub.3                                                                            N                                 N     NCH.sub.3                                                                              CH.sub.3                                                                              H    CH.sub.3                                                                            OCH.sub.3                                                                             CH.sub.3                                                                              N                                 N     S       H      CH.sub.3                                                                            H    OCH.sub.3                                                                             OCH.sub.3                                                                             CH                                N     S       H      CH.sub.3                                                                            H    OCH.sub.3                                                                             CH.sub.3                                                                              CH                                N     S       H      CH.sub.3                                                                            H    Cl     OCH.sub.3                                                                             CH                                N     S       H      CH.sub.3                                                                            H    CH.sub.3                                                                              CH.sub.3                                                                              CH                                N     S       H      CH.sub.3                                                                            H    OCH.sub.3                                                                             OCH.sub.3                                                                             N                                 N     S       H      CH.sub.3                                                                            H    OCH.sub.3                                                                             CH.sub.3                                                                              N                                 N     S       H      CH.sub.3                                                                            H    OC.sub.2 H.sub.5                                                                      NHCH.sub.3                                                                            N                                 N     S       H      CH.sub.3                                                                            CH.sub.3                                                                            OCH.sub.3                                                                             CH.sub.3                                                                              N                                 CH    NCH.sub.3                                                                              H      CH.sub.3                                                                            H    OCH.sub.3                                                                             OCH.sub.3                                                                             CH                                CH    NCH.sub.3                                                                              H      CH.sub.3                                                                            H    OCH.sub.3                                                                             CH.sub.3                                                                              CH                                CH    NCH.sub.3                                                                              H      CH.sub.3                                                                            H    Cl     OCH.sub.3                                                                             CH                                CH    NCH.sub.3                                                                              H      CH.sub.3                                                                            H    CH.sub.3                                                                              CH.sub.3                                                                              CH                                CH    NCH.sub.3                                                                              H      CH.sub.3                                                                            H    OCH.sub.3                                                                             OCH.sub.3                                                                             N                                 CH    NCH.sub.3                                                                              H      CH.sub.3                                                                            H    OCH.sub.3                                                                             CH.sub.3                                                                              N                                 CH    NCH.sub.3                                                                              H      CH.sub.3                                                                            H    OC.sub.2 H.sub.5                                                                      NHCH.sub.3                                                                            N                                 CH    NCH.sub.3                                                                              H      CH.sub.3                                                                            CH.sub.3                                                                            OCH.sub.3                                                                             CH.sub.3                                                                              N                                 N     NCH.sub.3                                                                              H      CH.sub.3                                                                            H    OCH.sub.3                                                                             OCH.sub.3                                                                             CH                                N     NCH.sub.3                                                                              H      CH.sub.3                                                                            H    OCH.sub.3                                                                             CH.sub.3                                                                              CH                                N     NCH.sub.3                                                                              H      CH.sub.3                                                                            H    Cl     OCH.sub.3                                                                             CH                                N     NCH.sub.3                                                                              H      CH.sub.3                                                                            H    CH.sub.3                                                                              CH.sub.3                                                                              CH                                N     NCH.sub.3                                                                              H      CH.sub.3                                                                            H    OCH.sub.3                                                                             OCH.sub.3                                                                             N                                 N     NCH.sub.3                                                                              H      CH.sub.3                                                                            H    OCH.sub.3                                                                             CH.sub.3                                                                              N                                 N     NCH.sub.3                                                                              H      CH.sub.3                                                                            H    OC.sub.2 H.sub.5                                                                      NHCH.sub.3                                                                            N                                 N     NCH.sub.3                                                                              H      CH.sub.3                                                                            CH.sub.3                                                                            OCH.sub.3                                                                             CH.sub.3                                                                              N                                 N     S       H      H    H    OCH.sub.3                                                                             OCH.sub.3                                                                             CH                                N     S       H      H    H    OCH.sub.3                                                                             CH.sub.3                                                                              CH                                N     S       H      H    H    Cl     OCH.sub.3                                                                             CH                                N     S       H      H    H    CH.sub.3                                                                              CH.sub.3                                                                              CH                                N     S       H      H    H    OCH.sub.3                                                                             OCH.sub.3                                                                             N                                 N     S       H      H    H    OCH.sub.3                                                                             CH.sub.3                                                                              N                                 N     S       H      H    H    OC.sub.2 H.sub.5                                                                      NHCH.sub.3                                                                            N                                 N     S       H      H    CH.sub.3                                                                            OCH.sub.3                                                                             CH.sub.3                                                                              N                                 CH    NCH.sub.3                                                                              H      H    H    OCH.sub.3                                                                             OCH.sub.3                                                                             CH                                CH    NCH.sub.3                                                                              H      H    H    OCH.sub.3                                                                             CH.sub.3                                                                              CH                                CH    NCH.sub.3                                                                              H      H    H    Cl     OCH.sub.3                                                                             CH                                CH    NCH.sub.3                                                                              H      H    H    CH.sub.3                                                                              CH.sub.3                                                                              CH                                CH    NCH.sub.3                                                                              H      H    H    OCH.sub.3                                                                             OCH.sub.3                                                                             N                                 CH    NCH.sub.3                                                                              H      H    H    OCH.sub.3                                                                             CH.sub.3                                                                              N                                 CH    NCH.sub.3                                                                              H      H    H    OC.sub.2 H.sub.5                                                                      NHCH.sub.3                                                                            N                                 CH    NCH.sub.3                                                                              H      H    CH.sub.3                                                                            OCH.sub.3                                                                             CH.sub.3                                                                              N                                 N     NCH.sub.3                                                                              H      H    H    OCH.sub.3                                                                             OCH.sub.3                                                                             CH                                N     NCH.sub.3                                                                              H      H    H    OCH.sub.3                                                                             CH.sub.3                                                                              CH                                N     NCH.sub.3                                                                              H      H    H    Cl     OCH.sub.3                                                                             CH                                N     NCH.sub.3                                                                              H      H    H    CH.sub.3                                                                              CH.sub.3                                                                              CH                                N     NCH.sub.3                                                                              H      H    H    OCH.sub.3                                                                             OCH.sub.3                                                                             N                                 N     NCH.sub.3                                                                              H      H    H    OCH.sub.3                                                                             CH.sub.3                                                                              N                                 N     NCH.sub.3                                                                              H      H    H    OC.sub.2 H.sub.5                                                                      NHCH.sub.3                                                                            N                                 N     NCH.sub.3                                                                              H      H    CH.sub.3                                                                            OCH.sub.3                                                                             CH.sub.3                                                                              N                                 ______________________________________                                    

                  TABLE 18                                                         ______________________________________                                         General Formula 18                                                             Z     Z.sup.3 R.sup.2                                                                               R.sup.3                                                                             R    X      Y      Z.sup.4                           ______________________________________                                         CH    O       CH.sub.3                                                                              CH.sub.3                                                                            H    OCH.sub.3                                                                             OCH.sub.3                                                                             CH                                CH    O       CH.sub.3                                                                              CH.sub.3                                                                            H    OCH.sub.3                                                                             CH.sub.3                                                                              CH                                CH    O       CH.sub.3                                                                              CH.sub.3                                                                            H    Cl     OCH.sub.3                                                                             CH                                CH    O       CH.sub.3                                                                              CH.sub.3                                                                            H    CH.sub.3                                                                              CH.sub.3                                                                              CH                                CH    O       CH.sub.3                                                                              CH.sub.3                                                                            H    OCH.sub.3                                                                             OCH.sub.3                                                                             N                                 CH    O       CH.sub.3                                                                              CH.sub.3                                                                            H    OCH.sub.3                                                                             CH.sub.3                                                                              N                                 CH    O       CH.sub.3                                                                              CH.sub.3                                                                            H    OC.sub.2 H.sub.5                                                                      NHCH.sub.3                                                                            N                                 CH    O       CH.sub.3                                                                              CH.sub.3                                                                            CH.sub.3                                                                            OCH.sub.3                                                                             CH.sub.3                                                                              N                                 N     O       CH.sub.3                                                                              CH.sub.3                                                                            H    OCH.sub.3                                                                             OCH.sub.3                                                                             CH                                N     O       CH.sub.3                                                                              CH.sub.3                                                                            H    OCH.sub.3                                                                             CH.sub.3                                                                              CH                                N     O       CH.sub.3                                                                              CH.sub.3                                                                            H    Cl     OCH.sub.3                                                                             CH                                N     O       CH.sub.3                                                                              CH.sub.3                                                                            H    CH.sub.3                                                                              CH.sub.3                                                                              CH                                N     O       CH.sub.3                                                                              CH.sub.3                                                                            H    OCH.sub.3                                                                             OCH.sub.3                                                                             N                                 N     O       CH.sub.3                                                                              CH.sub.3                                                                            H    OCH.sub.3                                                                             CH.sub.3                                                                              N                                 N     O       CH.sub.3                                                                              CH.sub.3                                                                            H    OC.sub.2 H.sub.5                                                                      NHCH.sub.3                                                                            N                                 N     O       CH.sub.3                                                                              CH.sub.3                                                                            CH.sub.3                                                                            OCH.sub.3                                                                             CH.sub.3                                                                              N                                 CH    S       CH.sub.3                                                                              CH.sub.3                                                                            H    OCH.sub.3                                                                             OCH.sub.3                                                                             CH                                CH    S       CH.sub.3                                                                              CH.sub.3                                                                            H    OCH.sub.3                                                                             CH.sub.3                                                                              CH                                CH    S       CH.sub.3                                                                              CH.sub.3                                                                            H    Cl     OCH.sub.3                                                                             CH                                CH    S       CH.sub.3                                                                              CH.sub.3                                                                            H    CH.sub.3                                                                              CH.sub.3                                                                              CH                                CH    S       CH.sub.3                                                                              CH.sub.3                                                                            H    OCH.sub.3                                                                             OCH.sub.3                                                                             N                                 CH    S       CH.sub.3                                                                              CH.sub.3                                                                            H    OCH.sub.3                                                                             CH.sub.3                                                                              N                                 CH    S       CH.sub.3                                                                              CH.sub.3                                                                            H    OC.sub.2 H.sub.5                                                                      NHCH.sub.3                                                                            N                                 CH    S       CH.sub.3                                                                              CH.sub.3                                                                            CH.sub.3                                                                            OCH.sub.3                                                                             CH.sub.3                                                                              N                                 CH    O       CH.sub.3                                                                              H    H    OCH.sub.3                                                                             OCH.sub.3                                                                             CH                                CH    O       CH.sub.3                                                                              H    H    OCH.sub.3                                                                             CH.sub.3                                                                              CH                                CH    O       CH.sub.3                                                                              H    H    Cl     OCH.sub.3                                                                             CH                                CH    O       CH.sub.3                                                                              H    H    CH.sub.3                                                                              CH.sub.3                                                                              CH                                CH    O       CH.sub.3                                                                              H    H    OCH.sub.3                                                                             OCH.sub.3                                                                             N                                 CH    O       CH.sub.3                                                                              H    H    OCH.sub.3                                                                             CH.sub.3                                                                              N                                 CH    O       CH.sub.3                                                                              H    H    OC.sub.2 H.sub.5                                                                      NHCH.sub.3                                                                            N                                 CH    O       CH.sub.3                                                                              H    CH.sub.3                                                                            OCH.sub.3                                                                             CH.sub.3                                                                              N                                 N     O       CH.sub.3                                                                              H    H    OCH.sub.3                                                                             OCH.sub.3                                                                             CH                                N     O       CH.sub.3                                                                              H    H    OCH.sub.3                                                                             CH.sub.3                                                                              CH                                N     O       CH.sub.3                                                                              H    H    Cl     OCH.sub.3                                                                             CH                                N     O       CH.sub.3                                                                              H    H    CH.sub.3                                                                              CH.sub.3                                                                              CH                                N     O       CH.sub.3                                                                              H    H    OCH.sub.3                                                                             OCH.sub.3                                                                             N                                 N     O       CH.sub.3                                                                              H    H    OCH.sub.3                                                                             CH.sub.3                                                                              N                                 N     O       CH.sub.3                                                                              H    H    OC.sub.2 H.sub.5                                                                      NHCH.sub.3                                                                            N                                 N     O       CH.sub.3                                                                              H    CH.sub.3                                                                            OCH.sub.3                                                                             CH.sub.3                                                                              N                                 CH    S       CH.sub.3                                                                              H    H    OCH.sub.3                                                                             OCH.sub.3                                                                             CH                                CH    S       CH.sub.3                                                                              H    H    OCH.sub.3                                                                             CH.sub.3                                                                              CH                                CH    S       CH.sub.3                                                                              H    H    Cl     OCH.sub.3                                                                             CH                                CH    S       CH.sub.3                                                                              H    H    CH.sub.3                                                                              CH.sub.3                                                                              CH                                CH    S       CH.sub.3                                                                              H    H    OCH.sub. 3                                                                            OCH.sub.3                                                                             N                                 CH    S       CH.sub.3                                                                              H    H    OCH.sub.3                                                                             CH.sub.3                                                                              N                                 CH    S       CH.sub.3                                                                              H    H    OC.sub.2 H.sub.5                                                                      NHCH.sub.3                                                                            N                                 CH    S       CH.sub.3                                                                              H    CH.sub.3                                                                            OCH.sub.3                                                                             CH.sub.3                                                                              N                                 CH    O       H      CH.sub.3                                                                            H    OCH.sub.3                                                                             OCH.sub.3                                                                             CH                                CH    O       H      CH.sub.3                                                                            H    OCH.sub.3                                                                             CH.sub.3                                                                              CH                                CH    O       H      CH.sub.3                                                                            H    Cl     OCH.sub.3                                                                             CH                                CH    O       H      CH.sub.3                                                                            H    CH.sub.3                                                                              CH.sub.3                                                                              CH                                CH    O       H      CH.sub.3                                                                            H    OCH.sub.3                                                                             OCH.sub.3                                                                             N                                 CH    O       H      CH.sub.3                                                                            H    OCH.sub.3                                                                             CH.sub.3                                                                              N                                 CH    O       H      CH.sub.3                                                                            H    OC.sub.2 H.sub.5                                                                      NHCH.sub.3                                                                            N                                 CH    O       H      CH.sub.3                                                                            CH.sub.3                                                                            OCH.sub.3                                                                             CH.sub.3                                                                              N                                 N     O       H      CH.sub.3                                                                            H    OCH.sub.3                                                                             OCH.sub.3                                                                             CH                                N     O       H      CH.sub.3                                                                            H    OCH.sub.3                                                                             CH.sub.3                                                                              CH                                N     O       H      CH.sub.3                                                                            H    Cl     OCH.sub.3                                                                             CH                                N     O       H      CH.sub.3                                                                            H    CH.sub.3                                                                              CH.sub.3                                                                              CH                                N     O       H      CH.sub.3                                                                            H    OCH.sub.3                                                                             OCH.sub.3                                                                             N                                 N     O       H      CH.sub.3                                                                            H    OCH.sub.3                                                                             CH.sub.3                                                                              N                                 N     O       H      CH.sub.3                                                                            H    OC.sub.2 H.sub.5                                                                      NHCH.sub.3                                                                            N                                 N     O       H      CH.sub.3                                                                            CH.sub.3                                                                            OCH.sub.3                                                                             CH.sub.3                                                                              N                                 CH    S       H      CH.sub.3                                                                            H    OCH.sub.3                                                                             OCH.sub.3                                                                             CH                                CH    S       H      CH.sub.3                                                                            H    OCH.sub.3                                                                             CH.sub.3                                                                              CH                                CH    S       H      CH.sub.3                                                                            H    Cl     OCH.sub.3                                                                             CH                                CH    S       H      CH.sub.3                                                                            H    CH.sub.3                                                                              CH.sub.3                                                                              CH                                CH    S       H      CH.sub.3                                                                            H    OCH.sub.3                                                                             OCH.sub.3                                                                             N                                 CH    S       H      CH.sub.3                                                                            H    OCH.sub.3                                                                             CH.sub.3                                                                              N                                 CH    S       H      CH.sub.3                                                                            H    OC.sub.2 H.sub.5                                                                      NHCH.sub.3                                                                            N                                 CH    S       H      CH.sub.3                                                                            CH.sub.3                                                                            OCH.sub.3                                                                             CH.sub.3                                                                              N                                 CH    O       H      H    H    OCH.sub.3                                                                             OCH.sub.3                                                                             CH                                CH    O       H      H    H    OCH.sub.3                                                                             CH.sub.3                                                                              CH                                CH    O       H      H    H    Cl     OCH.sub.3                                                                             CH                                CH    O       H      H    H    CH.sub.3                                                                              CH.sub.3                                                                              CH                                CH    O       H      H    H    OCH.sub.3                                                                             OCH.sub.3                                                                             N                                 CH    O       H      H    H    OCH.sub.3                                                                             CH.sub.3                                                                              N                                 CH    O       H      H    H    OC.sub.2 H.sub.5                                                                      NHCH.sub.3                                                                            N                                 CH    O       H      H    CH.sub.3                                                                            OCH.sub.3                                                                             CH.sub.3                                                                              N                                 N     O       H      H    H    OCH.sub.3                                                                             OCH.sub.3                                                                             CH                                N     O       H      H    H    OCH.sub.3                                                                             CH.sub.3                                                                              CH                                N     O       H      H    H    Cl     OCH.sub.3                                                                             CH                                N     O       H      H    H    CH.sub.3                                                                              CH.sub.3                                                                              CH                                N     O       H      H    H    OCH.sub.3                                                                             OCH.sub.3                                                                             N                                 N     O       H      H    H    OCH.sub.3                                                                             CH.sub.3                                                                              N                                 N     O       H      H    H    OC.sub.2 H.sub.5                                                                      NHCH.sub.3                                                                            N                                 N     O       H      H    CH.sub.3                                                                            OCH.sub.3                                                                             CH.sub.3                                                                              N                                 CH    S       H      H    H    OCH.sub.3                                                                             OCH.sub.3                                                                             CH                                CH    S       H      H    H    OCH.sub.3                                                                             CH.sub.3                                                                              CH                                CH    S       H      H    H    Cl     OCH.sub.3                                                                             CH                                CH    S       H      H    H    CH.sub.3                                                                              CH.sub.3                                                                              CH                                CH    S       H      H    H    OCH.sub.3                                                                             OCH.sub.3                                                                             N                                 CH    S       H      H    H    OCH.sub.3                                                                             CH.sub.3                                                                              N                                 CH    S       H      H    H    OC.sub.2 H.sub.5                                                                      NHCH.sub.3                                                                            N                                 CH    S       H      H    CH.sub.3                                                                            OCH.sub.3                                                                             CH.sub.3                                                                              N                                 N     S       CH.sub.3                                                                              CH.sub.3                                                                            H    OCH.sub.3                                                                             OCH.sub.3                                                                             CH                                N     S       CH.sub.3                                                                              CH.sub.3                                                                            H    OCH.sub.3                                                                             CH.sub.3                                                                              CH                                N     S       CH.sub.3                                                                              CH.sub.3                                                                            H    Cl     OCH.sub.3                                                                             CH                                N     S       CH.sub.3                                                                              CH.sub.3                                                                            H    CH.sub.3                                                                              CH.sub.3                                                                              CH                                N     S       CH.sub.3                                                                              CH.sub.3                                                                            H    OCH.sub.3                                                                             OCH.sub.3                                                                             N                                 N     S       CH.sub.3                                                                              CH.sub.3                                                                            H    OCH.sub.3                                                                             CH.sub.3                                                                              N                                 N     S       CH.sub.3                                                                              CH.sub.3                                                                            H    OC.sub.2 H.sub.5                                                                      NHCH.sub.3                                                                            N                                 N     S       CH.sub.3                                                                              CH.sub.3                                                                            CH.sub.3                                                                            OCH.sub.3                                                                             CH.sub.3                                                                              N                                 CH    NCH.sub.3                                                                              CH.sub.3                                                                              CH.sub.3                                                                            H    OCH.sub.3                                                                             OCH.sub.3                                                                             CH                                CH    NCH.sub.3                                                                              CH.sub.3                                                                              CH.sub.3                                                                            H    OCH.sub.3                                                                             CH.sub.3                                                                              CH                                CH    NCH.sub.3                                                                              CH.sub.3                                                                              CH.sub.3                                                                            H    Cl     OCH.sub.3                                                                             CH                                CH    NCH.sub.3                                                                              CH.sub.3                                                                              CH.sub.3                                                                            H    CH.sub.3                                                                              CH.sub.3                                                                              CH                                CH    NCH.sub.3                                                                              CH.sub.3                                                                              CH.sub.3                                                                            H    OCH.sub.3                                                                             OCH.sub.3                                                                             N                                 CH    NCH.sub.3                                                                              CH.sub.3                                                                              CH.sub.3                                                                            H    OCH.sub.3                                                                             CH.sub.3                                                                              N                                 CH    NCH.sub.3                                                                              CH.sub.3                                                                              CH.sub.3                                                                            H    OC.sub.2 H.sub.5                                                                      NHCH.sub.3                                                                            N                                 CH    NCH.sub.3                                                                              CH.sub.3                                                                              CH.sub.3                                                                            CH.sub.3                                                                            OCH.sub. 3                                                                            CH.sub.3                                                                              N                                 N     NCH.sub.3                                                                              CH.sub.3                                                                              CH.sub.3                                                                            H    OCH.sub.3                                                                             OCH.sub.3                                                                             CH                                N     NCH.sub.3                                                                              CH.sub.3                                                                              CH.sub.3                                                                            H    OCH.sub.3                                                                             CH.sub.3                                                                              CH                                N     NCH.sub.3                                                                              CH.sub.3                                                                              CH.sub.3                                                                            H    Cl     OCH.sub.3                                                                             CH                                N     NCH.sub.3                                                                              CH.sub.3                                                                              CH.sub.3                                                                            H    CH.sub.3                                                                              CH.sub.3                                                                              CH                                N     NCH.sub.3                                                                              CH.sub.3                                                                              CH.sub.3                                                                            H    OCH.sub.3                                                                             OCH.sub.3                                                                             N                                 N     NCH.sub.3                                                                              CH.sub.3                                                                              CH.sub.3                                                                            H    OCH.sub.3                                                                             CH.sub.3                                                                              N                                 N     NCH.sub.3                                                                              CH.sub.3                                                                              CH.sub.3                                                                            H    OC.sub.2 H.sub.5                                                                      NHCH.sub.3                                                                            N                                 N     NCH.sub.3                                                                              CH.sub.3                                                                              CH.sub.3                                                                            CH.sub.3                                                                            OCH.sub.3                                                                             CH.sub.3                                                                              N                                 N     S       H      CH.sub.3                                                                            H    OCH.sub.3                                                                             OCH.sub.3                                                                             CH                                N     S       H      CH.sub.3                                                                            H    OCH.sub.3                                                                             CH.sub.3                                                                              CH                                N     S       H      CH.sub.3                                                                            H    Cl     OCH.sub.3                                                                             CH                                N     S       H      CH.sub.3                                                                            H    CH.sub.3                                                                              CH.sub.3                                                                              CH                                N     S       H      CH.sub.3                                                                            H    OCH.sub.3                                                                             OCH.sub.3                                                                             N                                 N     S       H      CH.sub.3                                                                            H    OCH.sub.3                                                                             CH.sub.3                                                                              N                                 N     S       H      CH.sub.3                                                                            H    OC.sub.2 H.sub.5                                                                      NHCH.sub.3                                                                            N                                 N     S       H      CH.sub.3                                                                            CH.sub.3                                                                            OCH.sub.3                                                                             CH.sub.3                                                                              N                                 CH    NCH.sub.3                                                                              H      CH.sub.3                                                                            H    OCH.sub.3                                                                             OCH.sub.3                                                                             CH                                CH    NCH.sub.3                                                                              H      CH.sub.3                                                                            H    OCH.sub.3                                                                             CH.sub.3                                                                              CH                                CH    NCH.sub.3                                                                              H      CH.sub.3                                                                            H    Cl     OCH.sub.3                                                                             CH                                CH    NCH.sub.3                                                                              H      CH.sub.3                                                                            H    CH.sub.3                                                                              CH.sub.3                                                                              CH                                CH    NCH.sub.3                                                                              H      CH.sub.3                                                                            H    OCH.sub.3                                                                             OCH.sub.3                                                                             N                                 CH    NCH.sub.3                                                                              H      CH.sub.3                                                                            H    OCH.sub.3                                                                             CH.sub.3                                                                              N                                 CH    NCH.sub.3                                                                              H      CH.sub.3                                                                            H    OC.sub.2 H.sub.5                                                                      NHCH.sub.3                                                                            N                                 CH    NCH.sub.3                                                                              H      CH.sub.3                                                                            CH.sub.3                                                                            OCH.sub.3                                                                             CH.sub.3                                                                              N                                 N     NCH.sub.3                                                                              H      CH.sub.3                                                                            H    OCH.sub.3                                                                             OCH.sub.3                                                                             CH                                N     NCH.sub.3                                                                              H      CH.sub.3                                                                            H    OCH.sub.3                                                                             CH.sub.3                                                                              CH                                N     NCH.sub.3                                                                              H      CH.sub.3                                                                            H    Cl     OCH.sub.3                                                                             CH                                N     NCH.sub.3                                                                              H      CH.sub.3                                                                            H    CH.sub.3                                                                              CH.sub.3                                                                              CH                                N     NCH.sub.3                                                                              H      CH.sub.3                                                                            H    OCH.sub.3                                                                             OCH.sub.3                                                                             N                                 N     NCH.sub.3                                                                              H      CH.sub.3                                                                            H    OCH.sub.3                                                                             CH.sub.3                                                                              N                                 N     NCH.sub.3                                                                              H      CH.sub.3                                                                            H    OC.sub.2 H.sub.5                                                                      NHCH.sub.3                                                                            N                                 N     NCH.sub.3                                                                              H      CH.sub.3                                                                            CH.sub.3                                                                            OCH.sub.3                                                                             CH.sub.3                                                                              N                                 N     S       H      H    H    OCH.sub.3                                                                             OCH.sub.3                                                                             CH                                N     S       H      H    H    OCH.sub.3                                                                             CH.sub.3                                                                              CH                                N     S       H      H    H    Cl     OCH.sub.3                                                                             CH                                N     S       H      H    H    CH.sub.3                                                                              CH.sub.3                                                                              CH                                N     S       H      H    H    OCH.sub.3                                                                             OCH.sub.3                                                                             N                                 N     S       H      H    H    OCH.sub.3                                                                             CH.sub.3                                                                              N                                 N     S       H      H    H    OC.sub.2 H.sub.5                                                                      NHCH.sub.3                                                                            N                                 N     S       H      H    CH.sub.3                                                                            OCH.sub.3                                                                             CH.sub.3                                                                              N                                 CH    NCH.sub.3                                                                              H      H    H    OCH.sub.3                                                                             OCH.sub.3                                                                             CH                                CH    NCH.sub.3                                                                              H      H    H    OCH.sub.3                                                                             CH.sub.3                                                                              CH                                CH    NCH.sub.3                                                                              H      H    H    Cl     OCH.sub.3                                                                             CH                                CH    NCH.sub.3                                                                              H      H    H    CH.sub.3                                                                              CH.sub.3                                                                              CH                                CH    NCH.sub.3                                                                              H      H    H    OCH.sub.3                                                                             OCH.sub.3                                                                             N                                 CH    NCH.sub.3                                                                              H      H    H    OCH.sub.3                                                                             CH.sub.3                                                                              N                                 CH    NCH.sub.3                                                                              H      H    H    OC.sub.2 H.sub.5                                                                      NHCH.sub.3                                                                            N                                 CH    NCH.sub.3                                                                              H      H    CH.sub.3                                                                            OCH.sub.3                                                                             CH.sub.3                                                                              N                                 N     NCH.sub.3                                                                              H      H    H    OCH.sub.3                                                                             OCH.sub.3                                                                             CH                                N     NCH.sub.3                                                                              H      H    H    OCH.sub.3                                                                             CH.sub.3                                                                              CH                                N     NCH.sub.3                                                                              H      H    H    Cl     OCH.sub.3                                                                             CH                                N     NCH.sub.3                                                                              H      H    H    CH.sub.3                                                                              CH.sub.3                                                                              CH                                N     NCH.sub.3                                                                              H      H    H    OCH.sub.3                                                                             OCH.sub.3                                                                             N                                 N     NCH.sub.3                                                                              H      H    H    OCH.sub.3                                                                             CH.sub.3                                                                              N                                 N     NCH.sub.3                                                                              H      H    H    OC.sub.2 H.sub.5                                                                      NHCH.sub.3                                                                            N                                 N     NCH.sub.3                                                                              H      H    CH.sub.3                                                                            OCH.sub.3                                                                             CH.sub.3                                                                              N                                 N     S       CH.sub.3                                                                              H    H    OCH.sub.3                                                                             OCH.sub.3                                                                             CH                                N     S       CH.sub.3                                                                              H    H    OCH.sub.3                                                                             CH.sub.3                                                                              CH                                N     S       CH.sub.3                                                                              H    H    Cl     OCH.sub.3                                                                             CH                                N     S       CH.sub.3                                                                              H    H    CH.sub.3                                                                              CH.sub.3                                                                              CH                                N     S       CH.sub.3                                                                              H    H    OCH.sub.3                                                                             OCH.sub.3                                                                             N                                 N     S       CH.sub.3                                                                              H    H    OCH.sub.3                                                                             CH.sub.3                                                                              N                                 N     S       CH.sub.3                                                                              H    H    OC.sub.2 H.sub.5                                                                      NHCH.sub.3                                                                            N                                 N     S       CH.sub.3                                                                              H    CH.sub.3                                                                            OCH.sub.3                                                                             CH.sub.3                                                                              N                                 CH    NCH.sub.3                                                                              CH.sub.3                                                                              H    H    OCH.sub.3                                                                             OCH.sub.3                                                                             CH                                CH    NCH.sub.3                                                                              CH.sub.3                                                                              H    H    OCH.sub.3                                                                             CH.sub.3                                                                              CH                                CH    NCH.sub.3                                                                              CH.sub.3                                                                              H    H    Cl     OCH.sub.3                                                                             CH                                CH    NCH.sub.3                                                                              CH.sub.3                                                                              H    H    CH.sub.3                                                                              CH.sub.3                                                                              CH                                CH    NCH.sub.3                                                                              CH.sub.3                                                                              H    H    OCH.sub.3                                                                             OCH.sub.3                                                                             N                                 CH    NCH.sub.3                                                                              CH.sub.3                                                                              H    H    OCH.sub.3                                                                             CH.sub.3                                                                              N                                 CH    NCH.sub.3                                                                              CH.sub.3                                                                              H    H    OC.sub.2 H.sub.5                                                                      NHCH.sub.3                                                                            N                                 CH    NCH.sub.3                                                                              CH.sub.3                                                                              H    CH.sub.3                                                                            OCH.sub.3                                                                             CH.sub.3                                                                              N                                 N     NCH.sub.3                                                                              CH.sub.3                                                                              H    H    OCH.sub.3                                                                             OCH.sub.3                                                                             CH                                N     NCH.sub.3                                                                              CH.sub.3                                                                              H    H    OCH.sub.3                                                                             CH.sub.3                                                                              CH                                N     NCH.sub.3                                                                              CH.sub.3                                                                              H    H    Cl     OCH.sub.3                                                                             CH                                N     NCH.sub.3                                                                              CH.sub.3                                                                              H    H    CH.sub.3                                                                              CH.sub.3                                                                              CH                                N     NCH.sub.3                                                                              CH.sub.3                                                                              H    H    OCH.sub.3                                                                             OCH.sub.3                                                                             N                                 N     NCH.sub.3                                                                              CH.sub.3                                                                              H    H    OCH.sub.3                                                                             CH.sub.3                                                                              N                                 N     NCH.sub.3                                                                              CH.sub.3                                                                              H    H    OC.sub.2 H.sub.5                                                                      NHCH.sub.3                                                                            N                                 N     NCH.sub.3                                                                              CH.sub.3                                                                              H    CH.sub.3                                                                            OCH.sub.3                                                                             CH.sub.3                                                                              N                                 ______________________________________                                    

Formulations

Useful formulations of the compounds of Formula I can be prepared in conventional ways. They include dusts, granules, pellets, solutions, suspensions, emulsions, wettable powders, emulsifiable concentrates and the like. Many of these may be applied directly. Sprayable formulations can be extended in suitable media and used at spray volumes of from a few liters to several hundred liters per hectare. High strength compositions are primarily used as intermediates for further formulation. The formulations, broadly, contain about 0.1% to 99% by weight of active ingredient(s) and at least one of (a) about 0.1% to 20% surfactant(s). More specifically, they will contain these ingredients in the following approximate proportions:

    ______________________________________                                                     Weight Percent*                                                                Active                                                                         Ingredients                                                                            Diluent (s)                                                                              Surfactant (s)                                   ______________________________________                                         Wettable powders                                                                             20-90      0-74     1-10                                         Oil Suspensions,                                                                              3-50     40-95     0-15                                         Emulsions, Solutions,                                                          (including Emulsifiable                                                        Concentrates)                                                                  Aqueous Suspension                                                                           10-50     40-84     1-20                                         Dusts          1-25     70-99     0-5                                          Granules and Pellets                                                                         0.1-95      5-99.9  0-15                                         High Strength 90-99      0-10     0-2                                          Compositions                                                                   ______________________________________                                          *Active ingredient plus at least one of a Surfactant of a Diluent equals       100 weight percent.                                                      

Lower or higher levels of active ingredient can, of course, be present depending on the intended use of the physical properties of the compound. Higher ratios of surfactant to active ingredient are sometimes desirable, and are achieved by incorporation into the formulation or by tank mixing.

Typical solid diluents are described in Watkins, et al., "Handbook of Insecticide Dust Diluents and Carriers", 2nd Ed., Dorland Books, Caldwell, N.J., but other solids, either mined or manufactered, may be used. The more absorptive diluents are preferred for wettable powders and the denser ones for dusts. Typical liquid diluents and solvents are described in Marsden, "Solvents Guide," 2nd Ed., Interscience, New York, 1985. Solubility under 0.1% is preferred for suspension concentrates; solution concentrates are preferably stable against phase separation at 0° C. "McCutcheon's Detergents and Emulsifiers Annual", MC Publishing Corp., Ridgewood, N.J., as well as Sisely and Wood, "Encyclopedia of Surface Active Agents", Chemical Publishing Co., Inc., New York, 1964, list surfactants and recommended uses. All formulations can contain minor amounts of additives to reduce foaming, caking, corrosion, microbiological growth, etc.

The methods of making such compositions are well known. Solutions are prepared by simply mixing the ingredients. Fine solid compositions are made by blending and, usually, grinding as in a hammer or fluid energy mill. Suspensions are prepared by wet milling (see, for example, Littler, U.S. Pat. No. 3,060,084). Granules and pellets may be made by spraying the active material upon preformed granular carriers or by agglomeration techniques. See J. E. Browning, "Agglomeration", Chemical Engineering, Dec. 4, 1967, pp. 147ff. and "Perry's Chemical Engineer's Handbook", 5th ed., McGraw-Hill, New York, 1973, pp. 8-57ff.

For further information regarding the art of formulation, see for example:

H. M. Loux, U.S. Pat. No. 3,235,361, Feb. 15, 1966, Col. 6, line 16 through Col. 7, line 19 and Examples 10 through 41;

R. W. Luchenbaugh, U.S. Pat. No. 3,309,192, Mar. 14, 1967, Col. 5, line 43 through Col. 7, line 62 and Examples 8, 12, 15, 39, 41, 52, 53, 58, 132, 138-140, 162-164, 166, 167 and 169-182;

H. Gysin and E. Knusli, U.S. Pat. No. 2,891,855, June 23, 1959, Col. 3, line 66 through Col. 5, line 17 and Examples 1-4;

G. C. Klingman, "Weed Control as a Science", John Wiley and Sons, Inc., New York, 1961, pp. 81-96; and

J. D. Fryer and S. A. Evans, "Weed Control Handbook", 5th ed., Blackwell Scientific Publications, Oxford, 1968, pp. 101-103.

In the following examples, all parts are by weight unless otherwise indicated.

EXAMPLE 1 Wettable Powder

    ______________________________________                                         N-[[(4,6-dimethoxy-2-pyrimidinyl)amino]carbonyl]-                                                        80%                                                  2,4-dimethylpyrazolo[1,5-a] -1,3,5-triazine-8-                                 sulfonamide                                                                    sodium alkylnaphthalenesulfonate                                                                         2%                                                   sodium ligninsulfonate    2%                                                   synthetic amorphous silica                                                                               3%                                                   kaolinite                 13%                                                  ______________________________________                                    

The ingredients are blended, hammer-milled until all the solids are essentially under 50 microns, reblended, and packaged.

EXAMPLE 2 Wettable Powder

    ______________________________________                                         N-[[(4-methoxy-6-methyl-2-pyrimidinyl)amino]carbonyl]-                                                      50%                                               isoxazolo[4,5-b] pyridine-3-sulfonamide                                        sodium alkylnaphthalenesulfonate                                                                             2%                                               low viscosity methyl cellulose                                                                               2%                                               diatomaceous earth           46%                                               ______________________________________                                    

The ingredients are blended, coarsely hammer-milled and then air-milled to produce particles essentially all below 10 microns in diameter. The product is reblended before packaging.

EXAMPLE 3 Granule

    ______________________________________                                         Wettable Powder of Example 2                                                                           5%                                                     attapulgite granules   95%                                                     (U.S.S. 20-40 mesh; 0.84-0.42 mm)                                              ______________________________________                                    

A slurry of wettable powder containing 25% solids is sprayed on the surfact of attapulgite granules in a double-cone blender. The granules are dried and packaged.

EXAMPLE 4 Extruded Pellet

    ______________________________________                                         N-[[(4,6-dimethoxy-2-pyrimidinyl)amino]carbonyl]-                                                          25%                                                2,4-dimethylpyrazolo[1,5-a] -1,3,5-triazine-8-                                 sulfonamide                                                                    anhydrous sodium sulfate    10%                                                crude calcium ligninsulfonate                                                                               5%                                                sodium alkylnaphthalenesulfonate                                                                            1%                                                calcium/magnesium bentonite 59%                                                ______________________________________                                    

The ingredients are blended, hammer-milled and then moistened with about 12% water. The mixture is extruded as cylinders about 3 mm diameter which are cut to produce pellets about 3 mm long. These may be used directly after drying, or the dried pellets may be crushed to pass a U.S. Ser. No. 20 sieve (0.84 MM openings). The granules held on a U.S. Ser. No. 40 sieve (0.42 mm openings) may be packaged for use and the fines recycled.

EXAMPLE 5 Oil Suspension

    ______________________________________                                         N-[[(4-methoxy-6-methyl-2-pyrimidinyl)amino]carbonyl]-                                                      25%                                               isoxazolo[4,5-b] pyridine-3-sulfonamide                                        polyoxyethylene sorbitol hexaoleate                                                                          5%                                               highly aliphatic hydrocarbon oil                                                                            70%                                               ______________________________________                                    

The ingredients are ground together in a sand mill until the solid particles have been reduced to under about 5 microns. The resulting thick suspension may be applied directly, but preferably after being extended with oils or emulsified in water.

EXAMPLE 6 Wettable Powder

    ______________________________________                                         N-[[(4,6-dimethoxy-2-pyrimidinyl)amino]carbonyl]-                                                        20%                                                  2,4-dimethylpyrazolo[1,5-a] -1,3,5-triazine-8-                                 sulfonamide                                                                    sodium alkylnaphthalenesulfonate                                                                         4%                                                   sodium ligninsulfonate    4%                                                   low viscosity methyl cellulose                                                                           3%                                                   attapulgite               69%                                                  ______________________________________                                    

The ingredients are thoroughly blended. After grinding in a hammer-mill to produce particles essentially all below 100 microns, the material is reblended and sifted through a U.S. Ser. No. 50 sieve (0.3 mm opening) and packaged.

EXAMPLE 7 Low Strength Granule

    ______________________________________                                         N-[[(4-methoxy-6-methyl-2-pyrimidinyl)amino]carbonyl]-                                                      1%                                                isoxazolo[4,5-b] pyridine-3-sulfonamide                                        N,N-dimethylformamide        9%                                                attapulgite granules         90%                                               (U.S.S. 20-2-40 sieve)                                                         ______________________________________                                    

The active ingredient is dissolved in the solvent and the solution is sprayed upon dedusted granules in a double cone blender. After spraying of the solution has been completed, the blender is allowed to run for a short period and then the granules are packaged.

EXAMPLE 8 Aqueous Suspension

    ______________________________________                                         N-[[(4,6-dimethoxy-2-pyrimidinyl)amino]carbonyl]-                                                          40%                                                2,4-dimethylpyrazolo[1,5-a] -1,3,5-triazine-8-                                 sulfonamide                                                                    polyacrylic acid thickener  0.3%                                               dodecylphenol polyethylene glycol ether                                                                    0.5%                                               disodium phosphate          1%                                                 monosodium phosphate        0.5%                                               polyvinyl alcohol           1.0%                                               water                       56.7%                                              ______________________________________                                    

The ingredients are blended and ground together in a sand mill to produce particles essentially all under 5 microns in size.

EXAMPLE 9 Solution

    ______________________________________                                         N-[[(4-methoxy-6-methyl-2-pyrimidinyl)amino]carbonyl]-                                                       5%                                               isoxazolo[4,5-b] pyridine-3-sulfonamide                                        water                        95%                                               ______________________________________                                    

The salt is added directly to the water with stirring to produce the solution, which may then be package for use.

EXAMPLE 10 Low Strength Granule

    ______________________________________                                         N-[[(4,6-dimethoxy-2-pyrimidinyl)amino]carbonyl]-                                                        0.1%                                                 2,4-dimethylpyrazolo[1,5-a] -1,3,5-triazine-8-                                 sulfonamide                                                                    attapulgite granules      99.9%                                                (U.S.S. 20-40 mesh)                                                            ______________________________________                                    

The active ingredient is dissolved in a solvent and the solution is sprayed upon dedusted granules in a double-cone blender. After spraying of the solution has been completed, the material is warmed to evaporate the solvent. The material is allowed to cool and then packaged.

EXAMPLE 11 Granule

    ______________________________________                                         N-[[(4-methoxy-6-methyl-2-pyrimidinyl)amino]carbonyl]-                                                      80%                                               isoxazolo[4,5-b] pyridine-3-sulfonamide                                        wetting agent                 1%                                               crude ligninsulfonate salt (containing                                                                      10%                                               5-20% of the natural sugars)                                                   attapulgite clay              9%                                               ______________________________________                                    

The ingredients are blended and milled to pass through a 100 mesh screen. This material is then added to a fluid bed granulator, the air flow is adjusted to gently fluidize the material, and a fine spray of water is sprayed onto the fluidized material. The fluidization and spraying are continued until granules of the desired size range are made. The spraying is stopped, but fluidization is continued, optionally with heat, until the water content is reduced to the desired level, generally less than 1%. The material is then discharged, screened to the desired size range, generally 14-100 mesh (1410-149 microns), and packaged for use.

EXAMPLE 12 High Strength Concentrate

    ______________________________________                                         N-[[(4,6-dimethoxy-2-pyrimidinyl)amino]carbonyl]-                                                         99%                                                 2,4-dimethylpyrazolo[1,5-a] -1,3,5-triazine-8-                                 sulfonamide                                                                    silica aerogel            0.5%                                                 synthetic amorphous silica                                                                               0.5%                                                 ______________________________________                                    

The ingredients are blended and ground in a hammer-mill to produce a material essentially all passing a U.S. Ser. No. 50 screen (0.3 mm opening). The concentrate may be formulated further if necessary.

EXAMPLE 13 Wettable Powder

    ______________________________________                                         N-[[(4-methoxy-6-methyl-2-pyrimidinyl)amino]carbonyl]-                                                      90%                                               isoxazolo[4,5-b] pyridine-3-sulfonamide                                        dioctyl sodium sulfosuccinate                                                                              0.1%                                               synthetic fine silica       9.9%                                               ______________________________________                                    

The ingredients are blended and ground in a hammer-mill to produce particles essentially all below 100 microns. The material is sifted through a U.S.S. No. 50 screen and then packaged.

EXAMPLE 14 Wettable Powder

    ______________________________________                                         N-[[(4,6-dimethoxy-2-pyrimidinyl)amino]carbonyl]-                                                          40%                                                2,4-dimethylpyrazolo[1,5-a] -1,3,5-triazine-8-                                 sulfonamide                                                                    sodium ligninsulfonate      20%                                                montmorillonite clay        40%                                                ______________________________________                                    

The ingredients are thoroughly blended, coarsely hammer-milled and then air-milled to produce particles essentially all blow 10 microns in size. The material is reblended and then packaged.

EXAMPLE 15 Oil Suspension

    ______________________________________                                         N-[[(4-methoxy-6-methyl-2-pyrimidinyl)amino]carbonyl]-                                                      35%                                               isoxazolo[4,5-b] pyridine-3-sulfonamide                                        blend of polyalcohol carboxylic                                                                              6%                                               esters and oil soluble petroleum                                               sulfonates                                                                     xylene                       59%                                               ______________________________________                                    

The ingredients are combined and ground together in a sand mill to produce particles essentially all below 5 microns. The product can be used directly, extended with oils, or emulsified in water.

EXAMPLE 16 Dust

    ______________________________________                                         N-[[(4,6-dimethoxy-2-pyrimidinyl)amino]carbonyl]-                                                          10%                                                2,4-dimethylpyrazolo[1,5-a] -1,3,5-triazine-8-                                 sulfonamide                                                                    attapulgite                 10%                                                Pyrophyllite                80%                                                ______________________________________                                    

The active ingredient is blended with attapulgite and then passed through a hammer-mill to produce particles substantially all below 200 microns. The ground concentrate is then blended with powdered pyrophyllite until homogeneous.

EXAMPLE 17 Emulsifiable Concentrate

    ______________________________________                                         N-[[(4-methoxy-6-methyl-2-pyrimidinyl)amino]carbonyl]-                                                      10%                                               isoxazolo[4,5-b] pyridine-3-sulfonamide                                        chlorobenzene                84%                                               sorbitan monostearate and polyoxyethylene                                                                    6%                                               condensates thereof                                                            ______________________________________                                    

The ingredients are combined and stirred to produce a solution which can be emulsified in water for application.

Utility

The compounds of the present invention are expected to be active preemergent or postemergent herbicides or plant growth regulants. The rates of application for the compounds of the invention are determined by a number of factors, including their use as plant growth modifiers or as herbicides, the crop species involved, the types of weeds to be controlled, weather and climate, formulations selected, mode of application, amount of foliage present, etc. In general terms, the subject compounds should be applied at levels of around 0.001 to 20 kg/ha, the lower rates being suggested for use on lighter soils and/or those having a low organic matter content, for plant growth modification or for situations where only short-term persistence is required, such as a herbicide for fallow land.

The compounds of the invention may be used in combination with any other commercial herbicide, nonlimiting examples of which are listed below:

    ______________________________________                                         Common Name                                                                              Chemical Name                                                        ______________________________________                                         acetochlor                                                                               2-chloro-N-(ethoxymethyl)-N-(2-ethyl-6-                                        methylphenyl)acetamide                                               acifluorfen                                                                              5-[2-chloro-4-(trifluoromethyl)phenoxy]-                                       2-nitrobenzoic acid                                                  acrolein  2-propenal                                                           alachlor  2-chloro-N-(2,6-diethylphenyl-N-methoxy-                                       methyl)acetamide                                                     ametryn   N-ethyl-N'(1-methylethyl-6-(methylthio-                                        1,3,5-triazine-2,4-diamine                                           amitrole  1H-1,2,4-triazol-3-amine                                             AMS       ammonium sulfamate                                                   asulam    methyl[(4-aminophenyl)sulfonyl]carbamate                             atrazine  6-chloro-N-ethyl-N'-(1-methylethyl)-1,3,5-                                     triazine-2,4-diamine                                                 barban    4-chloro-2-butynyl 3-chlorocarbamate                                 benefin   N-butyl-N-ethyl-2,6-dinitro-4-(tri-                                            fluoromethyl)benzenamine                                             bensulfuron                                                                              2-[[[[[4,6-dimethoxy-2-pyrimidinyl)amino]-                                     carbonyl]amino]sulfonyl]methyl]benzoic                                         acid                                                                 bensulide O,O-bis(1-methylethyl)S-[2-[(phenylsul-                                        fonyl)amino]ethyl]phosphorodithioate                                 bentazon  3-(1-methylethyl)-(1H)-2,2,3-benzothia-                                        diazin-4(3H)-one 2,2-dioxide                                         benzofluor                                                                               N-[4-(ethylthio)-2-(trifluoromethyl)-                                          phenyl]methanesulfonamide                                            benzoylprop                                                                              N-benzoyl-N-(3,4-dichlorophenyl)-DL-                                           alanine                                                              bifenox   methyl 5-(2,4-dichlorophenoxy)-2-                                              nitrobenzoate                                                        bromacil  5-bromo-6-methyl-3-(1-methylpropyl)-                                           2,4(1H,3H)pyrimidinedione                                            bromoxynil                                                                               3,5-dibromo-4-hydroxybenzonitrile                                    butachlor N-(butoxymethyl)-2-chloro-N-(2,6-diethyl-                                      phenyl)acetamide                                                     buthidazole                                                                              3-[5-(1,1-dimethylethyl)-1,3,4-thia-                                           diazol-2-yl]-4-hyrdroxy-1-methyl-2-                                            imidazolidinone                                                      butralin  4-(1,1-dimethylethyl)-N-(1-methyl-                                             propyl)-2,6-dinitrobenzenamine                                       butylate  S-ethyl bis(2-methylpropyl)carbamothioate                            cacodylic dimethyl arsinic oxide                                               acid                                                                           CDAA      2-chloro-N,N-di-2-propenylacetamide                                  CDEC      2-chloroallyl diethyldithiocarbamate                                 chloramben                                                                               3-amino-2,5-dichlorobenzoic acid                                     chlorbromuron                                                                            3-(4-bromo-3-chlorophenyl)-1-methoxy-1-                                        methylurea                                                           chlorimuron                                                                              2-[ [[[4-chloro-6-methoxy-2-pyrimidinyl)-                            ethyl     amino]carbonyl]amino] sulfonyl]benzoic                                         acid, ethyl ester                                                    chloroxuron                                                                              N'-[4-(4-chlorophenoxy)phenyl]-N,N-                                            dimethylurea                                                         chlorpropham                                                                             1-methyethyl 3-chlorophenylcarbamate                                 chlorsulfuron                                                                            2-chloro-N-[[(4-methoxy-6-methyl-1,3,5-                                        triazin-2-yl)amino]carbonyl]benxene-                                           sulfonamide                                                          chlortoluron                                                                             N'-(3-chloro-4-methylphenyl-N',N'-                                             dimethylurea                                                         cinmethylin                                                                              exo-1-methyl-4-(1-methylethyl)-2-[(2-                                          methylphenyl)methoxy]-7-oxabicyclo-                                            [2.2.1]heptane                                                       clethodim (E,E)-(±)-2-[1-[[(3-chloro-2-propenyl)-                                     oxy]imino]propyl]-5-[2-(ethylthio)-                                            propyl]-3-hydroxy-2-cyclohexen-1-one                                 clomazone 2-[(2-chlorophenyl)methyl]-4,4-dimethyl-                                       3-isoxazolidinone                                                    cloproxydim                                                                              (E,E)-2-[1-[[(3-chloro-2-propenyl)oxy)-                                        imino]butyl]-5-[2-(ethylthio)propyl]-                                          3-hydroxy-2-cyclohexen-1-one                                         clopyralid                                                                               3,6-dichloro-2-pyridinecarboxylic acid                               CMA       calcium salt of MAA                                                  cyanazine 2-[[4-chloro-6-(ethylamino)-1,3,5-triazin-                                     3-yl]amino]-2-methylpropanenitrile                                   cycloate  S-ethyl cyclohexanecarbamothioate                                    cycluron  3-cyclooctyl-1,1-dimethylurea                                        cyperquat 1-methyl-4-phenylpyridinium                                          cyprazine 2-chloro-4-(cyclopropylamino)-6-(iso-                                          propylamino)-s-triazine                                              cyprazole N-[5-(2-chloro-1,1-dimethylethyl)-1,3,4-                                       thiadiazol-2-yl] cyclopropanecarbox-                                           amide                                                                cypromid  3',4'-dichlorocyclopropanecarboxanilide                              dalapon   2,2-dichloropropionic acid                                           dazomet   tetrahydro-3,5-dimethyl-2H-1,3,5-thia-                                         diazine-2-thione                                                     DCPA      dimethyl 2,3,5,6-tetrachloro-1,4-benzene-                                      dicarboxylate                                                        desmediphan                                                                              ethyl [3-[[(phenylamino)carbonyl]oxy]-                                         phenyl]carbamate                                                     desmetryn 2-(isopropylamino)-4-(methylamino)-6-                                          methylthio)-s-triazine                                               diallate  S-(2,3-dichlor-2-propenyl)bis(1-                                               methylethyl)carbamothioate                                           dicamba   3,6-dichloro-2-methoxybenzoic acid                                   dichlobenil                                                                              2,6-dichlorobenzonitrile                                             dichlorprop                                                                              (±)-2-(2,4-dichlorphenoxy)propanoic                                         acid                                                                 dichlofop (±)-2-[4-(2,4-dichlorophenoxy)phenoxy]-                                     propanoic acid                                                       diethatyl N-(chloroacetyl)-N-(2,6-diethylphenyl)-                                        glycine                                                              difenzoquat                                                                              1,2-dimethyl-3,5-diphenyl-1H-pyrazolium                              dinitramine                                                                              N.sup.3,N.sup.3 -diethyl-2,4-dinitro-6-(trifluoro-                             methyl)-1,3-benzenediamine                                           dinoseb   2-(1-methylpropyl)-4,6-dinitrophenol                                 diphenamid                                                                               N,N-dimethyl-α-phenylbenzeneacetamide                          dipropetryn                                                                              6-(ethylthio)-N,N'-bis(1-methylethyl)-                                         1,3,5-triazine-2,4-diamine                                           diquat    6,7-dihydrodipyrido[1,2-α-2',1'-c]-                                      pyrazinediium ion                                                    diuron    N'-(3,4-dichlorophenyl)-N,N-dimethylurea                             DNOC      2-methyl-4,6-dinitrophenol                                           DPX-M6316 3-[[[[(4-methoxy-6-methyl-1,3,5-triazin-                                       2-yl)amino]carbonyl]amino]sulfonyl]-                                           2-thiophenecarboxylic acid, methyl                                             ester                                                                DSMA      disodium salt of MAA                                                 endothall 7-oxabicyclo[2.2.1]heptane-2,3-dicarbox-                                       ylic acid                                                            EPTC      S-ethyl dipropylcarbamothioate                                       ethalfluralin                                                                            N-ethyl-N-(2-methyl-2-propenyl)-2,6-                                           dinitro-4-(trifluoromethyl)-                                                   benzenamine                                                          ethofumesate                                                                             (±)-2-ethoxy-2,3-dihydro-3,3-dimethyl-                                      5-benzofuranyl methanesulfonate                                      Express ®                                                                            2-[[N-(4-methoxy-6-methyl-1,3,5-triazine-                                      2-yl)-N-methylaminocarbonyl]amino-                                             sulfonyl]benzoic acid, methyl ester                                  fenac     2,3,6-trichlorobenzeneacetic acid                                    fenoxaprop                                                                               (±)-2-[4-[(6-chloro-2-benzoxazolyl)oxy]-                                    phenoxy]propanoic acid                                               fenuron   N,N-dimethyl-N'-phenylurea                                           fenuron TCA                                                                              Salt of fenuron and TCA                                              flamprop  N-benzoyl-N-(3-chloro-4-fluorophenyl)-                                         DL-alanine                                                           fluazifop (±)2-[4-[[5-(trifluoromethyl)-2-pyri-                                       dinyl]oxy]phenoxy]propanoic acid                                     fluazifop-P                                                                              (R)-2-[4-[[5-trifluoromethyl)-2-pyri-                                          dinyl]oxy]phenoxy]propanoic acid                                     fluchloralin                                                                             N-(2-chloroethyl)-2,6-dinitro-N-propyl-                                        4-(trifluoromethyl)benzenamine                                       fluometuron                                                                              N,N-dimethyl-N'-(3-(trifluoromethyl)-                                          phenyl]urea                                                          fluorochlor-                                                                             3-chloro-4-(chloromethyl)-1-[3-trifluoro-                            idone     methyl)phenyl]-2-pyrrolidinone                                       fluorodifen                                                                              p-nitrophenyl α,α,α-trifluoro-2-nitro-                       p-tolyl ether                                                        fluoroglycofen                                                                           carboxymethyl 5-[2-chloro-4-(tri-                                              fluoromethyl)phenoxy]-2-nitrobenzoate                                fluridone 1-methyl-3-phenyl-5-[3-(trifluoro-                                             methyl)phenyl]-4(1H)-pyridinone                                      fomesafen 5-(2-chloro-4-trifluoromethylphenoxy)-                                         N-methylsulfonyl-2-nitrobenzamide                                    fosamine  ethyl hydrogen (aminocarbonyl)-                                                phosphate                                                            glyphosate                                                                               N-(phosphonomethyl)glycine                                           haloxyfop 2-[4-[[3-chloro-5-(trifluoromethyl)-2-                                         pyridinyl]oxy]phenoxy]propanoic acid                                 hexaflurate                                                                              potassium hexafluoroarsenate                                         hexazinone                                                                               3-cyclohexyl-6-(dimethylamino)-1-methyl-                                       1,3,5-triazine-2,4(1H,3H)-dione                                      imazametha-                                                                              6-(4-isopropyl-4-methyl-5-oxo-2-                                     benz      imidazolin-2-yl)-m-toluic acid,                                                methyl ester and 6-(4-isopropyl)-                                              4-methyl-5-oxo-2-imidazolin-2-yl-                                              p-toluic acid, methyl ester                                          imazapyr  (±)2-[4,5-dihydro-4-methyl-4-(1-methyl-                                     ethyl)-5-oxo-1H-imidazol-2-yl]-3-                                              pyridinecarboxylic acid                                              imazaquin 2-(4,5-dihydro-4-methyl-4-(1-methyl-                                           ethyl)-5-oxo-1H-imidazol-2-yl)-3-                                              quinolinecarboxylic acid                                             imazethapyr                                                                              (±)-2-[4,5-dihydro-4-methyl-4-(1-methyl-                                    ethyl)-5-oxo-1H-imidazol-2-yl]-5-                                              ethyl-3-pyridinecarboxylic acid                                      ioxynil   4-hydroxy-3,5-diiodobenzonitrile                                     isopropalin                                                                              4-(1-methylethyl)-2,6-dinitro-N,N-                                             dipropylbenzenamine                                                  isoproturon                                                                              N-(4-isopropylphenyl)-N',N'-dimethylurea                             isouron   N'-[5-(1,1-dimethyethyl)-3-isoxazolyl]-                                        N,N-dimethylurea                                                     isoxaben  N-[3-(1-ethyl-1-methylpropyl)-5-                                               isoxazolyl]-2,6-dimethoxybenzamide                                   karbutilate                                                                              3-[[(dimethylamino)carbonyl]amino]phenyl-                                      (1,1-dimethylethyl)carbamate                                         lactofen  (±)-2-ethoxy-1-methyl-2-oxoethyl-5-[2-                                      chloro-4-(trifluoromethyl)phenoxy]-                                            2-nitrobenzoate                                                      lenacil   3-cyclohexyl-6,7-dihydro-1H-cyclopenta-                                        pyrimidine-2,4(3H,5H)-dione                                          linuron   N'-(3,4-dichlorophenyl)-N-methoxy-N-                                           methylurea                                                           MAA       methylarsonic acid                                                   MAMA      monoammonium salt of MAA                                             MCPA      (4-chloro-2-methyl)phenoxy)acetic acid                               MCPB      4-(4-chloro-2-methylphenoxy)butanoic                                           acid                                                                 mecoprop  (±)-2-(4-chloro-2-methylphenoxy)-                                           propanoic acid                                                       mefluidide                                                                               N-[(2,4-dimethyl-5-[[(trifluormethyl)-                                         sulfonyl]amino]phenyl]acetamide                                      methal-   N-(2-methyl-2-propenyl)-2,6-dinitro-N-                               propalin  propyl-4-(trifluoromethyl)benzenamide                                methabenz-                                                                               1,3-dimethyl-3-(2-benzothiazolyl)urea                                thiazuron                                                                      metham    methylcarbamodithioic acid                                           methazole 2-(3,4-dichlorophenyl)-4-methyl-1,2,4-                                         oxadiazolidine-3,5-dione                                             methoxuron                                                                               N'-(3-chloro-4-methoxyphenyl)N,N-                                              dimethylurea                                                         metolachlor                                                                              2-chloro-N-(2-ethyl-6-methylphenyl)-N-                                         (2-methoxy-1-methylethyl)acetamide                                   metribuzin                                                                               4-amino-6-(1,1-dimethylethyl)-3-(methyl-                                       thio)-1,2,4-triazin-5(4H)-one                                        metsulfuron                                                                              2- [[[[(4-methoxy-6-methyl-1,3,5-triazine-                           methyl    methyl-2-yl)amino]carbonyl]amion]sul-                                          fonyl]benzoic acid, methyl ester                                     MH        1,2-dihydro-3,6-pyridazinedione                                      molinate  S-ethyl hexahydro-1H-azepine-1-carbo-                                          thioate                                                              monolinuron                                                                              3-(p-chlorophenyl)-1-methoxy-1-methyl-                                         urea                                                                 monuron   N'(4-chlorophenyl)-N,N-dimethylurea                                  monuron TCA                                                                              Salt of monuron and TCA                                              MSMA      monosodium salt of MAA                                               napropamide                                                                              N,N-diethyl-2-(1-naphthalenyloxy)-                                             propanamide                                                          naptalam  2-[(1-naphthalenylamino)carbonyl]-                                             benzoic acid                                                         neburon   1-butyl-3-(3,4-dichlorophenyl)-1-methyl-                                       urea                                                                 nitralin  4-(methylsulfonyl)-2,6-dinitro-N,N-                                            dipropylaniline                                                      nitrofen  2,4-dichloro-1-(4-nitrophenoxy)benzene                               nitrofluorfen                                                                            2-chloro-1-(4-nitrophenoxy)-4-(tri-                                            fluoromethyl)benzene                                                 norea     N,N-dimethyl-N'-(octahydro-4,7-methano-                                        1H-inden-5-yl)urea 3aα,4α,5α,7α,7a.alpha               .-                                                                             isomer                                                               norflurazon                                                                              4-chloro-5-(methylamino)-2-(3-trifluoro-                                       methyl)phenyl-3(2H)-pyridazinone                                     oryzalin  4-(dipropylamino)-3,5-dinitro-                                                 benzenesulfonamide                                                   oxadiazon 3-[2,4-dichloro-5-(1-methylethoxy)-                                            phenyl]-5-(1,1-dimethylethyl)-                                                 1,3,4-oxadiazol-2-(3H)-one                                           oxyflurofen                                                                              2-chloro-1-(3-ethoxy-4-nitrophenoxy)-4-                                        (trifluoromethyl)benzene                                             paraquat  1,1'-dimethyl-4,4'-bipyridinium ion                                  pebulate  S-propyl butylethylcarbamothioate                                    pendimethalin                                                                            N-(1-ethylpropyl)-3,4-dimethyl-2,6-                                            dinitrobenzenamine                                                   perfluidone                                                                              1,1,1-trifluoro-N-[2-methyl-4-(phenyl-                                         sulfonyl)phenyl]methanesulfonamide                                   phenmedipham                                                                             3-[(methoxycarbonyl)amino]phenyl(3-                                            methylphenyl)carbamate                                               picloram  4-amino-3,5,6-trichloro-2-pyridine-                                            carboxylic acid                                                      PPG-1013  5-(2-chloro-4-(trifluoromethyl)-                                               phenoxy)-2-nitroacetophenone                                                   oxime-0-acetic acid, methyl ester                                    procyazine                                                                               2-[[4-chloro-6-(cyclopropylamino)-1,3,5-                                       triazine-2-yl]amino]-2-methylpropane-                                          nitrile                                                              profluralin                                                                              N-(cyclopropylmethyl)-2,6-dinitro-N-propyl-4-                                  (trifluoromethyl)benzenamine                                         prometon  6-methoxy-N,N'-bis(1-methylethyl)-1,3,5-                                       triazine-2,4-diamine                                                 prometryn N,N'-bis(1-methylethyl)-6-(methylthio)-                                        1,3,5-triazine-2,4-diamine                                           pronamide 3,5-dichloro-N-(1,1-dimethyl-2-propyn-                                         yl)benzamide                                                         propachlor                                                                               2-chloro-N-(1-methylethyl)-N-                                                  phenylacetamide                                                      propanil  N-(3',4'-dichlorophenyl)propanamide                                  propazine 6-chloro-N,N'-bis(1-methylethyl)-                                              1,3,5-triazine-2,4-diamine                                           propham   1-methylethyl phenylcarbamate                                        prosulfalin                                                                              N-[[4-(dipropylamino)-3,5-dinitro-                                             phenyl]sulfonyl]-S,S-dimethylsulfil-                                           imine                                                                prynachlor                                                                               2-chloro-N-(1-methyl-2-propynyl)acet-                                          anilide                                                              pyrazon   5-amino-4-chloro-2-phenyl-3(2H)-                                               pyridazinone                                                         quizalofop                                                                               2-[4-(6-chlorquinoxalin-2-yloxy)phen-                                ethyl     oxypropanoic acid, ethyl ester                                       quizalofop                                                                               (±)-2-[4-[(6-chloro-2-quinoxalinyl)-                                        oxy]phenoxy]propanoic acid                                           secbumeton                                                                               N-ethyl-6-methoxy-N'(1-methylpropyl)-                                          1,3,5-triazine-2,4-diamine                                           sethoxydim                                                                               2-[1-(ethoxyimino)butyl]-5-[2-(ethyl-                                          thio)propyl]-3-hydroxy-2-cyclohexene-                                          1-one                                                                siduron   N-(2-methylcyclohexyl)-N"-phenylurea                                 simazine  6-chloro-N,N-'-diethyl-1,3,5-triazine-                                         2,4-diamine                                                          sulfometuron                                                                             2-[[[[(4,6-dimethyl-2-pyrimidinyl)-                                  methyl    amino]carbonyl]amino]sulfonyl]-                                                benzoic acid, methyl ester                                           TCA       trichloroacetic acid                                                 tebuthiuron                                                                              N-[5-(1,1-dimethylethyl)-1,3,4-thiadi-                                         azol-2-yl]-N,N'-dimethylurea                                         terbacil  5-chloro-3-(1,1-dimethylethyl)-6-                                              methyl-2,4(1H,3H)-pyrimidinedione                                    terbuchlor                                                                               N-(butoxymethyl)-2-chloro-N-[2-(1,1-                                           dimethylethyl)-6-methylphenyl]-                                                acetamide                                                            terbuthyl-                                                                               2-(tert-butylamino)-4-chloro-6-(ethyl-                               azine     amino)-s-triazine                                                    terbutol  2,6-di-tert-butyl-p-tolyl methylcar-                                           bamate                                                               terbutryn N-(1,1-dimethylethyl)-N'-ethyl-6-                                              (methylthio)-1,3,5-triazine-                                                   2,4-diamine                                                          thiameturon                                                                              3- [[[[(4-methoxy-6-methyl-1,3,5-                                    methyl    triazin-2-yl)amino]carbonyl]-                                                  amino]sulfonyl]-2-thiophenecarboxylic                                          acid, methyl ester                                                   thiobencarb                                                                              S-[(4-chlorophenyl)methyl]diethylcar-                                          bamothioate                                                          triallate S-(2,3,3-trichloro-2-propenyl)bis(1-                                           methylethyl)carbamothioate                                           triclopyr [(3,5,6-trichloro-2-pyridinyl)-                                                oxy]acetic acid                                                      tridiphane                                                                               1-(3,5-dichlorophenyl)-2-(2,2,2-                                               trichloroethyl)oxirane                                               trifluralin                                                                              2,6-dinitro-N,N-dipropyl-4-(tri-                                               fluoromethyl)benzenamine                                             trimeturon                                                                               1-(p-chlorophenyl)-2,3,3-trimethylpseu-                                        dourea                                                               2,4-D     (2,4-dichlorophenoxy)acetic acid                                     2,4-DB    4-(2,4-dichlorphenoxy)butanoic acid                                  vernolate S-propyl dipropylthiocarbamothioate                                  xylachlor 2-chloro-N-(2,3-dimethylphenyl)-N-                                             (1-methylethyl)acetamide                                             ______________________________________                                     

What is claimed is:
 1. A compound of the formula ##STR61## wherein L is ##STR62## R¹ is H, halogen, C₁ -C₃ alkyl, C₁ -C₃ haloalkyl, OR⁶, SR⁶, S(O)R⁶, S(O)₂ R⁶, CO₂ R⁷, C(O)NR⁸ R⁹, S(O)₂ NR¹⁰ R¹¹, C₂ -C₃ alkenyl, C₂ -C₃ haloalkenyl, C₂ -C₃ alkynyl, NO₂, CN, C(O)R¹², C(R¹³)═NOR¹⁴ or C₁ -C₂ alkyl substituted by C₁ -C₂ alkoxy, C₁ -C₂ alkylthio or CN;R² is H, C₁ -C₃ alkyl, C₁ -C₃ alkoxy, C₁ -C₂ haloalkoxy or C₁ -C₂ alkyl substituted with OCH₃, SCH₃ or CN; R³ is H, CH₃ or OCH₃ ; R⁴ is H or CH₃ ; R⁵ is H, halogen, C₁ -C₃ alkyl, C₁ -C₃ haloalkyl, OR⁶, SR⁶, S(O)R⁶, S(O)₂ R⁶, CO₂ R⁷, C(O)NR⁸ R⁹, S(O)₂ NR¹⁰ R¹¹, C₂ -C₃ alkenyl, C₂ -C₃ haloalkenyl, C₂ -C₃ alkynyl, NO₂, CN, C(O)R¹², or C₁ -C₂ alkyl substituted by C₁ -C₂ alkoxy, C₁ -C₂ alkylthio or CN; R⁶ is C₁ -C₃ alkyl, C₁ -C₃ haloalkyl, C₃ alkenyl, C₂ -C₃ haloalkenyl, propargyl, cyclopropyl, cyclopropylmethyl or --CH₂ CH₂ -- substituted by OH, C₁ -C₂ alkoxy, SH, C₁ --C₂ thioalkyl or CN; R⁷ is C₁ -C₄ alkyl, C₂ -C₃ haloalkyl, allyl, propargyl, cyclopropyl, cyclopropylmethyl, or --CH₂ CH₂ -- substituted by OH, OCH₃, SCH₃ or CN; R⁸ is H or C₁ -C₂ alkyl; R⁹ is C₁ -C₃ alkyl, C₁ -C₃ alkoxy, allyl, propargyl, cyclopropyl, CH₂ CN, CH₂ CH₂ CN or CH₂ CH₂ OCH₃ ; R¹⁰ is H or C₁ -C₃ alkyl; R¹¹ is C₁ -C₃ alkyl, C₁ -C₃ alkoxy, allyl, propargyl, cyclopropyl, cyclopropylmethyl, CH₂ CN, CH₂ CH₂ CN or CH₂ CH₂ OCH₃ ; R¹⁰ and R¹¹ can be taken together to form a ring consisting of (--CH₂ --)₄, (--CH₂ --)₅ or (--CH₂ CH₂ --)₂ O; R¹² is H, C₁ -C₃ alkyl or cyclopropyl; R¹³ is H, C₁ -C₃ alkyl, cyclopropyl, Cl, CN, OCH₃, SCH₃ or N(CH₃)₂ ; R¹⁴ is H or C₁ -C₃ alkyl; Z is N or CH; Z¹ is N, CH or CCH₃ ; Z² is O, S or NCH₃ ; Z³ is O, S or N--R¹⁵ ; R¹⁵ is H, C₁ -C₂ alkyl, C₁ -C₂ haloalkyl, CH₂ CH₂ OCH₃, CH₂ CH₂ SCH₃, CH₂ CN or CO₂ CH₃ ; W is O or S; R is H or CH₃ ; A is ##STR63## X is H, C₁ -C₄ alkyl, C₁ -C₄ alkoxy, C₁ -C₄ haloalkoxy, C₁ -C₄ haloalkyl, C₁ -C₄ haloalkylthio, C₁ -C₄ alkylthio, halogen, C₂ -C₅ alkoxyalkyl, C₂ -C₅ alkoxyalkoxy, amino, C₁ -C₃ alkylamino or di(C₁ -C₃ alkyl)amino; Y is H, C₁ -C₄ alkyl, C₁ -C₄ alkoxy, C₁ -C₄ haloalkoxy, C₁ -C₄ haloalkylthio, C₁ -C₄ alkylthio, C₂ -C₅ alkoxyalkyl, C₂ -C₅ alkoxyalkoxy, amino, C₁ -C₃ alkylamino, di(C₁ -C₃ alkyl)amino, C₃ -C₄ alkenyloxy, C₃ -C₄ alkynyloxy, C₂ -C₅ alkyl thioalkyl, C₂ -C₅ alkylsulfinylalkyl, C₂ -C₅ alkylsulfonylalkyl, C₁ -C₄ haloalkyl, C₂ -C₄ alkynyl, C₃ -C₅ cycloalkyl, azido, cyano, ##STR64## or N(OCH₃)CH₃ ; m is 2 or 3; Q₁ and Q₂ are independently O or S; R_(a) is H or C₁ -C₃ alkyl; R_(b) and R_(c) are independently C₁ -C₃ alkyl; and Z⁴ is CH, CCH₃, CC₂ H₅, CCl or CBr;and their agriculturally suitable salts; provided that (1) when X is halogen, then Z⁴ is CH and Y is OCH₃, OC₂ H₅, NH₂, NHCH₃, N(CH₃)₂, OCF₂ H, OCF₂ Br or N(OCH₃)CH₃ ; (2) when X or Y is C₁ haloalkoxy, then Z⁴ is CH; (3) when W is S, then R is H, Z⁴ is CH, and Y is CH₃, OCH₃, OC₂ H₅, CH₂ OCH₃, C₂ H₅, CF₃, SCH₃, OCH₂ CH═CH₂, OCH₂ C.tbd.CH, OCH₂ CH₂ OCH₃, CH(OCH₃)₂ or ##STR65## (4) when the total number of carbon atoms of X and Y is greater than four, then the greatest combined number of carbons of any two substituents on an L, selected from R¹, R², R³, R⁴, R⁵ and R¹⁵ is less than or equal to six; (5) the total of carbon atoms of R¹⁰ and R¹¹ is less than or equal to five.
 2. Compounds of claim 1 wherein L is L-1, L-3, L-4a, L-4b, L-5, L-6, L-7, L-10, L-11, L-14, L-16, L-19 or L-20.
 3. Compounds of claim 2 wherein W is O and Z⁴ is CH.
 4. Compounds of claim 3 whereinX is C₁ -C₂ alkyl, C₁ -C₂ alkoxy, Cl, F, Br, I, OCF₂ H, CH₂ F, CF₃, OCH₂ CH₂ F, OCH₂ CHF₂, OCH₂ CF₃, CH₂ Cl or CH₂ Br; Y is H, C₁ -C₂ alkyl, C₁ -C₂ alkoxy, CH₂ OCH₃, CH₂ OCH₂ CH₃, NHCH₃, N(OCH₃)CH₃, N(CH₃)₂, CF₃, SCH₃, OCH₂ CH═CH₂, OCH₂ C.tbd.CH, OCH₂ CH₂ OCH₃, CH₂ SCH₃, ##STR66## OCF₂ H, OCH₂ Br, SCF₂ H, cyclopropyl, C.tbd.CH or C.tbd.CCH₃ ; and R_(b) and R_(c) are independently CH₃ or CH₂ CH₃.
 5. Compounds of claim 4 whereR¹ is H, halogen, C₁ -C₂ alkyl, C₁ -C₂ haloalkyl, OR⁶, SR⁶, S(O)R⁶, S(O)₂ R⁶, CO₂ R⁷, C(O)NR⁸ R⁹, S(O)₂ NR¹⁰ R¹¹, C₂ -C₃ alkenyl, C₂ -C₃ haloalkenyl, NO₂, CN, C(O)R¹², C(R¹³)═NOR¹⁴ or C₁ -C₂ alkyl substituted by C₁ -C₂ alkoxy, C₁ -C₂ alkylthio or CN; R² is H, CH₃ or OCH₃ ; R⁵ is H, halogen, C₁ -C₂ alkyl, C₁ -C₂ haloalkyl, OR⁶, SR⁶, S(O)R⁶, S(O)₂ R⁶, CO₂ R⁷, C(O)NR⁸ R⁹, S(O)₂ NR¹⁰ R¹¹, C₂ -C₃ alkenyl, C₂ -C₃ haloalkenyl, NO₂, CN, C(O)R¹², or C₁ -C₂ alkyl substituted by C₁ -C₂ alkoxy, C₁ -C₂ alkylthio or CN; R⁶ is C₁ -C₃ alkyl, C₁ -C₃ haloalkyl, C₃ alkenyl, C₂ -C₃ haloalkenyl, propargyl, cyclopropyl or cyclopropylmethyl.
 6. Compounds of claim 5 whereX is CH₃, OCH₃ OCH₂ CH₃, Cl or OCF₂ H; Y is CH₃, OCH₃, C₂ H₅, CH₂ OCH₃, NHCH₃, CH(OCH₃)₃ or cyclopropyl; and R is H.
 7. Compounds of claim 6 where L is L-1.
 8. Compounds of claim 6 where L is L-3.
 9. Compounds of claim 6 where L is L-4a.
 10. Compounds of claim 6 where L is L-4b.
 11. Compounds of claim 6 where L is L-5.
 12. Compounds of claim 6 where L is L-6.
 13. Compounds of claim 6 where L is L-7.
 14. Compounds of claim 6 where L is L-10.
 15. Compounds of claim 6 where L is L-11.
 16. Compounds of claim 6 where L is L-14.
 17. Compounds of claim 6 where L is L-19.
 18. Compounds of claim 6 where L is L-20.
 19. An agriculturally suitable composition for controlling the growth of undesired vegetation comprising an effective amount of a compound of claim 1 and at least one of the following: surfactant, solid diluent or liquid diluent.
 20. An agriculturally suitable composition for controlling the growth of undesired vegetation comprising an effective amount of a compound of claim 2 and at least one of the following: surfactant, solid diluent or liquid diluent.
 21. An agriculturally suitable composition for controlling the growth of undesired vegetation comprising an effective amount of a compound of claim 3 and at least one of the following: surfactant, solid diluent or liquid diluent.
 22. An agriculturally suitable composition for controlling the growth of undesired vegetation comprising an effective amount of a compound of claim 4 and at least one of the following: surfactant, solid diluent or liquid diluent.
 23. An agriculturally suitable composition for controlling the growth of undesired vegetation comprising an effective amount of a compound of claim 5 and at least one of the following: surfactant, solid diluent or liquid diluent.
 24. An agriculturally suitable composition for controlling the growth of undesired vegetation comprising an effective amount of a compound of claim 6 and at least one of the following: surfactant, solid diluent or liquid diluent.
 25. An agriculturally suitable composition for controlling the growth of undesired vegetation comprising an effective amount of a compound of claim 7 and at least one of the following: surfactant, solid diluent or liquid diluent.
 26. An agriculturally suitable composition for controlling the growth of undesired vegetation comprising an effective amount of a compound of claim 8 and at least one of the following: surfactant, solid diluent or liquid diluent.
 27. An agriculturally suitable composition for controlling the growth of undesired vegetation comprising an effective amount of a compound of claim 9 and at least one of the following: surfactant, solid diluent or liquid diluent.
 28. An agriculturally suitable composition for controlling the growth of undesired vegetation comprising an effective amount of a compound of claim 10 and at least one of the following: surfactant, solid diluent or liquid diluent.
 29. A method for controlling the growth of undesired vegetation which comprises applying to the locus to be protected an effective amount of a compound of claim
 1. 30. A method for controlling the growth of undesired vegetation which comprises applying to the locus to be protected an effective amount of a compound of claim
 2. 31. A method for controlling the growth of undesired vegetation which comprises applying to the locus to be protected an effective amount of a compound of claim
 3. 32. A method for controlling the growth of undesired vegetation which comprises applying to the locus to be protected an effective amount of a compound of claim
 4. 33. A method for controlling the growth of undesired vegetation which comprises applying to the locus to be protected an effective amount of a compound of claim
 5. 34. A method for controlling the growth of undesired vegetation which comprises applying to the locus to be protected an effective amount of a compound of claim
 6. 35. A method for controlling the growth of undesired vegetation which comprises applying to the locus to be protected an effective amount of a compound of claim
 7. 36. A method for controlling the growth of undesired vegetation which comprises applying to the locus to be protected an effective amount of a compound of claim
 8. 37. A method for controlling the growth of undesired vegetation which comprises applying to the locus to be protected an effective amount of a compound of claim
 9. 38. A method for controlling the growth of undesired vegetation which comprises applying to the locus to be protected an effective amount of a compound of claim
 10. 